Protein: PRS4
26S proteasome regulatory subunit 4 homolog (Tat-binding homolog 5)

Gene: PRS4, RPT2
Organism: Saccharomyces cerevisiae S288C
Interactions: 137
UniProt ID: P40327

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

771715

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

23

20

Small-scale

0.988

High

703910

PRS7
26S proteasome regulatory subunit 7 homolog

15

20

Small-scale

0.986

High

753835

RPN1
26S proteasome regulatory subunit RPN1

14

20

Small-scale

0.983

High

748945

HSM3
DNA mismatch repair protein HSM3

7

2

Small-scale

0.958

High

703805

PRS6B
26S proteasome regulatory subunit 6B homolog

6

19

Small-scale

0.943

High

771730

PRS8
26S proteasome regulatory subunit 8 homolog

5

19

Small-scale

0.925

High

771716

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

11

High-throughput

0.896

High

771742

RPN7
26S proteasome regulatory subunit RPN7

4

20

Small-scale

0.896

High

703645

PRS6A
26S proteasome regulatory subunit 6A

4

19

High-throughput

0.895

High

697092

RAD23
UV excision repair protein RAD23

4

20

High-throughput

0.881

High

604804

PSB4
Proteasome subunit beta type-4

4

20

Small-scale

0.881

High

771720

PSD10
Probable 26S proteasome regulatory subunit p28

3

8

Small-scale

0.847

High

477313

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

20

High-throughput

0.778

High

771724

PRS10
26S proteasome subunit RPT4

2

19

High-throughput

0.776

High

771745

RPN8
26S proteasome regulatory subunit RPN8

2

20

High-throughput

0.776

High

771709

PSMD9
Probable 26S proteasome regulatory subunit p27

2

11

Small-scale

0.767

High

619477

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.754

High

771750

RPN5
26S proteasome regulatory subunit RPN5

6

20

Small-scale

0.734

High

756944

RPN10
26S proteasome regulatory subunit RPN10

5

17

Small-scale

0.718

High

691478

RPN12
26S proteasome regulatory subunit RPN12

4

7

High-throughput

0.694

High

771751

RPN6
26S proteasome regulatory subunit RPN6

4

20

High-throughput

0.694

High

294130

SEM1
26S proteasome complex subunit SEM1

4

2

Small-scale

0.683

High

771723

RPN14
26S proteasome regulatory subunit RPN14

3

12

High-throughput

0.667

High

771737

RPN9
26S proteasome regulatory subunit RPN9

3

15

High-throughput

0.662

High

753404

ECM29
Proteasome component ECM29

3

7

High-throughput

0.656

High

693312

RPN2
26S proteasome regulatory subunit RPN2

3

20

Small-scale

0.650

High

715343

SPT7
Transcriptional activator SPT7

2

6

Small-scale

0.619

High

578542

SEC18
Vesicular-fusion protein SEC18

1

10

High-throughput

0.618

High

597249

PSA7
Probable proteasome subunit alpha type-7

1

20

High-throughput

0.618

High

597329

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.618

High

619365

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.618

High

619978

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.618

High

625942

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

632492

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

675423

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.618

High

675475

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

680757

HS104
Heat shock protein 104

1

4

High-throughput

0.618

High

689187

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

737172

LONM
Lon protease homolog, mitochondrial

1

19

High-throughput

0.618

High

751167

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

771332

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

771365

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.618

High

771736

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.618

High

771752

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.618

High

141853

RPN13
26S proteasome regulatory subunit RPN13

2

2

High-throughput

0.611

High

766858

RPN3
26S proteasome regulatory subunit RPN3

2

13

High-throughput

0.601

High

628126

SIS1
Protein SIS1

2

7

High-throughput

0.584

High

742828

GBLP
Small ribosomal subunit protein RACK1

2

9

Small-scale

0.584

High

705245

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.575

High

771721

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

High-throughput

0.575

High

771728

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.575

High

543845

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.571

High

607281

RFA1
Replication factor A protein 1

1

5

High-throughput

0.536

High

744630

TAF5
Transcription initiation factor TFIID subunit 5

1

6

High-throughput

0.536

High

757425

SPT8
Transcription factor SPT8

1

2

High-throughput

0.536

High

771733

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

771754

SUS1
Transcription and mRNA export factor SUS1

1

1

High-throughput

0.536

High

771712

SKP2
F-box protein SKP2

1

0

High-throughput

0.513

High

771722

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

771731

ADA2
Transcriptional adapter 2

1

0

High-throughput

0.513

High

381550

GAL4
Regulatory protein GAL4

1

2

Small-scale

0.501

High

752129

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.501

High

771748

PUS9
tRNA pseudouridine(32) synthase, mitochondrial

1

0

High-throughput

0.493

High

141367

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

339672

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.479

High

366381

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

407090

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

407951

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

482292

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

524332

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

566184

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

606663

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.479

High

631915

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

633866

SGF29
SAGA-associated factor 29

1

1

Small-scale

0.479

High

636148

NOT1
General negative regulator of transcription subunit 1

1

1

Small-scale

0.479

High

662388

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

692013

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

700931

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

716256

SPT10
Protein SPT10

1

2

High-throughput

0.479

High

716438

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

729945

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

730818

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.479

High

731550

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.479

High

747930

UMP1
Proteasome maturation factor UMP1

1

1

High-throughput

0.479

High

752488

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

771714

BLM10
Proteasome activator BLM10

1

5

High-throughput

0.479

High

771717

MPS3
Spindle pole body assembly component MPS3

1

2

High-throughput

0.479

High

771718

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.479

High

771719

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

771726

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

8

High-throughput

0.479

High

771727

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

771729

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

771732

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

771734

RPN4
Protein RPN4

1

2

Small-scale

0.479

High

771738

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

771741

POC1
Proteasome chaperone 1

1

1

High-throughput

0.479

High

771743

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

771744

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

771749

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

771753

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

771739

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.460

High

771725

NOG2
Nucleolar GTP-binding protein 2

1

0

Small-scale

0.458

High

412563

CDC7
Cell division control protein 7

1

20

Small-scale

0.445

High

491403

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

494115

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

511528

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

633269

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

760744

TCPG
T-complex protein 1 subunit gamma

1

3

High-throughput

0.445

High

761235

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

768573

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

771711

EMW1
Essential for maintenance of the cell wall protein 1

1

7

High-throughput

0.445

High

358097

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

383182

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

405658

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

413540

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

425987

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

471089

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

472225

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

480137

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

480703

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

561482

NCPR
NADPH--cytochrome P450 reductase

1

4

High-throughput

0.437

High

634632

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.437

High

636229

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

645479

RS7A
Small ribosomal subunit protein eS7A

1

5

High-throughput

0.437

High

700449

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

701460

SC61A
Protein transport protein SEC61

1

2

High-throughput

0.437

High

706307

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

762257

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

771707

MLP2
Protein MLP2

1

5

High-throughput

0.437

High

771710

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.437

High

771713

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

771735

ESC1
Silent chromatin protein ESC1

1

6

High-throughput

0.437

High

771746

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

771740

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.426

High

691810

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.407

High

771708

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

771747

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024