Protein: SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.359) (Lysine N-methyltransferase 3) (SET domain-containing protein 2)

Gene: SET2
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: P46995

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006353 - DNA-templated transcription termination
GO:0006354 - DNA-templated transcription elongation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810349

H3
Histone H3

6

20

Small-scale

0.947

High

356561

H4
Histone H4

4

8

Small-scale

0.878

High

375432

RPB1
DNA-directed RNA polymerase II subunit RPB1

9

10

Small-scale

0.752

High

558130

RPB3
DNA-directed RNA polymerase II subunit RPB3

7

1

Small-scale

0.736

High

440058

RPB2
DNA-directed RNA polymerase II subunit RPB2

6

2

Small-scale

0.721

High

593075

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

1

Small-scale

0.640

High

593157

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

1

Small-scale

0.640

High

655570

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

1

Small-scale

0.640

High

710021

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

1

Small-scale

0.640

High

742870

GBLP
Small ribosomal subunit protein RACK1

1

15

High-throughput

0.618

High

757140

RPB11
DNA-directed RNA polymerase II subunit RPB11

3

0

Small-scale

0.613

High

772995

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

3

0

Small-scale

0.613

High

511816

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.601

High

413589

RS14A
Small ribosomal subunit protein uS11A

2

2

High-throughput

0.595

High

810343

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

High-throughput

0.588

High

650325

SPT5
Transcription elongation factor SPT5

2

6

High-throughput

0.584

High

810355

GCN5
Histone acetyltransferase GCN5

1

20

Small-scale

0.578

High

392487

H2A2
Histone H2A.2

1

14

High-throughput

0.575

High

810329

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

19

High-throughput

0.575

High

810384

H2AZ
Histone H2A.Z

1

13

High-throughput

0.575

High

407151

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.571

High

810377

RS10A
Small ribosomal subunit protein eS10A

2

5

High-throughput

0.571

High

542134

CYC8
General transcriptional corepressor CYC8

1

13

Small-scale

0.561

High

810373

BRE1
E3 ubiquitin-protein ligase BRE1

1

10

Small-scale

0.561

High

593246

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.559

High

593328

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

Small-scale

0.559

High

604697

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.559

High

701338

SPT4
Transcription elongation factor SPT4

2

0

High-throughput

0.559

High

494308

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

810360

RCO1
Transcriptional regulatory protein RCO1

1

20

High-throughput

0.515

High

810381

YRA1
RNA annealing protein YRA1

1

11

High-throughput

0.515

High

342962

ENO2
Enolase 2

1

4

High-throughput

0.501

High

389111

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.501

High

597256

PSA7
Probable proteasome subunit alpha type-7

1

5

High-throughput

0.501

High

613824

TKT1
Transketolase 1

1

3

High-throughput

0.501

High

710310

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.501

High

810332

YJ66
Uncharacterized oxidoreductase YJR096W

1

1

High-throughput

0.501

High

810347

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

11

High-throughput

0.501

High

810357

RUB1
NEDD8-like protein RUB1

1

6

High-throughput

0.501

High

810379

HOSM
Homocitrate synthase, mitochondrial

1

1

High-throughput

0.501

High

565277

SPO12
Sporulation-specific protein 12

1

0

Small-scale

0.486

High

703673

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.481

High

708019

NUF2
Kinetochore protein NUF2

1

3

High-throughput

0.481

High

710781

CASP
Protein CASP

1

12

High-throughput

0.481

High

792434

GZF3
Protein GZF3

1

9

High-throughput

0.481

High

810345

PRS10
26S proteasome subunit RPT4

1

6

High-throughput

0.481

High

810363

RPN7
26S proteasome regulatory subunit RPN7

1

1

High-throughput

0.481

High

810378

NOP53
Ribosome biogenesis protein NOP53

1

2

High-throughput

0.481

High

141788

YL269
Putative uncharacterized protein YLR269C

1

0

High-throughput

0.480

High

345214

IPA3
Protease A inhibitor 3

1

0

High-throughput

0.480

High

501295

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.480

High

507802

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.480

High

645764

INO2
Protein INO2

1

0

Small-scale

0.480

High

696928

FRDS
Fumarate reductase 1

1

0

High-throughput

0.480

High

743949

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

High-throughput

0.480

High

759389

STM1
Suppressor protein STM1

1

0

High-throughput

0.480

High

784491

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.480

High

810018

GON7
EKC/KEOPS complex subunit GON7

1

0

High-throughput

0.480

High

810338

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.480

High

810344

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.480

High

810370

ARR2
Arsenical-resistance protein 2

1

0

High-throughput

0.480

High

141407

RS9A
Small ribosomal subunit protein uS4A

1

5

High-throughput

0.479

High

358140

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

383225

RL25
Large ribosomal subunit protein uL23

1

5

High-throughput

0.479

High

405699

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

407991

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

426026

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

471134

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

472269

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.479

High

480182

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

480751

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

482330

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

539477

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

4

Small-scale

0.479

High

619152

SPT6
Transcription elongation factor SPT6

1

5

High-throughput

0.479

High

631958

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

645525

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

689905

ASF1
Histone chaperone ASF1

1

3

Small-scale

0.479

High

692827

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.479

High

700495

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

706352

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.479

High

729988

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

731922

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.479

High

752534

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

768155

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

1

High-throughput

0.479

High

784869

T2FB
Transcription initiation factor IIF subunit beta

1

1

High-throughput

0.479

High

810348

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.479

High

810351

NAM8
Protein NAM8

1

5

High-throughput

0.479

High

810353

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

810354

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

810359

POB3
FACT complex subunit POB3

1

4

High-throughput

0.479

High

810367

IWS1
Transcription factor SPN1

1

3

High-throughput

0.479

High

810380

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

810382

BBP
Branchpoint-bridging protein

1

4

Small-scale

0.479

High

733855

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.470

High

702679

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

748285

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.460

High

810333

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

810356

VPS72
Vacuolar protein sorting-associated protein 72

1

0

High-throughput

0.460

High

810364

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.460

High

810368

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

810371

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

662619

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

696643

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

732369

MUD2
Splicing factor MUD2

1

0

Small-scale

0.458

High

775764

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

784852

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

810331

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

810336

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

810341

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

810358

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

810372

ASR1
Alcohol-sensitive RING finger protein 1

1

0

High-throughput

0.458

High

810375

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

810376

SGO1
Shugoshin

1

0

High-throughput

0.458

High

420301

CALM
Calmodulin

1

2

High-throughput

0.457

High

634092

YCC1
Putative uncharacterized protein YCL021W

1

1

High-throughput

0.457

High

689361

ARP2
Actin-related protein 2

1

3

High-throughput

0.457

High

810335

YPT11
GTP-binding protein YPT11

1

5

High-throughput

0.457

High

376833

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

6

High-throughput

0.445

High

407549

RS9B
Small ribosomal subunit protein uS4B

1

5

High-throughput

0.445

High

491662

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

550071

CSK21
Casein kinase II subunit alpha

1

14

High-throughput

0.445

High

605079

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.445

High

633340

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

633962

GBP2
Serine/arginine

1

6

High-throughput

0.445

High

640990

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.445

High

667215

RL8B
Large ribosomal subunit protein eL8B

1

4

High-throughput

0.445

High

680823

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

694982

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

696005

HSP79
Heat shock protein homolog SSE2

1

10

High-throughput

0.445

High

744881

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

High-throughput

0.445

High

757299

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.445

High

761258

CAJ1
Protein CAJ1

1

6

High-throughput

0.445

High

768789

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

775619

DJP1
DnaJ-like protein 1

1

6

High-throughput

0.445

High

810337

RL4B
Large ribosomal subunit protein uL4B

1

3

High-throughput

0.445

High

810352

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.445

High

810365

FKBP4
FK506-binding protein 4

1

3

High-throughput

0.445

High

810383

RUVB2
RuvB-like protein 2

1

7

High-throughput

0.445

High

766757

BIM1
Protein BIM1

1

1

High-throughput

0.439

High

809626

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.426

High

399528

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

628994

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.407

High

705356

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.407

High

765967

DPO5
rDNA transcriptional regulator POL5

1

2

High-throughput

0.407

High

766077

HSP7E
Heat shock protein SSC3, mitochondrial

1

9

High-throughput

0.407

High

798009

ERJ5
ER-localized J domain-containing protein 5

1

5

High-throughput

0.407

High

798362

CSK2B
Casein kinase II subunit beta

1

5

High-throughput

0.407

High

810330

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.407

High

810334

HLJ1
Protein HLJ1

1

3

High-throughput

0.407

High

810339

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.407

High

810361

RRP5
rRNA biogenesis protein RRP5

1

10

High-throughput

0.407

High

657027

ACEA
Isocitrate lyase

1

0

High-throughput

0.269

Low

810340

YGV4
Uncharacterized protein YGL204C

1

0

High-throughput

0.261

Low

810346

YNW6
Putative uncharacterized protein YNL226W

1

0

High-throughput

0.261

Low

810350

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.261

Low

810362

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.261

Low

810366

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.261

Low

810369

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.261

Low

810374

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.261

Low

696973

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

728425

YKF0
Uncharacterized protein YKL050C

1

0

High-throughput

0.251

Low

758075

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.251

Low

763676

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

768332

COG3
Conserved oligomeric Golgi complex subunit 3

1

0

High-throughput

0.251

Low

805271

STB2
Protein STB2

1

0

High-throughput

0.251

Low

810342

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

745740

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

810039

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

775044

YIG0
Uncharacterized protein YIL060W

1

0

High-throughput

0.213

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024