Protein: PUF6
Pumilio homology domain family member 6

Gene: PUF6
Organism: Saccharomyces cerevisiae S288C
Interactions: 191
UniProt ID: Q04373

Gene Ontology (top 5):
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0003729 - mRNA binding
GO:0003730 - mRNA 3'-UTR binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

979442

PUF6
Pumilio homology domain family member 6

2

5

High-throughput

0.776

High

754906

SSF1
Ribosome biogenesis protein SSF1

8

2

Small-scale

0.742

High

979480

IF6
Eukaryotic translation initiation factor 6

6

1

Small-scale

0.736

High

754186

CIC1
Proteasome-interacting protein CIC1

6

1

Small-scale

0.724

High

778855

NOP2
25S rRNA

5

2

Small-scale

0.709

High

638848

SPB4
ATP-dependent rRNA helicase SPB4

5

6

High-throughput

0.709

High

766697

NUG1
Nuclear GTP-binding protein NUG1

5

1

Small-scale

0.706

High

973453

NOG1
Nucleolar GTP-binding protein 1

5

1

Small-scale

0.706

High

979468

YTM1
Ribosome biogenesis protein YTM1

5

4

Small-scale

0.706

High

865754

NOP13
Nucleolar protein 13

4

12

Small-scale

0.691

High

744239

MAK5
ATP-dependent RNA helicase MAK5

4

4

Small-scale

0.687

High

976850

HAS1
ATP-dependent RNA helicase HAS1

4

5

High-throughput

0.686

High

979463

BRX1
Ribosome biogenesis protein BRX1

4

6

Small-scale

0.686

High

979477

DBP10
ATP-dependent RNA helicase DBP10

4

9

Small-scale

0.683

High

859504

NSA1
Ribosome biogenesis protein NSA1

5

0

Small-scale

0.678

High

797393

LOC1
60S ribosomal subunit assembly/export protein LOC1

4

0

Small-scale

0.673

High

704417

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

3

1

High-throughput

0.667

High

732100

SHE2
SWI5-dependent HO expression protein 2

4

0

Small-scale

0.664

High

733930

RPF2
Ribosome biogenesis protein RPF2

4

0

High-throughput

0.658

High

742062

NOP4
Nucleolar protein 4

3

8

Small-scale

0.657

High

776507

RLP7
Ribosome biogenesis protein RLP7

3

2

High-throughput

0.656

High

979444

ERB1
Ribosome biogenesis protein ERB1

3

2

Small-scale

0.650

High

979456

NOC4
Nucleolar complex protein 4

3

2

Small-scale

0.650

High

755327

RPF1
Ribosome production factor 1

4

0

Small-scale

0.649

High

356004

H2B2
Histone H2B.2

3

1

High-throughput

0.643

High

764237

NOC2
Nucleolar complex protein 2

3

0

Small-scale

0.613

High

699725

DRS1
ATP-dependent RNA helicase DRS1

2

5

High-throughput

0.611

High

979449

FKBP4
FK506-binding protein 4

2

3

High-throughput

0.611

High

860878

PESC
Pescadillo homolog

3

0

Small-scale

0.606

High

978431

RRP17
Ribosomal RNA-processing protein 17

3

0

Small-scale

0.606

High

829692

RL4B
Large ribosomal subunit protein uL4B

2

1

Small-scale

0.601

High

979445

RRP5
rRNA biogenesis protein RRP5

2

1

Small-scale

0.601

High

979450

JIP5
WD repeat-containing protein JIP5

2

1

High-throughput

0.601

High

535111

RL3
Large ribosomal subunit protein uL3

3

1

Small-scale

0.593

High

485584

SSBP1
Single-stranded nucleic acid-binding protein

2

7

Small-scale

0.588

High

979467

NIP7
60S ribosome subunit biogenesis protein NIP7

2

0

High-throughput

0.585

High

762020

DHH1
ATP-dependent RNA helicase DHH1

2

9

Small-scale

0.584

High

792570

UTP10
U3 small nucleolar RNA-associated protein 10

2

1

High-throughput

0.584

High

866260

NOP15
Ribosome biogenesis protein 15

2

9

Small-scale

0.584

High

979461

RLP24
Ribosome biogenesis protein RLP24

2

1

Small-scale

0.584

High

979470

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.584

High

710920

URB1
Nucleolar pre-ribosomal-associated protein 1

2

0

Small-scale

0.576

High

479175

RL43B
Large ribosomal subunit protein eL43B

2

1

Small-scale

0.575

High

501245

MAK16
Protein MAK16

2

1

Small-scale

0.571

High

594066

MAK11
Protein MAK11

2

3

Small-scale

0.571

High

628439

SIS1
Protein SIS1

2

1

High-throughput

0.571

High

715481

RRP1
Ribosomal RNA-processing protein 1

2

1

Small-scale

0.571

High

731861

EBP2
rRNA-processing protein EBP2

2

1

Small-scale

0.571

High

979479

NOP58
Nucleolar protein 58

2

2

High-throughput

0.571

High

655893

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

High-throughput

0.563

High

805238

TAF1
Transcription initiation factor TFIID subunit 1

2

0

High-throughput

0.563

High

481068

RL23B
Large ribosomal subunit protein uL14B

2

0

Small-scale

0.559

High

748695

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

979455

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

383343

RL25
Large ribosomal subunit protein uL23

2

1

High-throughput

0.558

High

492355

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.552

High

494895

HSP72
Heat shock protein SSA2

2

10

High-throughput

0.552

High

732244

RRP14
Ribosomal RNA-processing protein 14

2

0

Small-scale

0.547

High

756866

RIX1
Pre-rRNA-processing protein RIX1

2

0

Small-scale

0.547

High

766593

NOP16
Nucleolar protein 16

2

0

Small-scale

0.547

High

768044

NSA2
Ribosome biogenesis protein NSA2

2

0

Small-scale

0.547

High

550114

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.536

High

641058

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

744689

TAF5
Transcription initiation factor TFIID subunit 5

1

2

High-throughput

0.536

High

765983

DPO5
rDNA transcriptional regulator POL5

1

1

High-throughput

0.536

High

864604

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

872756

RL15B
Large ribosomal subunit protein eL15B

1

1

High-throughput

0.536

High

965035

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

975960

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

979451

DBP9
ATP-dependent RNA helicase DBP9

1

8

High-throughput

0.536

High

979476

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.536

High

549488

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.515

High

420582

SPT2
Protein SPT2

1

0

High-throughput

0.513

High

566226

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.513

High

865463

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

979458

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

979459

RIX7
Ribosome biogenesis ATPase RIX7

1

0

High-throughput

0.513

High

979462

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

979481

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

584792

CSK22
Casein kinase II subunit alpha'

1

6

Small-scale

0.501

High

759445

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

667275

RL8B
Large ribosomal subunit protein eL8B

1

2

High-throughput

0.489

High

747624

SHE3
SWI5-dependent HO expression protein 3

1

0

Small-scale

0.479

High

355629

H2B1
Histone H2B.1

1

1

High-throughput

0.479

High

382799

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

392561

H2A2
Histone H2A.2

1

1

High-throughput

0.479

High

403020

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

6

Small-scale

0.479

High

413700

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

471443

RL11A
Large ribosomal subunit protein uL5A

1

2

High-throughput

0.479

High

480304

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

524444

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

544378

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

634446

SPB1
27S pre-rRNA

1

1

High-throughput

0.479

High

634759

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

645129

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

650383

SPT5
Transcription elongation factor SPT5

1

1

High-throughput

0.479

High

663246

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

703112

MRT4
Ribosome assembly factor MRT4

1

3

High-throughput

0.479

High

742984

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

752660

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

757339

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

864680

NOG2
Nucleolar GTP-binding protein 2

1

1

Small-scale

0.479

High

865309

GIS2
Zinc finger protein GIS2

1

3

High-throughput

0.479

High

866454

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

866859

RCM1
25S rRNA

1

2

High-throughput

0.479

High

902051

H3
Histone H3

1

6

High-throughput

0.479

High

965486

NOP3
Serine/arginine

1

12

Small-scale

0.479

High

972629

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

979105

RRB1
Ribosome assembly protein RRB1

1

2

High-throughput

0.479

High

979448

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

979460

NOC3
Nucleolar complex-associated protein 3

1

1

High-throughput

0.479

High

979464

SGO1
Shugoshin

1

1

High-throughput

0.479

High

979466

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.479

High

979473

YRA1
RNA annealing protein YRA1

1

7

High-throughput

0.479

High

979475

RIO1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.479

High

979478

NOP56
Nucleolar protein 56

1

2

Small-scale

0.479

High

141516

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

407308

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

408117

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

420165

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.458

High

558246

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

630252

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

632083

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

635155

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

645639

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

687998

IMB3
Importin subunit beta-3

1

0

Small-scale

0.458

High

688415

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

698933

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

746265

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

747687

BMT2
25S rRNA

1

0

High-throughput

0.458

High

775253

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

860370

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

977764

ARX1
Probable metalloprotease ARX1

1

0

Small-scale

0.458

High

979012

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.458

High

979443

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.458

High

979452

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

979453

ESF1
Pre-rRNA-processing protein ESF1

1

0

Small-scale

0.458

High

979471

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

356703

H4
Histone H4

1

1

High-throughput

0.445

High

366855

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.445

High

478501

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

512635

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

633551

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

680982

HS104
Heat shock protein 104

1

3

High-throughput

0.445

High

692615

ZUO1
Zuotin

1

3

High-throughput

0.445

High

695471

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

705621

HSP78
Heat shock protein 78, mitochondrial

1

4

High-throughput

0.445

High

707930

GCN1
eIF-2-alpha kinase activator GCN1

1

2

High-throughput

0.445

High

761301

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

769404

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

865493

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

960004

SEN1
Helicase SEN1

1

4

Small-scale

0.445

High

979472

SSF2
Ribosome biogenesis protein SSF2

1

2

Small-scale

0.445

High

979474

MAK21
Ribosome biogenesis protein MAK21

1

2

Small-scale

0.445

High

866145

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

405821

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

471830

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.437

High

472385

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

472531

RL31B
Large ribosomal subunit protein eL31B

1

2

Small-scale

0.437

High

478982

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

480872

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

481228

RL1A
Large ribosomal subunit protein uL1A

1

4

High-throughput

0.437

High

481420

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.437

High

564370

RL8A
Large ribosomal subunit protein eL8A

1

2

Small-scale

0.437

High

700615

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

706480

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

762534

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

979457

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

554735

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

588219

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.426

High

979446

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.426

High

368383

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.407

High

399627

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

424703

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.407

High

766195

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.407

High

979447

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

14

High-throughput

0.407

High

763902

IF2P
Eukaryotic translation initiation factor 5B

3

0

Small-scale

0.353

High

357563

RLA4
Large ribosomal subunit protein P2B

1

0

High-throughput

0.279

Low

358252

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

426139

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

471244

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

482451

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

730106

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

820161

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

859320

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low

967747

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

977468

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low

979454

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.249

Low

979465

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

979469

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024