Protein: CDC53
Cell division control protein 53 (Cullin-A) (E3 ubiquitin ligase complex SCF subunit CDC53)

Gene: CDC53
Organism: Saccharomyces cerevisiae S288C
Interactions: 133
UniProt ID: Q12018

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000409 - regulation of transcription by galactose
GO:0000781 - chromosome, telomeric region
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853191

SKP1
Suppressor of kinetochore protein 1

28

20

Small-scale

0.993

High

994548

RBX1
RING-box protein HRT1

15

20

Small-scale

0.986

High

431154

CDC4
Cell division control protein 4

14

20

Small-scale

0.984

High

539493

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

13

20

Small-scale

0.983

High

624323

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

12

19

Small-scale

0.980

High

759337

MET30
F-box protein MET30

10

20

Small-scale

0.978

High

1014849

DCN1
Defective in cullin neddylation protein 1

5

20

Small-scale

0.946

High

810423

DAS1
F-box protein DAS1

5

1

Small-scale

0.927

High

979764

UFO1
Ubiquitin ligase complex F-box protein UFO1

9

0

Small-scale

0.923

High

977843

RUB1
NEDD8-like protein RUB1

4

20

Small-scale

0.860

High

985282

MDM30
Mitochondrial distribution and morphology protein 30

3

0

Small-scale

0.800

High

749024

SAF1
SCF-associated factor 1

5

1

Small-scale

0.720

High

988526

YD306
F-box protein YDR306C

4

1

Small-scale

0.686

High

1014847

HRT3
F-box protein HRT3

4

2

Small-scale

0.686

High

995906

DIA2
Protein DIA2

5

0

Small-scale

0.681

High

987496

YL352
F-box protein YLR352W

4

0

Small-scale

0.664

High

854626

UBC12
NEDD8-conjugating enzyme UBC12

1

20

Small-scale

0.647

High

751500

SIC1
Protein SIC1

2

0

Small-scale

0.619

High

1014851

CSN5
COP9 signalosome complex subunit 5

1

14

Small-scale

0.618

High

791225

SKP2
F-box protein SKP2

1

0

Small-scale

0.614

High

593414

CG12
G1/S-specific cyclin CLN2

2

10

Small-scale

0.601

High

988677

UBX5
UBX domain-containing protein 5

2

5

Small-scale

0.601

High

412598

CDC7
Cell division control protein 7

2

19

Small-scale

0.595

High

977832

YD131
F-box protein YDR131C

2

1

Small-scale

0.595

High

544559

HSC82
ATP-dependent molecular chaperone HSC82

2

19

High-throughput

0.594

High

450227

HSP73
Heat shock protein SSA3

2

14

High-throughput

0.584

High

482500

RS18A
Small ribosomal subunit protein uS13A

2

5

High-throughput

0.584

High

636771

CDC48
Cell division control protein 48

2

12

Small-scale

0.584

High

747774

AMN1
Antagonist of mitotic exit network protein 1

2

20

Small-scale

0.584

High

976278

SLD5
DNA replication complex GINS protein SLD5

2

0

Small-scale

0.569

High

765181

PAC2
Protein PAC2

1

9

Small-scale

0.561

High

1014848

CSN10
COP9 signalosome complex subunit 10

2

0

Small-scale

0.559

High

448524

PRTB
Cerevisin

2

2

High-throughput

0.549

High

1014850

ERG27
3-keto-steroid reductase ERG27

2

1

Small-scale

0.543

High

389999

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.536

High

560464

PDC5
Pyruvate decarboxylase isozyme 2

1

3

High-throughput

0.536

High

640763

PDC6
Pyruvate decarboxylase isozyme 3

1

3

High-throughput

0.536

High

710582

UBX1
UBX domain-containing protein 1

1

9

Small-scale

0.536

High

715408

SPT7
Transcriptional activator SPT7

1

17

High-throughput

0.536

High

975988

GCN5
Histone acetyltransferase GCN5

1

16

High-throughput

0.536

High

715601

PP2C1
Protein phosphatase 2C homolog 1

1

0

High-throughput

0.513

High

367047

HSP82
ATP-dependent molecular chaperone HSP82

1

19

High-throughput

0.500

High

411106

PDC1
Pyruvate decarboxylase isozyme 1

1

3

High-throughput

0.500

High

485855

IF4A
ATP-dependent RNA helicase eIF4A

1

20

High-throughput

0.500

High

516988

INO1
Inositol-3-phosphate synthase

1

2

High-throughput

0.500

High

556355

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.500

High

588254

HSP60
Heat shock protein 60, mitochondrial

1

10

High-throughput

0.500

High

665099

BMH1
Protein BMH1

1

3

High-throughput

0.500

High

995648

SGT1
Protein SGT1

1

0

Small-scale

0.493

High

997090

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

3

High-throughput

0.489

High

985454

UCC1
F-box protein UCC1

1

0

Small-scale

0.480

High

404382

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

141565

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

356777

H4
Histone H4

1

6

High-throughput

0.479

High

407378

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

526793

CG13
G1/S-specific cyclin CLN3

1

6

Small-scale

0.479

High

558307

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

593372

CG11
G1/S-specific cyclin CLN1

1

13

Small-scale

0.479

High

624752

CG23
G2/mitotic-specific cyclin-3

1

3

Small-scale

0.479

High

628562

SIS1
Protein SIS1

1

7

High-throughput

0.479

High

681063

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

730160

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

730936

CENPA
Histone H3-like centromeric protein CSE4

1

6

Small-scale

0.479

High

743044

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.479

High

751149

RCK2
Serine/threonine-protein kinase RCK2

1

12

High-throughput

0.479

High

752716

RS20
Small ribosomal subunit protein uS10

1

6

High-throughput

0.479

High

753974

RPN1
26S proteasome regulatory subunit RPN1

1

5

Small-scale

0.479

High

757038

RPN10
26S proteasome regulatory subunit RPN10

1

2

Small-scale

0.479

High

758718

TEM1
Protein TEM1

1

6

Small-scale

0.479

High

858711

UFD1
Ubiquitin fusion degradation protein 1

1

1

High-throughput

0.479

High

866002

ADE
Adenine deaminase

1

2

High-throughput

0.479

High

902124

H3
Histone H3

1

6

High-throughput

0.479

High

961509

CDC14
Tyrosine-protein phosphatase CDC14

1

5

Small-scale

0.479

High

968094

PRS8
26S proteasome regulatory subunit 8 homolog

1

7

Small-scale

0.479

High

979766

METX
Putative cystathionine gamma-synthase YML082W

1

1

High-throughput

0.479

High

1014844

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

1014846

RPN5
26S proteasome regulatory subunit RPN5

1

20

High-throughput

0.479

High

1014852

CMR1
DNA damage-binding protein CMR1

1

20

High-throughput

0.479

High

663588

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

688476

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

768199

DDI1
DNA damage-inducible protein 1

1

0

Small-scale

0.458

High

978354

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

991332

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1014843

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1014845

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

762732

RCY1
Recyclin-1

1

1

Small-scale

0.457

High

334996

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

6

High-throughput

0.457

High

423924

ATPA
ATP synthase subunit alpha, mitochondrial

1

6

High-throughput

0.457

High

521071

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

576025

ADT2
ADP,ATP carrier protein 2

1

12

High-throughput

0.457

High

687505

EF2
Elongation factor 2

1

8

High-throughput

0.457

High

994430

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

3

High-throughput

0.457

High

341111

CBPY
Carboxypeptidase Y

1

1

High-throughput

0.445

High

492731

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

513076

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.445

High

713031

BMH2
Protein BMH2

1

3

High-throughput

0.445

High

745412

SEA4
SEH-associated protein 4

1

1

High-throughput

0.445

High

748737

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.445

High

753090

OSH3
Oxysterol-binding protein homolog 3

1

3

High-throughput

0.445

High

763255

PRP39
Pre-mRNA-processing factor 39

1

12

High-throughput

0.445

High

766266

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.445

High

769720

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

974043

GDE1
Glycerophosphocholine phosphodiesterase GDE1

1

11

High-throughput

0.445

High

993242

CDC45
Cell division control protein 45

1

1

High-throughput

0.445

High

383396

RL25
Large ribosomal subunit protein uL23

1

6

High-throughput

0.437

High

413754

RS14A
Small ribosomal subunit protein uS11A

1

9

High-throughput

0.437

High

471302

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.437

High

480367

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

645699

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

745926

NU170
Nucleoporin NUP170

1

3

High-throughput

0.437

High

959891

NUM1
Nuclear migration protein NUM1

1

20

High-throughput

0.437

High

996338

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

478686

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.426

High

755966

NDT80
Meiosis-specific transcription factor NDT80

1

0

High-throughput

0.426

High

768322

YEY6
MYG1 protein YER156C

1

0

High-throughput

0.426

High

829098

CTR1
Copper transport protein CTR1

1

0

High-throughput

0.426

High

962613

STP1
Transcription factor STP1

1

0

High-throughput

0.426

High

978161

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.426

High

342395

CISY1
Citrate synthase, mitochondrial

1

3

High-throughput

0.407

High

541815

SEC63
Protein translocation protein SEC63

1

11

High-throughput

0.407

High

607867

SYMM
Methionine--tRNA ligase, mitochondrial

1

6

High-throughput

0.407

High

675027

ITR1
Myo-inositol transporter 1

1

1

High-throughput

0.407

High

812618

IML1
Vacuolar membrane-associated protein IML1

1

5

High-throughput

0.407

High

991496

ATG20
Autophagy-related protein 20

1

3

High-throughput

0.407

High

1014853

LAG2
Cullin-associated NEDD8-dissociated protein 1 homolog

3

0

Small-scale

0.363

High

858811

ZIP2
Protein ZIP2

2

0

Small-scale

0.310

High

986196

BOP2
Protein BOP2

2

0

High-throughput

0.310

High

716138

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

Small-scale

0.261

Low

500632

TIR1
Cold shock-induced protein TIR1

1

0

Small-scale

0.249

Low

762642

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

953551

YD274
Uncharacterized protein YDR274C

1

0

High-throughput

0.238

Low

691163

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.232

Low

744768

KTR4
Probable mannosyltransferase KTR4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024