Protein: CLOCK
Circadian locomoter output cycles protein kaput (mCLOCK) (EC 2.3.1.48)

Gene: CLOCK
Organism: Mus musculus
Interactions: 27
UniProt ID: O08785

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

148289

BMAL1
Basic helix-loop-helix ARNT-like protein 1

22

20

Small-scale

0.989

High

148267

PER2
Period circadian protein homolog 2

8

19

Small-scale

0.960

High

148266

PER1
Period circadian protein homolog 1

3

19

Small-scale

0.827

High

148274

CRY1
Cryptochrome-1

9

16

Small-scale

0.749

High

148283

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

10

Small-scale

0.649

High

148288

CRY2
Cryptochrome-2

3

16

Small-scale

0.636

High

148268

PER3
Period circadian protein homolog 3

1

20

Small-scale

0.618

High

148275

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

20

Small-scale

0.590

High

148285

BHE41
Class E basic helix-loop-helix protein 41

1

5

High-throughput

0.590

High

107038

F8VPR5
histone acetyltransferase

2

20

Small-scale

0.584

High

148270

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.536

High

148271

KMT2A
Histone-lysine N-methyltransferase 2A

1

8

Small-scale

0.536

High

148287

KC1E
Casein kinase I isoform epsilon

1

13

High-throughput

0.506

High

148272

H4
Histone H4

1

6

Small-scale

0.501

High

67205

WDR76
WD repeat-containing protein 76

1

8

Small-scale

0.500

High

148276

DDB1
DNA damage-binding protein 1

1

7

Small-scale

0.500

High

148277

EZH2
Histone-lysine N-methyltransferase EZH2

1

10

Small-scale

0.479

High

148278

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

3

High-throughput

0.479

High

148279

NUP98
Nuclear pore complex protein Nup98-Nup96

1

1

Small-scale

0.479

High

148280

RAE1L
mRNA export factor

1

5

Small-scale

0.479

High

148281

KAT5
Histone acetyltransferase KAT5

1

3

Small-scale

0.479

High

148286

KAT2B
Histone acetyltransferase KAT2B

1

20

Small-scale

0.479

High

148282

CIPC
CLOCK-interacting pacemaker

1

4

High-throughput

0.457

High

59119

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

Small-scale

0.445

High

148269

PARP1
Poly [ADP-ribose] polymerase 1

1

7

Small-scale

0.445

High

148273

KPCG
Protein kinase C gamma type

1

6

Small-scale

0.445

High

148284

Q99JJ1
Cry2 protein

1

16

Small-scale

0.417

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025