Protein: IF6
Eukaryotic translation initiation factor 6 (eIF-6)

Gene: IF6, TIF6
Organism: Saccharomyces cerevisiae S288C
Interactions: 189
UniProt ID: Q12522

Gene Ontology (top 5):
GO:0000054 - ribosomal subunit export from nucleus
GO:0000460 - maturation of 5.8S rRNA
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 - maturation of LSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

973496

NOG1
Nucleolar GTP-binding protein 1

7

2

Small-scale

0.960

High

992634

RLP24
Ribosome biogenesis protein RLP24

5

2

Small-scale

0.902

High

1015711

IF6
Eukaryotic translation initiation factor 6

3

0

Small-scale

0.791

High

535168

RL3
Large ribosomal subunit protein uL3

2

2

Small-scale

0.789

High

481092

RL23B
Large ribosomal subunit protein uL14B

3

0

Small-scale

0.784

High

859651

LSG1
Large subunit GTPase 1

13

5

Small-scale

0.761

High

977788

ARX1
Probable metalloprotease ARX1

15

1

Small-scale

0.760

High

754942

SSF1
Ribosome biogenesis protein SSF1

11

1

Small-scale

0.754

High

864711

NOG2
Nucleolar GTP-binding protein 2

10

5

Small-scale

0.752

High

703146

MRT4
Ribosome assembly factor MRT4

7

2

Small-scale

0.743

High

368536

EF1A
Elongation factor 1-alpha

2

1

Small-scale

0.737

High

979480

PUF6
Pumilio homology domain family member 6

6

1

Small-scale

0.736

High

859535

NSA1
Ribosome biogenesis protein NSA1

6

1

Small-scale

0.733

High

756406

NMD3
60S ribosomal export protein NMD3

6

1

Small-scale

0.727

High

860918

PESC
Pescadillo homolog

12

0

Small-scale

0.726

High

756893

RIX1
Pre-rRNA-processing protein RIX1

9

0

Small-scale

0.721

High

980185

ERB1
Ribosome biogenesis protein ERB1

5

1

Small-scale

0.718

High

976897

HAS1
ATP-dependent RNA helicase HAS1

5

4

Small-scale

0.714

High

733992

RPF2
Ribosome biogenesis protein RPF2

7

0

Small-scale

0.710

High

768073

NSA2
Ribosome biogenesis protein NSA2

6

0

Small-scale

0.699

High

797424

LOC1
60S ribosomal subunit assembly/export protein LOC1

6

0

Small-scale

0.699

High

994476

BRX1
Ribosome biogenesis protein BRX1

4

5

Small-scale

0.696

High

699753

DRS1
ATP-dependent RNA helicase DRS1

4

2

Small-scale

0.694

High

776556

RLP7
Ribosome biogenesis protein RLP7

4

2

Small-scale

0.694

High

992556

NOC3
Nucleolar complex-associated protein 3

4

1

Small-scale

0.694

High

1014875

YTM1
Ribosome biogenesis protein YTM1

4

2

Small-scale

0.694

High

1015557

DBP10
ATP-dependent RNA helicase DBP10

4

1

Small-scale

0.694

High

778899

NOP2
25S rRNA

4

1

Small-scale

0.691

High

594089

MAK11
Protein MAK11

4

1

Small-scale

0.686

High

766736

NUG1
Nuclear GTP-binding protein NUG1

4

5

Small-scale

0.686

High

755355

RPF1
Ribosome production factor 1

5

0

Small-scale

0.684

High

564399

RL8A
Large ribosomal subunit protein eL8A

4

1

Small-scale

0.676

High

861421

SDA1
Protein SDA1

3

1

High-throughput

0.667

High

865693

IPI3
Pre-rRNA-processing protein IPI3

3

2

High-throughput

0.667

High

866294

NOP15
Ribosome biogenesis protein 15

4

0

High-throughput

0.664

High

993179

BUD20
Bud site selection protein 20

4

0

Small-scale

0.664

High

970204

PVH1
Tyrosine-protein phosphatase YVH1

3

1

Small-scale

0.658

High

764279

NOC2
Nucleolar complex protein 2

4

0

Small-scale

0.657

High

604646

RPA2
DNA-directed RNA polymerase I subunit RPA135

3

1

High-throughput

0.650

High

630900

NLE1
Ribosome assembly protein 4

4

0

Small-scale

0.648

High

638908

SPB4
ATP-dependent rRNA helicase SPB4

3

3

High-throughput

0.640

High

715512

RRP1
Ribosomal RNA-processing protein 1

3

1

Small-scale

0.640

High

641112

RL5
Large ribosomal subunit protein uL18

3

0

Small-scale

0.638

High

754229

CIC1
Proteasome-interacting protein CIC1

3

0

Small-scale

0.628

High

766615

NOP16
Nucleolar protein 16

3

0

Small-scale

0.628

High

513333

SSB1
Ribosome-associated molecular chaperone SSB1

3

1

Small-scale

0.624

High

382821

RL24A
Large ribosomal subunit protein eL24A

1

2

Small-scale

0.618

High

667310

RL8B
Large ribosomal subunit protein eL8B

2

1

Small-scale

0.611

High

549539

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.602

High

704923

LHP1
La protein homolog

2

0

High-throughput

0.602

High

410200

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

1

High-throughput

0.601

High

691607

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

1

High-throughput

0.601

High

741495

CCL1
Cyclin CCL1

2

1

High-throughput

0.601

High

747058

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

2

High-throughput

0.601

High

406430

RL15A
Large ribosomal subunit protein eL15A

2

0

High-throughput

0.585

High

645166

RL16A
Large ribosomal subunit protein uL13A

2

0

High-throughput

0.585

High

634472

SPB1
27S pre-rRNA

2

1

Small-scale

0.584

High

748907

REI1
Cytoplasmic 60S subunit biogenesis factor REI1

2

2

Small-scale

0.584

High

988752

REH1
Cytoplasmic 60S subunit biogenesis factor REH1

2

2

Small-scale

0.584

High

1014986

NOP53
Ribosome biogenesis protein NOP53

2

1

High-throughput

0.584

High

367140

HSP82
ATP-dependent molecular chaperone HSP82

2

2

Small-scale

0.571

High

492946

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.571

High

495393

HSP72
Heat shock protein SSA2

2

1

Small-scale

0.571

High

769887

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

Small-scale

0.571

High

765116

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

0

Small-scale

0.559

High

810605

ALB1
Ribosome biogenesis protein ALB1

2

0

Small-scale

0.559

High

978452

RRP17
Ribosomal RNA-processing protein 17

2

0

High-throughput

0.559

High

987659

RRP15
Ribosomal RNA-processing protein 15

2

0

Small-scale

0.559

High

715631

SQT1
Ribosome assembly protein SQT1

1

1

High-throughput

0.541

High

479196

RL43B
Large ribosomal subunit protein eL43B

1

0

Small-scale

0.537

High

399679

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

404746

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.536

High

550157

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.536

High

696432

PP12
Serine/threonine-protein phosphatase PP1-2

1

2

High-throughput

0.536

High

829730

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.536

High

865785

NOP13
Nucleolar protein 13

1

2

High-throughput

0.536

High

866881

HDA1
Histone deacetylase HDA1

1

3

High-throughput

0.536

High

965082

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

982928

RRP5
rRNA biogenesis protein RRP5

1

2

High-throughput

0.536

High

996036

ULS1
ATP-dependent helicase ULS1

1

1

High-throughput

0.536

High

1015317

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.536

High

404929

RL9A
Large ribosomal subunit protein uL6A

1

0

High-throughput

0.513

High

419415

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

676500

XPO1
Exportin-1

1

0

High-throughput

0.513

High

770478

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.513

High

811679

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.513

High

961967

AP1M1
AP-1 complex subunit mu-1-I

1

0

High-throughput

0.513

High

977548

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.513

High

982962

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.513

High

991551

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

995485

DNLI4
DNA ligase 4

1

0

High-throughput

0.513

High

995913

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

996278

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.513

High

664574

HRR25
Casein kinase I homolog HRR25

1

0

Small-scale

0.480

High

376988

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

Small-scale

0.479

High

472467

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

472537

RL31B
Large ribosomal subunit protein eL31B

1

1

Small-scale

0.479

High

480393

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

481448

RL2A
Large ribosomal subunit protein uL2A

1

1

High-throughput

0.479

High

544653

HSC82
ATP-dependent molecular chaperone HSC82

1

2

Small-scale

0.479

High

588280

HSP60
Heat shock protein 60, mitochondrial

1

2

Small-scale

0.479

High

695883

HSP7F
Heat shock protein homolog SSE1

1

3

Small-scale

0.479

High

731898

EBP2
rRNA-processing protein EBP2

1

1

High-throughput

0.479

High

743075

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

757381

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

3

High-throughput

0.479

High

767095

ARB1
ABC transporter ATP-binding protein ARB1

1

1

Small-scale

0.479

High

772364

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.479

High

975880

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

978063

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

979093

DHR1
Probable ATP-dependent RNA helicase DHR1

1

2

High-throughput

0.479

High

979125

RRB1
Ribosome assembly protein RRB1

1

2

High-throughput

0.479

High

986496

FKBP4
FK506-binding protein 4

1

3

High-throughput

0.479

High

986593

JIP5
WD repeat-containing protein JIP5

1

1

High-throughput

0.479

High

986633

DBP9
ATP-dependent RNA helicase DBP9

1

2

High-throughput

0.479

High

987705

NOC4
Nucleolar complex protein 4

1

3

High-throughput

0.479

High

1015249

MAK21
Ribosome biogenesis protein MAK21

1

3

Small-scale

0.479

High

1015712

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

141596

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

358329

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

383425

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

405900

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

407414

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

408199

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

408503

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

413785

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

426222

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

471329

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

480960

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

481719

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.458

High

482528

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

482807

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

501273

MAK16
Protein MAK16

1

0

High-throughput

0.458

High

628626

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

632165

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

634840

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

645727

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

663764

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

665126

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

681112

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

688504

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

698193

AFG2
ATPase family gene 2 protein

1

0

High-throughput

0.458

High

700703

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

704461

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

706570

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

730189

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

732267

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

746283

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

748754

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.458

High

752744

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

755268

IPI1
Pre-rRNA-processing protein IPI1

1

0

High-throughput

0.458

High

762697

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

763597

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.458

High

775300

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

775915

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

784253

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.458

High

792643

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

820251

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

859973

VIR
Protein virilizer

1

0

High-throughput

0.458

High

865335

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

866586

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

872837

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

902162

H3
Histone H3

1

0

High-throughput

0.458

High

967841

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

986299

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

991381

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

995852

SGO1
Shugoshin

1

0

High-throughput

0.458

High

996213

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

996365

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

996387

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.458

High

997040

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.458

High

1014837

YO289
Uncharacterized protein YOR289W

1

0

Small-scale

0.458

High

1014864

MDN1
Midasin

1

0

High-throughput

0.458

High

1015680

NOP58
Nucleolar protein 58

1

0

High-throughput

0.458

High

499128

RL4A
Large ribosomal subunit protein uL4A

1

4

High-throughput

0.445

High

744721

TAF5
Transcription initiation factor TFIID subunit 5

1

3

High-throughput

0.445

High

865517

JJJ1
J protein JJJ1

1

2

High-throughput

0.445

High

979281

VMS1
tRNA endonuclease VMS1

1

3

Small-scale

0.445

High

752091

KPR3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.426

High

859992

CGR1
rRNA-processing protein CGR1

1

0

High-throughput

0.426

High

864645

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.426

High

970426

ADA2
Transcriptional adapter 2

1

0

High-throughput

0.426

High

415853

HIS7
Imidazoleglycerol-phosphate dehydratase

1

0

High-throughput

0.279

Low

1015704

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.279

Low

711025

MTC2
Maintenance of telomere capping protein 2

1

0

High-throughput

0.261

Low

692986

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

745962

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

866823

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

1015713

YO192
Uncharacterized protein YOR192C-C

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024