Protein: MED2
Mediator of RNA polymerase II transcription subunit 2 (Mediator complex subunit 2)

Gene: MED2
Organism: Saccharomyces cerevisiae S288C
Interactions: 65
UniProt ID: Q12124

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693945

MED18
Mediator of RNA polymerase II transcription subunit 18

13

0

Small-scale

0.724

High

772527

MED3
Mediator of RNA polymerase II transcription subunit 3

9

0

Small-scale

0.716

High

693571

MED17
Mediator of RNA polymerase II transcription subunit 17

9

0

Small-scale

0.715

High

994565

MED7
Mediator of RNA polymerase II transcription subunit 7

8

0

Small-scale

0.713

High

586343

MED15
Mediator of RNA polymerase II transcription subunit 15

8

0

Small-scale

0.711

High

581386

MED14
Mediator of RNA polymerase II transcription subunit 14

7

0

Small-scale

0.706

High

748119

MED8
Mediator of RNA polymerase II transcription subunit 8

7

0

Small-scale

0.704

High

704164

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.691

High

1015071

MED4
Mediator of RNA polymerase II transcription subunit 4

6

0

Small-scale

0.691

High

710280

MED20
Mediator of RNA polymerase II transcription subunit 20

5

0

Small-scale

0.676

High

859244

MED5
Mediator of RNA polymerase II transcription subunit 5

5

0

Small-scale

0.676

High

760601

SSN3
Meiotic mRNA stability protein kinase SSN3

4

0

Small-scale

0.658

High

686871

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

High-throughput

0.654

High

986570

MED10
Mediator of RNA polymerase II transcription subunit 10

4

0

High-throughput

0.654

High

1015070

MED1
Mediator of RNA polymerase II transcription subunit 1

4

0

High-throughput

0.654

High

693611

MED22
Mediator of RNA polymerase II transcription subunit 22

4

0

Small-scale

0.644

High

751480

MED31
Mediator of RNA polymerase II transcription subunit 31

3

0

Small-scale

0.622

High

636003

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

High-throughput

0.616

High

754288

MED6
Mediator of RNA polymerase II transcription subunit 6

3

0

High-throughput

0.616

High

758031

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

High-throughput

0.616

High

1015073

MED11
Mediator of RNA polymerase II transcription subunit 11

3

0

High-throughput

0.616

High

696098

HSP79
Heat shock protein homolog SSE2

2

1

High-throughput

0.588

High

626045

MED19
Mediator of RNA polymerase II transcription subunit 19

2

0

High-throughput

0.576

High

814171

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

High-throughput

0.576

High

587893

AP1
AP-1-like transcription factor YAP1

2

0

High-throughput

0.563

High

972932

IMA1
Importin subunit alpha

2

0

High-throughput

0.563

High

558318

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.559

High

988048

ARR1
Arsenical-resistance protein ARR1

1

0

Small-scale

0.529

High

492776

HSP71
Heat shock protein SSA1

2

0

High-throughput

0.528

High

513132

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.528

High

542158

CYC8
General transcriptional corepressor CYC8

1

0

Small-scale

0.513

High

676460

XPO1
Exportin-1

1

0

High-throughput

0.513

High

381629

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

607356

RFA1
Replication factor A protein 1

1

0

Small-scale

0.460

High

368761

GCN4
General control transcription factor GCN4

1

0

Small-scale

0.458

High

375536

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

544579

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

561923

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.458

High

715753

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

728338

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

814157

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

1015072

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

499114

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

829722

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.445

High

756889

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.438

High

1015069

SAS10
Something about silencing protein 10

1

0

High-throughput

0.438

High

368497

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

382816

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.426

High

404734

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.426

High

413761

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.426

High

534860

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.426

High

535157

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

667303

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.426

High

732805

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.426

High

784248

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.426

High

810304

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.426

High

978041

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.426

High

747052

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

0

High-throughput

0.307

High

768353

COG3
Conserved oligomeric Golgi complex subunit 3

2

0

High-throughput

0.307

High

141762

THP2
THO complex subunit THP2

1

0

High-throughput

0.265

Low

423976

CBP1
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

810474

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

340311

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

556367

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

837381

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024