Protein: EST1
Telomere elongation protein EST1 (Ever shorter telomeres protein 1)

Gene: EST1
Organism: Saccharomyces cerevisiae S288C
Interactions: 148
UniProt ID: P17214

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0003697 - single-stranded DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

566149

CDC13
Cell division control protein 13

7

0

Small-scale

0.716

High

566233

TERT
Telomerase reverse transcriptase

7

0

Small-scale

0.712

High

566227

KU80
ATP-dependent DNA helicase II subunit 2

3

1

Small-scale

0.640

High

566220

EST3
Telomere replication protein EST3

3

0

Small-scale

0.619

High

566197

MPS3
Spindle pole body assembly component MPS3

2

0

Small-scale

0.587

High

566120

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.586

High

566166

RPF2
Ribosome biogenesis protein RPF2

2

0

High-throughput

0.585

High

365745

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.571

High

566138

MAS5
Mitochondrial protein import protein MAS5

2

0

High-throughput

0.569

High

566206

POP6
Ribonucleases P/MRP protein subunit POP6

2

0

Small-scale

0.559

High

566245

RUXE
Small nuclear ribonucleoprotein E

2

0

Small-scale

0.559

High

566249

HSH49
Protein HSH49

1

1

High-throughput

0.536

High

548348

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

0

High-throughput

0.513

High

566126

PWP1
Periodic tryptophan protein 1

1

0

High-throughput

0.513

High

566136

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

566159

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.513

High

566161

RRP1
Ribosomal RNA-processing protein 1

1

0

High-throughput

0.513

High

566164

DBP7
ATP-dependent RNA helicase DBP7

1

0

High-throughput

0.513

High

566189

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.513

High

566214

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.513

High

566226

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.513

High

566248

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.513

High

566193

ECO1
N-acetyltransferase ECO1

1

0

Small-scale

0.505

High

485447

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.500

High

566155

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.489

High

566162

SPT23
Protein SPT23

1

0

High-throughput

0.486

High

566203

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.486

High

566129

RFA1
Replication factor A protein 1

1

0

Small-scale

0.480

High

376618

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.479

High

566128

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

566141

BMH1
Protein BMH1

1

0

High-throughput

0.479

High

566171

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.479

High

554543

HSP26
Heat shock protein 26

1

1

High-throughput

0.479

High

566124

PSA7
Probable proteasome subunit alpha type-7

1

1

High-throughput

0.479

High

566125

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.479

High

566134

PSB6
Proteasome subunit beta type-6

1

2

High-throughput

0.479

High

566142

PSB5
Proteasome subunit beta type-5

1

1

High-throughput

0.479

High

566146

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.479

High

566147

HSP79
Heat shock protein homolog SSE2

1

1

High-throughput

0.479

High

566150

KU70
ATP-dependent DNA helicase II subunit 1

1

1

High-throughput

0.479

High

566151

UFD4
Ubiquitin fusion degradation protein 4

1

1

High-throughput

0.479

High

566153

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.479

High

566154

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.479

High

566170

PSB1
Proteasome subunit beta type-1

1

1

High-throughput

0.479

High

566173

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

566178

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

1

High-throughput

0.479

High

566184

PRS4
26S proteasome regulatory subunit 4 homolog

1

1

High-throughput

0.479

High

566194

RRP41
Exosome complex component SKI6

1

1

High-throughput

0.479

High

566208

RRP46
Exosome complex component RRP46

1

2

High-throughput

0.479

High

566210

PRS10
26S proteasome subunit RPT4

1

2

High-throughput

0.479

High

566230

RPN7
26S proteasome regulatory subunit RPN7

1

1

High-throughput

0.479

High

566250

HRP1
Nuclear polyadenylated RNA-binding protein 4

1

1

High-throughput

0.479

High

141820

RPN13
26S proteasome regulatory subunit RPN13

1

0

High-throughput

0.458

High

454164

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.458

High

485633

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.458

High

490254

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.458

High

516843

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.458

High

521106

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.458

High

548502

GCN2
eIF-2-alpha kinase GCN2

1

0

High-throughput

0.458

High

566133

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

566137

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.458

High

566139

SPB1
27S pre-rRNA

1

0

High-throughput

0.458

High

566140

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

566148

BRR2
Pre-mRNA-splicing helicase BRR2

1

0

High-throughput

0.458

High

566152

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

566156

NPL4
Nuclear protein localization protein 4

1

0

High-throughput

0.458

High

566157

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.458

High

566158

UBX1
UBX domain-containing protein 1

1

0

High-throughput

0.458

High

566160

HSL1
Probable serine/threonine-protein kinase HSL1

1

0

High-throughput

0.458

High

566165

SPO14
Phospholipase D1

1

0

High-throughput

0.458

High

566169

POP7
Ribonucleases P/MRP protein subunit POP7

1

0

High-throughput

0.458

High

566172

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

566174

CSK2C
Casein kinase II subunit beta'

1

0

High-throughput

0.458

High

566180

IMB4
Importin subunit beta-4

1

0

High-throughput

0.458

High

566181

RUXG
Small nuclear ribonucleoprotein G

1

0

High-throughput

0.458

High

566182

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.458

High

566183

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.458

High

566188

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

566190

SMD3
Small nuclear ribonucleoprotein Sm D3

1

0

High-throughput

0.458

High

566191

GAT1
Transcriptional regulatory protein GAT1

1

0

High-throughput

0.458

High

566192

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

566195

NMD5
Nonsense-mediated mRNA decay protein 5

1

0

High-throughput

0.458

High

566196

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.458

High

566198

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

566199

MTR3
Exosome complex component MTR3

1

0

High-throughput

0.458

High

566200

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.458

High

566201

UFD1
Ubiquitin fusion degradation protein 1

1

0

High-throughput

0.458

High

566204

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

566205

SWC4
SWR1-complex protein 4

1

0

High-throughput

0.458

High

566207

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.458

High

566211

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.458

High

566213

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.458

High

566216

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

566217

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.458

High

566219

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.458

High

566221

TOM1
E3 ubiquitin-protein ligase TOM1

1

0

High-throughput

0.458

High

566222

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.458

High

566224

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

566228

EUC1
Transcription factor-like protein EUC1

1

0

High-throughput

0.458

High

566229

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

566231

SGD1
Suppressor of glycerol defect protein 1

1

0

High-throughput

0.458

High

566232

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

566234

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

566235

VPS74
Vacuolar protein sorting-associated protein 74

1

0

High-throughput

0.458

High

566241

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

High-throughput

0.458

High

566242

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.458

High

566144

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

2

High-throughput

0.437

High

566186

VTH1
VPS10 homolog 1

1

2

High-throughput

0.437

High

566187

EPS1
ER-retained PMA1-suppressing protein 1

1

1

High-throughput

0.437

High

566202

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.437

High

566212

YN94
Uncharacterized membrane glycoprotein YNR065C

1

2

High-throughput

0.437

High

566243

RPN5
26S proteasome regulatory subunit RPN5

1

1

High-throughput

0.437

High

566244

HSP42
Heat shock protein 42

1

1

High-throughput

0.437

High

566121

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.279

Low

566179

MRX1
MIOREX complex component 1

1

0

High-throughput

0.279

Low

566237

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.279

Low

566131

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.265

Low

566176

HPH2
Protein HPH2

1

0

High-throughput

0.265

Low

566223

YMD8
Putative nucleotide-sugar transporter YMD8

1

0

High-throughput

0.265

Low

367705

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.261

Low

566122

ADT2
ADP,ATP carrier protein 2

1

0

High-throughput

0.261

Low

566127

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

415839

HIS7
Imidazoleglycerol-phosphate dehydratase

1

0

High-throughput

0.249

Low

534446

RM31
Large ribosomal subunit protein mL60

1

0

High-throughput

0.249

Low

549698

STI1
Heat shock protein STI1

1

0

High-throughput

0.249

Low

566123

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.249

Low

566130

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.249

Low

566132

RM25
Large ribosomal subunit protein mL59

1

0

High-throughput

0.249

Low

566143

RM09
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.249

Low

566145

RM41
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

566163

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.249

Low

566167

RM10
Large ribosomal subunit protein uL15m

1

0

High-throughput

0.249

Low

566168

RM27
Large ribosomal subunit protein mL41

1

0

High-throughput

0.249

Low

566175

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.249

Low

566177

RPN3
26S proteasome regulatory subunit RPN3

1

0

High-throughput

0.249

Low

566185

PDAT
Phospholipid:diacylglycerol acyltransferase

1

0

High-throughput

0.249

Low

566215

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.249

Low

566218

MLP1
Protein MLP1

1

0

High-throughput

0.249

Low

566225

UBX2
UBX domain-containing protein 2

1

0

High-throughput

0.249

Low

566236

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

0

High-throughput

0.249

Low

566238

GUAD
Probable guanine deaminase

1

0

High-throughput

0.249

Low

566239

ISA1
Iron-sulfur assembly protein 1

1

0

High-throughput

0.249

Low

566240

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.249

Low

566246

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.249

Low

566247

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.249

Low

566135

TSR4
20S rRNA accumulation protein 4

1

0

High-throughput

0.238

Low

566209

YG3R
Putative uncharacterized protein YGR160W

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024