Protein: HDAC1
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)

Gene: HDAC1
Organism: Mus musculus
Interactions: 131
UniProt ID: O09106

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0000976 - transcription cis-regulatory region binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

148692

SIN3A
Paired amphipathic helix protein Sin3a

10

17

Small-scale

0.970

High

148672

HDAC2
Histone deacetylase 2

5

16

Small-scale

0.914

High

148739

MTA2
Metastasis-associated protein MTA2

5

20

Small-scale

0.909

High

148700

SIN3B
Paired amphipathic helix protein Sin3b

4

17

Small-scale

0.873

High

148723

RCOR1
REST corepressor 1

2

20

Small-scale

0.754

High

148744

MECP2
Methyl-CpG-binding protein 2

2

19

Small-scale

0.754

High

148718

NSD2
Histone-lysine N-methyltransferase NSD2

1

20

Small-scale

0.715

High

148709

KDM1A
Lysine-specific histone demethylase 1A

5

10

Small-scale

0.706

High

148663

SOX2
Transcription factor SOX-2

4

20

Small-scale

0.694

High

148715

KDM5B
Lysine-specific demethylase 5B

1

14

Small-scale

0.691

High

148648

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

3

8

Small-scale

0.674

High

148647

PO5F1
POU domain, class 5, transcription factor 1

3

3

High-throughput

0.667

High

148652

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

20

Small-scale

0.650

High

148708

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

Small-scale

0.646

High

148656

CEBPB
CCAAT/enhancer-binding protein beta

3

17

Small-scale

0.646

High

148639

MYOD1
Myoblast determination protein 1

3

1

Small-scale

0.640

High

148634

SP1
Transcription factor Sp1

2

20

Small-scale

0.624

High

59097

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

19

Small-scale

0.618

High

148620

HDAC1
Histone deacetylase 1

1

15

Small-scale

0.618

High

148632

HDAC3
Histone deacetylase 3

1

14

Small-scale

0.618

High

148691

PHF12
PHD finger protein 12

1

20

Small-scale

0.618

High

148713

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

Small-scale

0.618

High

148724

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.618

High

148734

BRMS1
Breast cancer metastasis-suppressor 1 homolog

1

10

Small-scale

0.618

High

148633

ZBT7A
Zinc finger and BTB domain-containing protein 7A

2

20

Small-scale

0.611

High

148696

EZH2
Histone-lysine N-methyltransferase EZH2

2

20

Small-scale

0.601

High

148666

CEBPA
CCAAT/enhancer-binding protein alpha

2

10

Small-scale

0.594

High

148728

SATB2
DNA-binding protein SATB2

2

3

Small-scale

0.588

High

148698

E2F1
Transcription factor E2F1

2

6

Small-scale

0.586

High

148729

EED
Polycomb protein EED

2

18

High-throughput

0.586

High

148640

RB
Retinoblastoma-associated protein

2

12

Small-scale

0.584

High

148678

TYY1
Transcriptional repressor protein YY1

2

11

Small-scale

0.584

High

148688

Q3UQ17
Zinc finger and BTB domain containing 16

2

9

Small-scale

0.584

High

148716

NANOG
Homeobox protein NANOG

2

11

Small-scale

0.584

High

148732

FOXP3
Forkhead box protein P3

2

16

Small-scale

0.571

High

59880

A2AWT7
Nucleolar transcription factor 1

1

20

Small-scale

0.561

High

148623

TCF21
Transcription factor 21

1

7

Small-scale

0.561

High

148655

HNF1B
Hepatocyte nuclear factor 1-beta

1

2

Small-scale

0.561

High

148665

PDX1
Pancreas/duodenum homeobox protein 1

1

5

Small-scale

0.561

High

148676

CRY1
Cryptochrome-1

1

1

Small-scale

0.561

High

148705

RBL2
Retinoblastoma-like protein 2

1

12

Small-scale

0.561

High

148730

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

9

Small-scale

0.561

High

148621

PHB2
Prohibitin-2

1

8

Small-scale

0.552

High

148625

FOG1
Zinc finger protein ZFPM1

1

14

Small-scale

0.536

High

148681

TF65
Transcription factor p65

1

20

Small-scale

0.536

High

148687

TF2L1
Transcription factor CP2-like protein 1

1

3

High-throughput

0.536

High

148699

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.536

High

148702

TLE1
Transducin-like enhancer protein 1

1

20

Small-scale

0.536

High

148712

MBB1A
Myb-binding protein 1A

1

2

Small-scale

0.536

High

148719

SALL4
Sal-like protein 4

1

7

High-throughput

0.536

High

98273

ZN431
Zinc finger protein 431

1

1

Small-scale

0.534

High

148679

GSC
Homeobox protein goosecoid

1

6

Small-scale

0.534

High

148629

GFI1B
Zinc finger protein Gfi-1b

1

9

Small-scale

0.516

High

59992

ARI1A
AT-rich interactive domain-containing protein 1A

1

10

Small-scale

0.515

High

148641

DNMT1
DNA

1

14

Small-scale

0.515

High

148720

SKOR1
SKI family transcriptional corepressor 1

1

7

Small-scale

0.515

High

148654

CREM
cAMP-responsive element modulator

1

8

Small-scale

0.501

High

148671

H4
Histone H4

1

12

Small-scale

0.501

High

148680

MSX2
Homeobox protein MSX-2

1

4

Small-scale

0.501

High

148706

Q6P5E3
Sal-like protein 1

1

8

Small-scale

0.501

High

148736

KLF13
Krueppel-like factor 13

1

20

Small-scale

0.501

High

148628

PER2
Period circadian protein homolog 2

1

11

Small-scale

0.500

High

148635

P53
Cellular tumor antigen p53

1

7

Small-scale

0.500

High

148673

BACH1
Transcription regulator protein BACH1

1

20

Small-scale

0.500

High

148726

HOP
Homeodomain-only protein

1

2

Small-scale

0.500

High

148627

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

12

Small-scale

0.484

High

148695

Q60I23
SRY

1

20

High-throughput

0.484

High

148694

RBBP7
Histone-binding protein RBBP7

1

20

High-throughput

0.481

High

148312

MNT
Max-binding protein MNT

1

20

Small-scale

0.479

High

148622

BHE40
Class E basic helix-loop-helix protein 40

1

6

Small-scale

0.479

High

148624

DAXX
Death domain-associated protein 6

1

4

Small-scale

0.479

High

148626

CFLAR
CASP8 and FADD-like apoptosis regulator

1

6

Small-scale

0.479

High

148630

SP3
Transcription factor Sp3

1

20

Small-scale

0.479

High

148631

SAP30
Histone deacetylase complex subunit SAP30

1

7

Small-scale

0.479

High

148637

IL6
Interleukin-6

1

1

Small-scale

0.479

High

148638

JUNB
Transcription factor JunB

1

13

Small-scale

0.479

High

148642

IRF1
Interferon regulatory factor 1

1

5

Small-scale

0.479

High

148643

ASSY
Argininosuccinate synthase

1

2

Small-scale

0.479

High

148644

GATA1
Erythroid transcription factor

1

15

Small-scale

0.479

High

148645

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

7

Small-scale

0.479

High

148646

IFRD1
Interferon-related developmental regulator 1

1

2

Small-scale

0.479

High

148649

CXA1
Gap junction alpha-1 protein

1

2

Small-scale

0.479

High

148650

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

148651

CCND1
G1/S-specific cyclin-D1

1

6

Small-scale

0.479

High

148653

ETS1
Protein C-ets-1

1

8

Small-scale

0.479

High

148657

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

Small-scale

0.479

High

148658

RXRA
Retinoic acid receptor RXR-alpha

1

20

Small-scale

0.479

High

148660

HES1
Transcription factor HES-1

1

6

Small-scale

0.479

High

148661

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

148662

STA5A
Signal transducer and activator of transcription 5A

1

10

Small-scale

0.479

High

148667

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

148668

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

10

Small-scale

0.479

High

148669

MO4L1
Mortality factor 4-like protein 1

1

6

Small-scale

0.479

High

148670

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

8

High-throughput

0.479

High

148674

SMYD1
Histone-lysine N-methyltransferase Smyd1

1

4

Small-scale

0.479

High

148675

SMAD4
Mothers against decapentaplegic homolog 4

1

12

Small-scale

0.479

High

148677

JDP2
Jun dimerization protein 2

1

17

Small-scale

0.479

High

148682

RELB
Transcription factor RelB

1

20

Small-scale

0.479

High

148683

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

148685

DDB1
DNA damage-binding protein 1

1

9

Small-scale

0.479

High

148686

Q3UM65
Runt-related transcription factor

1

10

Small-scale

0.479

High

148689

TET1
Methylcytosine dioxygenase TET1

1

4

Small-scale

0.479

High

148690

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.479

High

148693

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.479

High

148697

CCNE1
G1/S-specific cyclin-E1

1

2

Small-scale

0.479

High

148701

SSXT
Protein SSXT

1

16

Small-scale

0.479

High

148703

TFE3
Transcription factor E3

1

10

High-throughput

0.479

High

148704

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

19

High-throughput

0.479

High

148707

XPO1
Exportin-1

1

8

Small-scale

0.479

High

148711

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

11

Small-scale

0.479

High

148714

FACD2
Fanconi anemia group D2 protein homolog

1

1

High-throughput

0.479

High

148717

Q8BPQ2
Kruppel-like transcription factor 6

1

20

Small-scale

0.479

High

148721

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.479

High

148722

Q8C5P6
C2H2-type domain-containing protein

1

14

Small-scale

0.479

High

148727

DACT1
Dapper homolog 1

1

4

Small-scale

0.479

High

148731

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.479

High

148733

HDAC9
Histone deacetylase 9

1

18

Small-scale

0.479

High

148737

CUL3
Cullin-3

1

12

Small-scale

0.479

High

148738

CAF1A
Chromatin assembly factor 1 subunit A

1

7

High-throughput

0.479

High

148740

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

20

Small-scale

0.479

High

148742

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.479

High

148743

TF7L1
Transcription factor 7-like 1

1

20

Small-scale

0.479

High

148684

CIART
Circadian-associated transcriptional repressor

1

0

Small-scale

0.458

High

148735

GON4L
GON-4-like protein

1

0

Small-scale

0.458

High

148664

CENPC
Centromere protein C

1

6

High-throughput

0.445

High

148636

CFAD
Complement factor D

1

1

High-throughput

0.437

High

148659

KIF2A
Kinesin-like protein KIF2A

1

3

Small-scale

0.437

High

148710

DACT2
Dapper homolog 2

1

4

Small-scale

0.437

High

148725

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.437

High

148741

GBP2
Guanylate-binding protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025