Protein: UBP6
Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)

Gene: UBP6
Organism: Saccharomyces cerevisiae S288C
Interactions: 132
UniProt ID: P43593

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005838 - proteasome regulatory particle
GO:0016579 - protein deubiquitination
GO:0032434 - regulation of proteasomal ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

703815

PRS6B
26S proteasome regulatory subunit 6B homolog

6

10

High-throughput

0.945

High

797710

PRS8
26S proteasome regulatory subunit 8 homolog

5

12

Small-scale

0.925

High

771716

PRS4
26S proteasome regulatory subunit 4 homolog

4

11

High-throughput

0.896

High

797703

PRS10
26S proteasome subunit RPT4

4

14

High-throughput

0.896

High

703668

PRS6A
26S proteasome regulatory subunit 6A

3

10

High-throughput

0.839

High

477337

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

4

20

Small-scale

0.807

High

797690

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

2

17

High-throughput

0.776

High

797436

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

22

14

Small-scale

0.765

High

753859

RPN1
26S proteasome regulatory subunit RPN1

13

7

Small-scale

0.760

High

703921

PRS7
26S proteasome regulatory subunit 7 homolog

8

14

Small-scale

0.749

High

797700

RPN14
26S proteasome regulatory subunit RPN14

2

18

High-throughput

0.737

High

756959

RPN10
26S proteasome regulatory subunit RPN10

5

5

Small-scale

0.716

High

797724

RPN9
26S proteasome regulatory subunit RPN9

5

3

High-throughput

0.716

High

797730

RPN8
26S proteasome regulatory subunit RPN8

5

6

High-throughput

0.716

High

693324

RPN2
26S proteasome regulatory subunit RPN2

5

7

High-throughput

0.714

High

797735

RPN5
26S proteasome regulatory subunit RPN5

5

4

Small-scale

0.714

High

766864

RPN3
26S proteasome regulatory subunit RPN3

4

3

High-throughput

0.694

High

797736

RPN6
26S proteasome regulatory subunit RPN6

4

3

High-throughput

0.694

High

753416

ECM29
Proteasome component ECM29

4

8

Small-scale

0.687

High

604808

PSB4
Proteasome subunit beta type-4

4

14

Small-scale

0.676

High

797709

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

19

High-throughput

0.665

High

771337

PSA6
Proteasome subunit alpha type-6

3

11

High-throughput

0.662

High

797725

RPN7
26S proteasome regulatory subunit RPN7

3

4

High-throughput

0.657

High

697095

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.618

High

691485

RPN12
26S proteasome regulatory subunit RPN12

2

1

High-throughput

0.601

High

797726

CORO
Coronin-like protein

1

16

High-throughput

0.595

High

619485

PSA2
Proteasome subunit alpha type-2

2

9

High-throughput

0.584

High

141856

RPN13
26S proteasome regulatory subunit RPN13

2

0

High-throughput

0.576

High

294134

SEM1
26S proteasome complex subunit SEM1

2

0

High-throughput

0.576

High

491602

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.536

High

797696

PSD10
Probable 26S proteasome regulatory subunit p28

2

16

High-throughput

0.521

High

494267

HSP72
Heat shock protein SSA2

2

12

High-throughput

0.504

High

797727

ERFB
Palmitoyltransferase ERF2

1

1

High-throughput

0.494

High

597255

PSA7
Probable proteasome subunit alpha type-7

1

12

High-throughput

0.479

High

597333

PSA1
Proteasome subunit alpha type-1

1

12

High-throughput

0.479

High

619371

PSA3
Proteasome subunit alpha type-3

1

11

High-throughput

0.479

High

619983

PSB6
Proteasome subunit beta type-6

1

16

High-throughput

0.479

High

625945

PSB2
Proteasome subunit beta type-2

1

12

High-throughput

0.479

High

628199

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

632496

PSB3
Proteasome subunit beta type-3

1

12

High-throughput

0.479

High

675479

PSB7
Proteasome subunit beta type-7

1

15

High-throughput

0.479

High

689190

PSA5
Proteasome subunit alpha type-5

1

8

High-throughput

0.479

High

751172

PSB1
Proteasome subunit beta type-1

1

15

High-throughput

0.479

High

771371

PSA4
Proteasome subunit alpha type-4

1

10

High-throughput

0.479

High

635083

DPO4
DNA polymerase IV

1

1

High-throughput

0.470

High

659118

CAPZA
F-actin-capping protein subunit alpha

1

3

High-throughput

0.470

High

715208

TOR1
Serine/threonine-protein kinase TOR1

1

12

High-throughput

0.470

High

764081

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.470

High

797731

MDN1
Midasin

1

20

High-throughput

0.470

High

797733

YRA1
RNA annealing protein YRA1

1

7

High-throughput

0.470

High

797737

AIR2
Protein AIR2

1

2

High-throughput

0.470

High

797707

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

High-throughput

0.458

High

412790

KAPA
cAMP-dependent protein kinase type 1

1

9

High-throughput

0.457

High

419910

SNF1
Carbon catabolite-derepressing protein kinase

1

12

High-throughput

0.457

High

526259

KIN2
Serine/threonine-protein kinase KIN2

1

18

High-throughput

0.457

High

548538

GCN2
eIF-2-alpha kinase GCN2

1

9

High-throughput

0.457

High

565662

PHO85
Cyclin-dependent protein kinase PHO85

1

8

High-throughput

0.457

High

614698

KC11
Casein kinase I homolog 1

1

10

High-throughput

0.457

High

624659

CG21
G2/mitotic-specific cyclin-1

1

4

Small-scale

0.457

High

624699

CG22
G2/mitotic-specific cyclin-2

1

4

Small-scale

0.457

High

648192

KCC1
Calcium/calmodulin-dependent protein kinase I

1

3

High-throughput

0.457

High

797697

ATG1
Serine/threonine-protein kinase ATG1

1

13

High-throughput

0.457

High

797718

SKY1
Serine/threonine-protein kinase SKY1

1

20

High-throughput

0.457

High

797720

VHS1
Serine/threonine-protein kinase VHS1

1

7

High-throughput

0.457

High

797698

HUL5
E3 ubiquitin-protein ligase HUL5

1

20

Small-scale

0.445

High

366484

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.437

High

498740

RT02
Small ribosomal subunit protein uS14m

1

1

High-throughput

0.437

High

543952

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

558118

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

660797

HIBCH
Small ribosomal subunit protein mS47

1

7

High-throughput

0.437

High

694095

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

8

High-throughput

0.437

High

700179

RT04
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.437

High

707280

RT05
Small ribosomal subunit protein uS5m

1

5

High-throughput

0.437

High

744491

RT09
Small ribosomal subunit protein uS9m

1

3

High-throughput

0.437

High

797694

RT26
Small ribosomal subunit protein mS42

1

2

High-throughput

0.437

High

797695

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.437

High

797704

RT12
Small ribosomal subunit protein uS12m

1

3

High-throughput

0.437

High

797705

RT19
Small ribosomal subunit protein uS19m

1

1

High-throughput

0.437

High

797712

ULP1
Ubiquitin-like-specific protease 1

1

8

High-throughput

0.437

High

797714

ESP1
Separin

1

3

High-throughput

0.437

High

797715

RT10
Small ribosomal subunit protein uS10m

1

3

High-throughput

0.437

High

797719

ESC1
Silent chromatin protein ESC1

1

2

High-throughput

0.437

High

797734

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.437

High

511755

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.407

High

628992

SCJ1
DnaJ-related protein SCJ1

1

8

High-throughput

0.407

High

633327

MAS5
Mitochondrial protein import protein MAS5

1

8

High-throughput

0.407

High

694943

HSP7F
Heat shock protein homolog SSE1

1

17

High-throughput

0.407

High

760757

TCPG
T-complex protein 1 subunit gamma

1

10

High-throughput

0.407

High

761252

CAJ1
Protein CAJ1

1

10

High-throughput

0.407

High

766071

HSP7E
Heat shock protein SSC3, mitochondrial

1

17

High-throughput

0.407

High

797728

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

6

High-throughput

0.407

High

770368

GAT2
Protein GAT2

1

0

High-throughput

0.282

High

797699

ITC1
Imitation switch two complex protein 1

1

0

High-throughput

0.282

High

797729

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.282

High

710467

TOD6
Transcriptional regulatory protein TOD6

1

0

High-throughput

0.269

Low

797691

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.269

Low

771530

SECU
Securin

1

0

Small-scale

0.261

Low

252711

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

357310

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

498673

RT01
Small ribosomal subunit protein mS43

1

0

High-throughput

0.249

Low

520425

RT13
Small ribosomal subunit protein mS27

1

0

High-throughput

0.249

Low

568387

RTPT
Small ribosomal subunit protein mS26

1

0

High-throughput

0.249

Low

601085

RT28
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.249

Low

655134

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.249

Low

660248

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.249

Low

688299

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

731552

POC2
Proteasome assembly chaperone 2

1

0

High-throughput

0.249

Low

731953

RT22
Ribosome assembly protein RSM22, mitochondrial

1

0

High-throughput

0.249

Low

745567

RT21
Small ribosomal subunit protein bS21m

1

0

High-throughput

0.249

Low

747932

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.249

Low

754298

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.249

Low

756047

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.249

Low

762319

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

767149

RSM18
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.249

Low

774689

RT25
Small ribosomal subunit protein mS23

1

0

High-throughput

0.249

Low

791299

RT18
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.249

Low

797693

AIM23
Altered inheritance of mitochondria protein 23, mitochondrial

1

0

High-throughput

0.249

Low

797701

RT35
Small ribosomal subunit protein mS45

1

0

High-throughput

0.249

Low

797702

RT27
Small ribosomal subunit protein mS33

1

0

High-throughput

0.249

Low

797706

CAF40
Protein CAF40

1

0

High-throughput

0.249

Low

797708

RT23
Small ribosomal subunit protein mS29

1

0

High-throughput

0.249

Low

797711

RT16
Small ribosomal subunit protein bS16m

1

0

High-throughput

0.249

Low

797713

RT51
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.249

Low

797716

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.249

Low

797717

RSM28
Small ribosomal subunit protein mS46

1

0

High-throughput

0.249

Low

797721

RT08
Small ribosomal subunit protein uS8m

1

0

High-throughput

0.249

Low

797722

RT24
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

797723

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

797732

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

705331

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

797692

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024