Protein: PRS10
26S proteasome subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit)

Gene: PRS10, RPT4
Organism: Saccharomyces cerevisiae S288C
Interactions: 134
UniProt ID: P53549

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006289 - nucleotide-excision repair
GO:0008540 - proteasome regulatory particle, base subcomplex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797499

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

22

20

Small-scale

0.987

High

703700

PRS6A
26S proteasome regulatory subunit 6A

13

19

Small-scale

0.979

High

703936

PRS7
26S proteasome regulatory subunit 7 homolog

11

19

Small-scale

0.976

High

753896

RPN1
26S proteasome regulatory subunit RPN1

10

20

Small-scale

0.972

High

703831

PRS6B
26S proteasome regulatory subunit 6B homolog

9

19

Small-scale

0.971

High

775493

PSMD9
Probable 26S proteasome regulatory subunit p27

8

10

Small-scale

0.966

High

862672

PRS8
26S proteasome regulatory subunit 8 homolog

7

20

Small-scale

0.966

High

604819

PSB4
Proteasome subunit beta type-4

5

20

Small-scale

0.906

High

797703

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

4

14

High-throughput

0.896

High

697104

RAD23
UV excision repair protein RAD23

4

20

Small-scale

0.875

High

862680

RPN7
26S proteasome regulatory subunit RPN7

3

20

High-throughput

0.855

High

748954

HSM3
DNA mismatch repair protein HSM3

3

2

Small-scale

0.848

High

837202

PSD10
Probable 26S proteasome regulatory subunit p28

3

11

Small-scale

0.847

High

771724

PRS4
26S proteasome regulatory subunit 4 homolog

2

19

High-throughput

0.776

High

862687

RPN8
26S proteasome regulatory subunit RPN8

2

20

High-throughput

0.776

High

619498

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.754

High

680892

HS104
Heat shock protein 104

2

7

High-throughput

0.737

High

862689

RPN5
26S proteasome regulatory subunit RPN5

6

20

Small-scale

0.730

High

756990

RPN10
26S proteasome regulatory subunit RPN10

5

17

Small-scale

0.718

High

294149

SEM1
26S proteasome complex subunit SEM1

5

2

Small-scale

0.706

High

860034

RPN14
26S proteasome regulatory subunit RPN14

4

17

Small-scale

0.696

High

691493

RPN12
26S proteasome regulatory subunit RPN12

4

7

High-throughput

0.694

High

862691

RPN6
26S proteasome regulatory subunit RPN6

4

20

High-throughput

0.694

High

862669

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

12

High-throughput

0.691

High

381563

GAL4
Regulatory protein GAL4

3

2

Small-scale

0.674

High

862677

RPN9
26S proteasome regulatory subunit RPN9

3

17

High-throughput

0.662

High

753427

ECM29
Proteasome component ECM29

3

9

High-throughput

0.656

High

693337

RPN2
26S proteasome regulatory subunit RPN2

3

20

High-throughput

0.650

High

477391

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

578551

SEC18
Vesicular-fusion protein SEC18

1

20

High-throughput

0.618

High

597258

PSA7
Probable proteasome subunit alpha type-7

1

20

High-throughput

0.618

High

597336

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.618

High

619375

PSA3
Proteasome subunit alpha type-3

1

20

High-throughput

0.618

High

625948

PSB2
Proteasome subunit beta type-2

1

20

High-throughput

0.618

High

675428

PSB5
Proteasome subunit beta type-5

1

20

High-throughput

0.618

High

675482

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

689194

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

751173

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

771342

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

771373

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.618

High

862675

RUVB1
RuvB-like protein 1

1

9

High-throughput

0.618

High

862692

RUVB2
RuvB-like protein 2

1

9

High-throughput

0.618

High

141864

RPN13
26S proteasome regulatory subunit RPN13

2

2

High-throughput

0.611

High

766872

RPN3
26S proteasome regulatory subunit RPN3

2

16

High-throughput

0.601

High

628313

SIS1
Protein SIS1

2

12

High-throughput

0.584

High

425369

PHO4
Phosphate system positive regulatory protein PHO4

1

2

Small-scale

0.561

High

454640

TBA3
Tubulin alpha-3 chain

1

9

High-throughput

0.536

High

594351

PP11
Serine/threonine-protein phosphatase PP1-1

1

12

High-throughput

0.536

High

689366

ARP2
Actin-related protein 2

1

8

High-throughput

0.536

High

693139

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

6

Small-scale

0.536

High

746524

IMB2
Importin subunit beta-2

1

4

High-throughput

0.536

High

862673

ESC1
Silent chromatin protein ESC1

2

6

High-throughput

0.533

High

416798

CDC31
Cell division control protein 31

1

7

Small-scale

0.501

High

703163

UFD4
Ubiquitin fusion degradation protein 4

1

20

Small-scale

0.501

High

862666

TMEDA
Endoplasmic reticulum vesicle protein 25

1

4

High-throughput

0.489

High

862678

UTP5
U3 small nucleolar RNA-associated protein 5

1

13

High-throughput

0.489

High

862686

SHS1
Seventh homolog of septin 1

1

6

High-throughput

0.489

High

728729

BDF1
Bromodomain-containing factor 1

1

7

High-throughput

0.481

High

745424

RTG3
Retrograde regulation protein 3

1

1

High-throughput

0.481

High

810345

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

6

High-throughput

0.481

High

862681

NKP2
Inner kinetochore subunit NKP2

1

1

High-throughput

0.481

High

339767

CDK1
Cyclin-dependent kinase 1

1

9

High-throughput

0.479

High

366664

HSP82
ATP-dependent molecular chaperone HSP82

1

15

High-throughput

0.479

High

407212

RS3
Small ribosomal subunit protein uS3

1

8

High-throughput

0.479

High

512183

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.479

High

521148

RAD50
DNA repair protein RAD50

1

3

High-throughput

0.479

High

530137

ATN1
Sodium/potassium exporting P-type ATPase 1

1

9

High-throughput

0.479

High

544160

HSC82
ATP-dependent molecular chaperone HSC82

1

15

High-throughput

0.479

High

566210

EST1
Telomere elongation protein EST1

1

2

High-throughput

0.479

High

606087

RAD53
Serine/threonine-protein kinase RAD53

1

5

High-throughput

0.479

High

606710

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.479

High

638823

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

662902

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

688346

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

692044

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

692855

SPT16
FACT complex subunit SPT16

1

2

Small-scale

0.479

High

716303

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

730870

CENPA
Histone H3-like centromeric protein CSE4

1

8

High-throughput

0.479

High

742915

GBLP
Small ribosomal subunit protein RACK1

1

13

High-throughput

0.479

High

811188

MPS3
Spindle pole body assembly component MPS3

1

3

High-throughput

0.479

High

822888

VATG
V-type proton ATPase subunit G

1

3

High-throughput

0.479

High

862664

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

11

High-throughput

0.479

High

862665

APJ1
J domain-containing protein APJ1

1

12

High-throughput

0.479

High

862668

CDC14
Tyrosine-protein phosphatase CDC14

1

13

High-throughput

0.479

High

862674

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

3

High-throughput

0.479

High

862679

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

862682

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

3

High-throughput

0.479

High

862683

TFC6
Transcription factor tau 91 kDa subunit

1

3

High-throughput

0.479

High

862694

SMC6
Structural maintenance of chromosomes protein 6

1

2

High-throughput

0.479

High

862670

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.460

High

862684

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.460

High

862693

TMA17
Translation machinery-associated protein 17

1

0

High-throughput

0.460

High

862667

SEN1
Helicase SEN1

1

0

High-throughput

0.458

High

862676

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

412579

CDC7
Cell division control protein 7

1

20

Small-scale

0.445

High

633437

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.445

High

690238

CDC3
Cell division control protein 3

1

4

High-throughput

0.439

High

759251

END3
Actin cytoskeleton-regulatory complex protein END3

1

3

High-throughput

0.439

High

767529

TSC11
Target of rapamycin complex 2 subunit TSC11

1

4

High-throughput

0.439

High

861367

AP18B
Clathrin coat assembly protein AP180B

1

1

High-throughput

0.439

High

862690

GYP5
GTPase-activating protein GYP5

1

3

High-throughput

0.439

High

358180

RS17A
Small ribosomal subunit protein eS17A

1

5

High-throughput

0.437

High

383266

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.437

High

405743

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.437

High

408033

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.437

High

413630

RS14A
Small ribosomal subunit protein uS11A

1

5

High-throughput

0.437

High

426069

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.437

High

471172

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

472313

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

482377

RS18A
Small ribosomal subunit protein uS13A

1

3

High-throughput

0.437

High

523296

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

5

Small-scale

0.437

High

524400

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

632000

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.437

High

634709

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

645564

RS7A
Small ribosomal subunit protein eS7A

1

6

High-throughput

0.437

High

706402

RS3A1
Small ribosomal subunit protein eS1A

1

6

High-throughput

0.437

High

730039

RS27A
Small ribosomal subunit protein eS27A

1

5

High-throughput

0.437

High

734142

PXL1
Paxillin-like protein 1

1

3

High-throughput

0.437

High

752578

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

762421

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

765014

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

5

High-throughput

0.437

High

773963

MLP2
Protein MLP2

1

8

High-throughput

0.437

High

792523

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.437

High

820084

RS12
Small ribosomal subunit protein eS12

1

5

High-throughput

0.437

High

862671

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

862685

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

862688

RS10A
Small ribosomal subunit protein eS10A

1

8

High-throughput

0.437

High

691834

EI2BB
Translation initiation factor eIF2B subunit beta

1

2

High-throughput

0.407

High

693228

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.282

High

791218

SKP2
F-box protein SKP2

1

0

High-throughput

0.279

Low

563972

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.251

Low

746760

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

791255

KRI1
Protein KRI1

1

0

High-throughput

0.251

Low

797082

FMP32
Protein FMP32, mitochondrial

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024