Protein: PRS8
26S proteasome regulatory subunit 8 homolog (Protein CIM3) (Protein SUG1) (Tat-binding protein TBY1)

Gene: PRS8, RPT6
Organism: Saccharomyces cerevisiae S288C
Interactions: 214
UniProt ID: Q01939

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006289 - nucleotide-excision repair
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797537

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

27

20

Small-scale

0.991

High

703948

PRS7
26S proteasome regulatory subunit 7 homolog

18

19

Small-scale

0.987

High

753922

RPN1
26S proteasome regulatory subunit RPN1

15

20

Small-scale

0.983

High

703841

PRS6B
26S proteasome regulatory subunit 6B homolog

11

19

Small-scale

0.978

High

697108

RAD23
UV excision repair protein RAD23

11

20

Small-scale

0.975

High

862672

PRS10
26S proteasome subunit RPT4

7

20

Small-scale

0.966

High

703714

PRS6A
26S proteasome regulatory subunit 6A

8

19

Small-scale

0.964

High

604826

PSB4
Proteasome subunit beta type-4

9

20

Small-scale

0.963

High

837206

PSD10
Probable 26S proteasome regulatory subunit p28

7

10

Small-scale

0.963

High

748957

HSM3
DNA mismatch repair protein HSM3

7

2

Small-scale

0.956

High

968083

RPN7
26S proteasome regulatory subunit RPN7

5

20

High-throughput

0.927

High

771730

PRS4
26S proteasome regulatory subunit 4 homolog

5

19

Small-scale

0.925

High

775495

PSMD9
Probable 26S proteasome regulatory subunit p27

5

11

Small-scale

0.925

High

797710

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

12

Small-scale

0.925

High

968091

RPN8
26S proteasome regulatory subunit RPN8

5

20

Small-scale

0.916

High

675430

PSB5
Proteasome subunit beta type-5

3

20

Small-scale

0.817

High

705546

HSP78
Heat shock protein 78, mitochondrial

2

6

High-throughput

0.793

High

968102

RUVB2
RuvB-like protein 2

2

5

High-throughput

0.789

High

968066

PRS8
26S proteasome regulatory subunit 8 homolog

2

19

Small-scale

0.776

High

477414

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

20

High-throughput

0.768

High

860037

RPN14
26S proteasome regulatory subunit RPN14

10

14

Small-scale

0.760

High

968088

RIX7
Ribosome biogenesis ATPase RIX7

2

11

High-throughput

0.759

High

619382

PSA3
Proteasome subunit alpha type-3

2

20

Small-scale

0.754

High

619501

PSA2
Proteasome subunit alpha type-2

2

20

High-throughput

0.754

High

625950

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.754

High

757011

RPN10
26S proteasome regulatory subunit RPN10

7

16

Small-scale

0.746

High

693349

RPN2
26S proteasome regulatory subunit RPN2

7

20

Small-scale

0.737

High

691495

RPN12
26S proteasome regulatory subunit RPN12

6

8

Small-scale

0.732

High

968098

RPN5
26S proteasome regulatory subunit RPN5

6

20

Small-scale

0.732

High

968100

RPN6
26S proteasome regulatory subunit RPN6

5

20

High-throughput

0.716

High

968074

RPN9
26S proteasome regulatory subunit RPN9

5

16

Small-scale

0.714

High

294154

SEM1
26S proteasome complex subunit SEM1

5

2

Small-scale

0.706

High

381566

GAL4
Regulatory protein GAL4

4

2

Small-scale

0.694

High

703170

UFD4
Ubiquitin fusion degradation protein 4

3

20

Small-scale

0.681

High

527040

TBP
TATA-box-binding protein

3

5

Small-scale

0.672

High

420513

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

3

1

High-throughput

0.667

High

141866

RPN13
26S proteasome regulatory subunit RPN13

3

2

Small-scale

0.662

High

753435

ECM29
Proteasome component ECM29

3

9

High-throughput

0.656

High

492161

HSP71
Heat shock protein SSA1

3

11

High-throughput

0.624

High

657270

URA7
CTP synthase 1

2

3

High-throughput

0.621

High

680057

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

1

Small-scale

0.621

High

597263

PSA7
Probable proteasome subunit alpha type-7

1

20

High-throughput

0.618

High

597340

PSA1
Proteasome subunit alpha type-1

1

20

High-throughput

0.618

High

619984

PSB6
Proteasome subunit beta type-6

1

20

High-throughput

0.618

High

632499

PSB3
Proteasome subunit beta type-3

1

20

High-throughput

0.618

High

636718

CDC48
Cell division control protein 48

1

11

High-throughput

0.618

High

675486

PSB7
Proteasome subunit beta type-7

1

20

High-throughput

0.618

High

680937

HS104
Heat shock protein 104

1

4

High-throughput

0.618

High

689203

PSA5
Proteasome subunit alpha type-5

1

20

High-throughput

0.618

High

751176

PSB1
Proteasome subunit beta type-1

1

20

High-throughput

0.618

High

771348

PSA6
Proteasome subunit alpha type-6

1

20

High-throughput

0.618

High

771378

PSA4
Proteasome subunit alpha type-4

1

20

High-throughput

0.618

High

819481

DSK2
Ubiquitin domain-containing protein DSK2

1

20

Small-scale

0.618

High

968072

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.618

High

772265

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.613

High

440910

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

1

High-throughput

0.601

High

628377

SIS1
Protein SIS1

2

7

High-throughput

0.601

High

766878

RPN3
26S proteasome regulatory subunit RPN3

2

14

High-throughput

0.601

High

859305

HUL5
E3 ubiquitin-protein ligase HUL5

2

19

High-throughput

0.601

High

968093

BMS1
Ribosome biogenesis protein BMS1

1

0

High-throughput

0.586

High

412585

CDC7
Cell division control protein 7

2

20

Small-scale

0.584

High

587321

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

Small-scale

0.578

High

366752

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.571

High

425375

PHO4
Phosphate system positive regulatory protein PHO4

1

1

Small-scale

0.561

High

715375

SPT7
Transcriptional activator SPT7

1

4

Small-scale

0.561

High

454652

TBA3
Tubulin alpha-3 chain

1

2

High-throughput

0.536

High

512388

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.536

High

521153

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.536

High

676292

XPO1
Exportin-1

1

1

High-throughput

0.536

High

693147

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

Small-scale

0.536

High

968068

GCN5
Histone acetyltransferase GCN5

1

5

High-throughput

0.536

High

959842

NUM1
Nuclear migration protein NUM1

2

3

High-throughput

0.535

High

968070

ESC1
Silent chromatin protein ESC1

2

5

High-throughput

0.533

High

636172

NOT1
General negative regulator of transcription subunit 1

1

2

Small-scale

0.515

High

624158

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.513

High

713716

NOT4
General negative regulator of transcription subunit 4

1

0

Small-scale

0.512

High

416802

CDC31
Cell division control protein 31

1

4

Small-scale

0.501

High

614774

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.501

High

409673

KAPC
cAMP-dependent protein kinase type 3

1

8

High-throughput

0.500

High

439675

SPS1
Sporulation-specific protein 1

1

7

High-throughput

0.500

High

607324

RFA1
Replication factor A protein 1

1

6

High-throughput

0.500

High

861487

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.500

High

865839

CBK1
Serine/threonine-protein kinase CBK1

1

6

High-throughput

0.500

High

961901

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

6

High-throughput

0.500

High

968078

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.500

High

862521

SOK2
Protein SOK2

1

0

High-throughput

0.493

High

864589

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.489

High

873176

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.489

High

605682

KIN3
Serine/threonine-protein kinase KIN3

1

13

High-throughput

0.481

High

778470

MAD1
Spindle assembly checkpoint component MAD1

1

2

High-throughput

0.481

High

562424

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.479

High

597589

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.479

High

599985

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.479

High

611021

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.479

High

640323

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.479

High

968096

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.479

High

407255

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

431147

CDC4
Cell division control protein 4

1

13

Small-scale

0.479

High

544264

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

561052

EF3A
Elongation factor 3A

1

1

High-throughput

0.479

High

606723

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

633889

SGF29
SAGA-associated factor 29

1

1

Small-scale

0.479

High

663067

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

688382

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

692057

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

2

High-throughput

0.479

High

716325

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

730667

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.479

High

730890

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.479

High

731554

POC2
Proteasome assembly chaperone 2

1

2

High-throughput

0.479

High

742945

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.479

High

744670

TAF5
Transcription initiation factor TFIID subunit 5

1

8

Small-scale

0.479

High

747935

UMP1
Proteasome maturation factor UMP1

1

2

High-throughput

0.479

High

797324

BLM10
Proteasome activator BLM10

1

7

High-throughput

0.479

High

811206

MPS3
Spindle pole body assembly component MPS3

1

2

High-throughput

0.479

High

822902

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

865880

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

9

High-throughput

0.479

High

866410

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

968067

TOM1
E3 ubiquitin-protein ligase TOM1

1

10

High-throughput

0.479

High

968069

RPN4
Protein RPN4

1

2

Small-scale

0.479

High

968071

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

968073

CTK1
CTD kinase subunit alpha

1

8

Small-scale

0.479

High

968076

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

968085

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

968086

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

968094

CDC53
Cell division control protein 53

1

7

Small-scale

0.479

High

968095

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

515006

RNA1
Ran GTPase-activating protein 1

1

0

High-throughput

0.460

High

708043

NUF2
Kinetochore protein NUF2

1

0

High-throughput

0.460

High

748299

CENPU
Inner kinetochore subunit AME1

1

0

High-throughput

0.460

High

752808

SYSM
Serine--tRNA ligase, mitochondrial

1

0

High-throughput

0.460

High

766818

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

812425

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.460

High

968084

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.460

High

375481

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

516316

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.458

High

692880

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.458

High

746594

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

777136

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.458

High

797188

EPL1
Enhancer of polycomb-like protein 1

1

0

Small-scale

0.458

High

968089

SGO1
Shugoshin

1

0

High-throughput

0.458

High

968103

MEX67
mRNA export factor MEX67

1

0

Small-scale

0.458

High

579442

GBB
Guanine nucleotide-binding protein subunit beta

1

10

High-throughput

0.457

High

690336

CDC11
Cell division control protein 11

1

3

High-throughput

0.457

High

748379

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.457

High

784413

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.457

High

339798

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.445

High

450155

HSP73
Heat shock protein SSA3

1

11

High-throughput

0.445

High

494737

HSP72
Heat shock protein SSA2

1

11

High-throughput

0.445

High

560770

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.445

High

633497

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

693419

SMI1
Cell wall assembly regulator SMI1

1

1

High-throughput

0.445

High

695327

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

757455

SPT8
Transcription factor SPT8

1

1

High-throughput

0.445

High

761287

CAJ1
Protein CAJ1

1

8

High-throughput

0.445

High

769217

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

811433

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.445

High

812008

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.445

High

865741

NOP13
Nucleolar protein 13

1

4

High-throughput

0.445

High

968082

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

12

High-throughput

0.445

High

759260

END3
Actin cytoskeleton-regulatory complex protein END3

1

2

High-throughput

0.439

High

767536

TSC11
Target of rapamycin complex 2 subunit TSC11

1

2

High-throughput

0.439

High

968077

VPS20
Vacuolar protein sorting-associated protein 20

1

1

High-throughput

0.439

High

358213

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

383304

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

408068

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

426103

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

471205

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472351

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

479806

RS4A
Small ribosomal subunit protein eS4A

1

2

Small-scale

0.437

High

480263

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

480828

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

482408

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

523302

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

5

Small-scale

0.437

High

632037

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.437

High

634736

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

636234

FUB1
Silencing boundary-establishment protein FUB1

1

2

High-throughput

0.437

High

645600

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.437

High

687462

EF2
Elongation factor 2

1

2

High-throughput

0.437

High

700577

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

701046

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

706437

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.437

High

730071

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

752614

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

762479

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

765903

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

1

High-throughput

0.437

High

773974

MLP2
Protein MLP2

1

5

High-throughput

0.437

High

776491

RLP7
Ribosome biogenesis protein RLP7

1

5

High-throughput

0.437

High

792548

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

820119

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.437

High

860073

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

1

High-throughput

0.437

High

967704

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

968080

POC1
Proteasome chaperone 1

1

2

High-throughput

0.437

High

968087

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

968092

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

389653

DNLI1
DNA ligase 1

1

0

High-throughput

0.426

High

612264

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

629347

MSH3
DNA mismatch repair protein MSH3

1

0

High-throughput

0.426

High

693561

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.426

High

715620

SQT1
Ribosome assembly protein SQT1

1

9

High-throughput

0.407

High

775650

DJP1
DnaJ-like protein 1

1

8

High-throughput

0.407

High

568903

HPR1
THO complex subunit HPR1

2

0

Small-scale

0.310

High

701233

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

Small-scale

0.282

High

968097

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

0

High-throughput

0.269

Low

758695

TEM1
Protein TEM1

1

0

High-throughput

0.261

Low

968101

LAS17
Proline-rich protein LAS17

1

0

High-throughput

0.261

Low

516903

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.251

Low

696979

YEF3
Uncharacterized protein YEL043W

1

0

High-throughput

0.251

Low

968081

ENT2
Epsin-2

1

0

High-throughput

0.251

Low

968090

MPC54
Meiotic plaque component protein 54

1

0

High-throughput

0.251

Low

762106

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.232

Low

968075

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.232

Low

968079

SNO4
Probable glutathione-independent glyoxalase SNO4

1

0

High-throughput

0.232

Low

968099

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024