Protein: CBL
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)

Gene: CBL
Organism: Mus musculus
Interactions: 152
UniProt ID: P22682

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0001784 - phosphotyrosine residue binding
GO:0005509 - calcium ion binding
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

651477

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

16

20

Small-scale

0.759

High

651540

CRK
Adapter molecule crk

11

20

Small-scale

0.752

High

651529

GRB2
Growth factor receptor-bound protein 2

8

20

Small-scale

0.744

High

651515

EGFR
Epidermal growth factor receptor

8

20

Small-scale

0.741

High

651520

CBLB
E3 ubiquitin-protein ligase CBL-B

2

11

Small-scale

0.737

High

431323

SRC
Proto-oncogene tyrosine-protein kinase Src

6

20

Small-scale

0.737

High

651496

CRKL
Crk-like protein

7

20

Small-scale

0.736

High

651485

FYN
Tyrosine-protein kinase Fyn

6

20

Small-scale

0.722

High

362435

ABL1
Tyrosine-protein kinase ABL1

4

20

Small-scale

0.692

High

465767

HCK
Tyrosine-protein kinase HCK

3

20

Small-scale

0.678

High

651476

LYN
Tyrosine-protein kinase Lyn

4

20

Small-scale

0.676

High

651580

SH2B2
SH2B adapter protein 2

4

20

Small-scale

0.671

High

651587

ITSN1
Intersectin-1

3

20

Small-scale

0.650

High

431947

PGFRB
Platelet-derived growth factor receptor beta

3

20

Small-scale

0.646

High

440271

LCK
Proto-oncogene tyrosine-protein kinase LCK

3

20

Small-scale

0.640

High

651539

SRBS1
Sorbin and SH3 domain-containing protein 1

3

20

Small-scale

0.640

High

651578

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

3

3

Small-scale

0.633

High

651582

CD2AP
CD2-associated protein

3

20

Small-scale

0.629

High

651559

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.618

High

651484

VGFR1
Vascular endothelial growth factor receptor 1

2

20

Small-scale

0.601

High

571266

FGR
Tyrosine-protein kinase Fgr

2

20

Small-scale

0.584

High

651564

NCK1
SH2/SH3 adapter protein Nck1

2

20

Small-scale

0.584

High

651483

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

14

Small-scale

0.571

High

651502

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.571

High

651535

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

2

Small-scale

0.571

High

651561

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.571

High

651491

ZAP70
Tyrosine-protein kinase ZAP-70

2

20

Small-scale

0.563

High

651563

PAXI
Paxillin

1

12

Small-scale

0.561

High

561277

CD5
T-cell surface glycoprotein CD5

1

2

High-throughput

0.536

High

651513

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.536

High

236556

ITB3
Integrin beta-3

1

4

High-throughput

0.501

High

478494

ITB1
Integrin beta-1

1

4

High-throughput

0.501

High

651526

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.501

High

651543

RIGI
Antiviral innate immune response receptor RIG-I

1

10

Small-scale

0.500

High

651522

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.479

High

148333

O08797
Leukocyte elastase inhibitor

1

1

Small-scale

0.479

High

204642

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

9

Small-scale

0.479

High

266842

ATX2
Ataxin-2

1

10

Small-scale

0.479

High

431449

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.479

High

449231

TNFA
Tumor necrosis factor

1

2

Small-scale

0.479

High

464656

SPTA1
Spectrin alpha chain, erythrocytic 1

1

16

Small-scale

0.479

High

483857

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

Small-scale

0.479

High

651480

TNR5
Tumor necrosis factor receptor superfamily member 5

1

9

Small-scale

0.479

High

651492

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

13

Small-scale

0.479

High

651497

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

651510

TRAF6
TNF receptor-associated factor 6

1

18

Small-scale

0.479

High

651511

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.479

High

651517

ITK
Tyrosine-protein kinase ITK/TSK

1

20

Small-scale

0.479

High

651518

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

Small-scale

0.479

High

651519

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

651537

TGFR2
TGF-beta receptor type-2

1

2

Small-scale

0.479

High

651538

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.479

High

651550

DLG1
Disks large homolog 1

1

4

Small-scale

0.479

High

651560

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.479

High

651583

SPY2
Protein sprouty homolog 2

1

8

Small-scale

0.479

High

651584

DOK3
Docking protein 3

1

8

Small-scale

0.479

High

148473

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.445

High

205335

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.445

High

205658

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

8

High-throughput

0.445

High

205700

PSB10
Proteasome subunit beta type-10

1

7

High-throughput

0.445

High

236806

LAT
Linker for activation of T-cells family member 1

1

2

High-throughput

0.445

High

313429

GRAP2
GRB2-related adaptor protein 2

1

20

High-throughput

0.445

High

446487

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.445

High

449212

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

9

High-throughput

0.445

High

574826

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

2

High-throughput

0.445

High

575876

ANXA6
Annexin A6

1

5

High-throughput

0.445

High

590972

LEG1
Galectin-1

1

5

High-throughput

0.445

High

625159

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.445

High

651474

CBX3
Chromobox protein homolog 3

1

11

High-throughput

0.445

High

651479

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

5

High-throughput

0.445

High

651481

PSB8
Proteasome subunit beta type-8

1

8

High-throughput

0.445

High

651482

HMGB2
High mobility group protein B2

1

14

High-throughput

0.445

High

651486

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.445

High

651487

STAT1
Signal transducer and activator of transcription 1

1

4

High-throughput

0.445

High

651488

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

8

High-throughput

0.445

High

651489

TCPQ
T-complex protein 1 subunit theta

1

13

High-throughput

0.445

High

651490

H11
Histone H1.1

1

4

High-throughput

0.445

High

651493

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.445

High

651494

CAZA2
F-actin-capping protein subunit alpha-2

1

6

High-throughput

0.445

High

651495

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.445

High

651499

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

High-throughput

0.445

High

651501

RS15A
Small ribosomal subunit protein uS8

1

3

High-throughput

0.445

High

651504

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

6

High-throughput

0.445

High

651505

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.445

High

651506

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.445

High

651507

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

651509

1433F
14-3-3 protein eta

1

20

High-throughput

0.445

High

651514

TBB5
Tubulin beta-5 chain

1

12

High-throughput

0.445

High

651516

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

5

High-throughput

0.445

High

651523

DDB1
DNA damage-binding protein 1

1

3

High-throughput

0.445

High

651524

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.445

High

651527

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.445

High

651528

ACACA
Acetyl-CoA carboxylase 1

1

11

High-throughput

0.445

High

651532

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

20

High-throughput

0.445

High

651536

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

High-throughput

0.445

High

651544

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.445

High

651545

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.445

High

651547

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.445

High

651549

SIG10
Sialic acid-binding Ig-like lectin 10

1

3

Small-scale

0.445

High

651554

SYLC
Leucine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.445

High

651555

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

8

High-throughput

0.445

High

651557

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

4

High-throughput

0.445

High

651565

SYK
Lysine--tRNA ligase

1

5

High-throughput

0.445

High

651569

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.445

High

651572

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

4

High-throughput

0.445

High

651574

F162A
Protein FAM162A

1

1

High-throughput

0.445

High

651579

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

6

Small-scale

0.445

High

651581

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.445

High

651585

TPSN
Tapasin

1

1

High-throughput

0.445

High

651588

ITSN2
Intersectin-2

1

20

High-throughput

0.445

High

398097

CFAD
Complement factor D

1

3

High-throughput

0.437

High

591101

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

651475

IRF8
Interferon regulatory factor 8

1

6

High-throughput

0.437

High

651531

SLAP1
Src-like-adapter

1

20

Small-scale

0.437

High

651542

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

13

Small-scale

0.437

High

651546

SYNEM
Synemin

1

16

Small-scale

0.437

High

651556

Q8C5V7
CRK SH3-binding GNRP

1

5

Small-scale

0.437

High

651568

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

Small-scale

0.437

High

148781

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.426

High

651530

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.426

High

651573

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

380236

HA1D
H-2 class I histocompatibility antigen, K-D alpha chain

1

1

High-throughput

0.407

High

549374

ITB2
Integrin beta-2

1

4

High-throughput

0.407

High

586397

H12
Histone H1.2

1

4

High-throughput

0.407

High

603145

PTBP1
Polypyrimidine tract-binding protein 1

1

3

High-throughput

0.407

High

651478

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

5

High-throughput

0.407

High

651498

ADT2
ADP/ATP translocase 2

1

4

High-throughput

0.407

High

651500

PRS8
26S proteasome regulatory subunit 8

1

9

High-throughput

0.407

High

651503

PRS10
26S proteasome regulatory subunit 10B

1

9

High-throughput

0.407

High

651508

TBB4B
Tubulin beta-4B chain

1

12

High-throughput

0.407

High

651512

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

1

High-throughput

0.407

High

651521

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

5

High-throughput

0.407

High

651525

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

6

High-throughput

0.407

High

651533

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

2

High-throughput

0.407

High

651534

SERA
D-3-phosphoglycerate dehydrogenase

1

7

High-throughput

0.407

High

651541

CLH1
Clathrin heavy chain 1

1

2

High-throughput

0.407

High

651548

MOGS
Mannosyl-oligosaccharide glucosidase

1

1

High-throughput

0.407

High

651551

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.407

High

651553

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

1

High-throughput

0.407

High

651562

VIGLN
Vigilin

1

7

High-throughput

0.407

High

651566

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

6

High-throughput

0.407

High

651567

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

9

High-throughput

0.407

High

651570

CYB5B
Cytochrome b5 type B

1

1

High-throughput

0.407

High

651571

GRAP
GRB2-related adapter protein

1

20

High-throughput

0.407

High

651575

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

High-throughput

0.407

High

651576

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

5

High-throughput

0.407

High

651577

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.407

High

651586

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

14

High-throughput

0.407

High

267217

DIAP2
Protein diaphanous homolog 2

1

0

High-throughput

0.232

Low

360497

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

651552

THMS1
Protein THEMIS

1

0

Small-scale

0.232

Low

651558

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025