Protein: RPN5
26S proteasome regulatory subunit RPN5 (Proteasome non-ATPase subunit 5)

Gene: RPN5
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: Q12250

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0000502 - proteasome complex
GO:0005737 - cytoplasm
GO:0008180 - COP9 signalosome
GO:0008541 - proteasome regulatory particle, lid subcomplex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

797641

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

34

20

Small-scale

0.993

High

1015374

RPN6
26S proteasome regulatory subunit RPN6

20

19

Small-scale

0.987

High

996267

RPN8
26S proteasome regulatory subunit RPN8

14

20

Small-scale

0.985

High

978511

RPN9
26S proteasome regulatory subunit RPN9

15

20

Small-scale

0.984

High

691508

RPN12
26S proteasome regulatory subunit RPN12

10

2

Small-scale

0.975

High

985894

RPN7
26S proteasome regulatory subunit RPN7

10

20

Small-scale

0.974

High

766898

RPN3
26S proteasome regulatory subunit RPN3

10

10

Small-scale

0.974

High

294167

SEM1
26S proteasome complex subunit SEM1

7

1

Small-scale

0.956

High

1015375

CSN5
COP9 signalosome complex subunit 5

5

20

Small-scale

0.922

High

753984

RPN1
26S proteasome regulatory subunit RPN1

11

17

Small-scale

0.756

High

604843

PSB4
Proteasome subunit beta type-4

10

20

Small-scale

0.754

High

703865

PRS6B
26S proteasome regulatory subunit 6B homolog

7

20

Small-scale

0.747

High

757048

RPN10
26S proteasome regulatory subunit RPN10

7

5

Small-scale

0.747

High

693376

RPN2
26S proteasome regulatory subunit RPN2

7

16

Small-scale

0.746

High

703974

PRS7
26S proteasome regulatory subunit 7 homolog

7

20

Small-scale

0.745

High

703761

PRS6A
26S proteasome regulatory subunit 6A

7

20

Small-scale

0.744

High

1015369

RPN5
26S proteasome regulatory subunit RPN5

2

17

Small-scale

0.737

High

771750

PRS4
26S proteasome regulatory subunit 4 homolog

6

20

Small-scale

0.734

High

968098

PRS8
26S proteasome regulatory subunit 8 homolog

6

20

Small-scale

0.732

High

862689

PRS10
26S proteasome subunit RPT4

6

20

Small-scale

0.730

High

978162

CSN9
COP9 signalosome complex subunit 9

7

0

Small-scale

0.717

High

141879

RPN13
26S proteasome regulatory subunit RPN13

5

1

Small-scale

0.714

High

797735

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

5

4

Small-scale

0.714

High

753453

ECM29
Proteasome component ECM29

5

3

Small-scale

0.712

High

748965

HSM3
DNA mismatch repair protein HSM3

5

1

Small-scale

0.709

High

860043

RPN14
26S proteasome regulatory subunit RPN14

4

6

Small-scale

0.694

High

597354

PSA1
Proteasome subunit alpha type-1

4

19

Small-scale

0.691

High

619991

PSB6
Proteasome subunit beta type-6

4

20

Small-scale

0.691

High

751186

PSB1
Proteasome subunit beta type-1

4

20

Small-scale

0.691

High

771360

PSA6
Proteasome subunit alpha type-6

4

20

Small-scale

0.691

High

771393

PSA4
Proteasome subunit alpha type-4

4

20

Small-scale

0.686

High

1015372

CSN10
COP9 signalosome complex subunit 10

4

1

Small-scale

0.683

High

675446

PSB5
Proteasome subunit beta type-5

3

20

Small-scale

0.662

High

979427

CSI1
Cop9 signalosome-interactor 1

4

0

Small-scale

0.654

High

837214

PSD10
Probable 26S proteasome regulatory subunit p28

5

3

Small-scale

0.650

High

619523

PSA2
Proteasome subunit alpha type-2

3

19

Small-scale

0.640

High

774911

CSN11
Cop9 signalosome complex subunit 11

3

0

Small-scale

0.634

High

1015376

SKS1
Serine/threonine-protein kinase SKS1

2

1

Small-scale

0.590

High

988615

SWA2
Auxilin-like clathrin uncoating factor SWA2

2

3

High-throughput

0.588

High

812251

CSN12
Cop9 signalosome complex subunit 12

1

0

Small-scale

0.586

High

597278

PSA7
Probable proteasome subunit alpha type-7

2

20

Small-scale

0.584

High

619398

PSA3
Proteasome subunit alpha type-3

2

20

Small-scale

0.584

High

625964

PSB2
Proteasome subunit beta type-2

2

20

Small-scale

0.584

High

632509

PSB3
Proteasome subunit beta type-3

2

20

Small-scale

0.584

High

636780

CDC48
Cell division control protein 48

2

2

Small-scale

0.584

High

675493

PSB7
Proteasome subunit beta type-7

2

20

Small-scale

0.584

High

689218

PSA5
Proteasome subunit alpha type-5

2

19

Small-scale

0.584

High

775501

PSMD9
Probable 26S proteasome regulatory subunit p27

2

3

Small-scale

0.584

High

865892

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

5

Small-scale

0.584

High

367084

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

495302

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

578579

SEC18
Vesicular-fusion protein SEC18

2

4

High-throughput

0.549

High

861494

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.536

High

977146

ESC1
Silent chromatin protein ESC1

2

1

High-throughput

0.533

High

812291

JSN1
Protein JSN1

1

0

High-throughput

0.518

High

715629

SQT1
Ribosome assembly protein SQT1

1

3

High-throughput

0.515

High

965074

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.515

High

1015305

TIP41
Type 2A phosphatase activator TIP41

1

1

High-throughput

0.515

High

1015370

IQG1
Ras GTPase-activating-like protein IQG1

1

1

High-throughput

0.515

High

604287

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.513

High

693636

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

5

Small-scale

0.508

High

410469

SC160
Protein SCP160

1

0

High-throughput

0.493

High

710482

TOD6
Transcriptional regulatory protein TOD6

1

0

High-throughput

0.493

High

756404

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.493

High

605599

DBF2
Cell cycle protein kinase DBF2

1

1

High-throughput

0.489

High

748402

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.489

High

978099

SPC19
DASH complex subunit SPC19

1

0

High-throughput

0.486

High

389341

HXKA
Hexokinase-1

1

0

High-throughput

0.479

High

407396

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

523326

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

4

Small-scale

0.479

High

524485

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

544599

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

632149

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

681084

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

692096

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

697126

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

728341

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

765182

PAC2
Protein PAC2

1

4

Small-scale

0.479

High

765492

LIS1
Nuclear distribution protein PAC1

1

5

Small-scale

0.479

High

797335

BLM10
Proteasome activator BLM10

1

2

Small-scale

0.479

High

859307

HUL5
E3 ubiquitin-protein ligase HUL5

1

7

Small-scale

0.479

High

866557

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

976421

RPN4
Protein RPN4

1

1

Small-scale

0.479

High

1014846

CDC53
Cell division control protein 53

1

20

High-throughput

0.479

High

630053

BPH1
Beige protein homolog 1

1

6

High-throughput

0.470

High

679879

FUN30
ATP-dependent helicase FUN30

1

2

High-throughput

0.470

High

710099

TFC3
Transcription factor tau 138 kDa subunit

1

1

High-throughput

0.470

High

763797

ERV46
ER-derived vesicles protein ERV46

1

1

High-throughput

0.470

High

482515

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

734325

JNM1
Nuclear migration protein JNM1

1

0

Small-scale

0.458

High

747941

UMP1
Proteasome maturation factor UMP1

1

0

Small-scale

0.458

High

767846

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

Small-scale

0.458

High

811721

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.458

High

974325

ESP1
Separin

1

0

High-throughput

0.458

High

987090

ESC2
Protein ESC2

1

0

Small-scale

0.458

High

995501

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.458

High

996045

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

477489

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

16

High-throughput

0.457

High

423931

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

424766

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

478613

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

492838

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

513201

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

695802

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

705807

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

769798

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

675792

RENT1
ATP-dependent helicase NAM7

1

0

High-throughput

0.438

High

566243

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.437

High

606784

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

628591

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

636239

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.437

High

663669

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

772396

VPS27
Vacuolar protein sorting-associated protein 27

1

1

Small-scale

0.437

High

792631

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

822957

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

859289

INO80
Chromatin-remodeling ATPase INO80

1

2

Small-scale

0.437

High

978378

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

987070

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

1015371

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

541823

SEC63
Protein translocation protein SEC63

1

1

High-throughput

0.407

High

645161

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.407

High

761348

CAJ1
Protein CAJ1

1

3

High-throughput

0.407

High

758398

SNF11
Transcription regulatory protein SNF11

1

0

Small-scale

0.282

High

596676

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

691164

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

High-throughput

0.279

Low

698472

EMP24
Endosomal protein P24B

1

0

High-throughput

0.279

Low

698581

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

High-throughput

0.269

Low

763276

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.269

Low

809528

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.269

Low

862346

SULX
Putative sulfate transporter YPR003C

1

0

High-throughput

0.269

Low

992465

VPS13
Intermembrane lipid transfer protein VPS13

1

0

High-throughput

0.269

Low

1015373

PST1
Cell wall mannoprotein PST1

1

0

High-throughput

0.269

Low

1015378

HTL1
High temperature lethal protein 1

1

0

High-throughput

0.269

Low

634827

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

774016

MLP2
Protein MLP2

1

0

High-throughput

0.249

Low

997002

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

1015377

SLO1
SCOCO-like protein 1

1

0

High-throughput

0.249

Low

983800

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.238

Low

383411

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

406078

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.232

Low

413770

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.232

Low

810309

RL17B
Large ribosomal subunit protein uL22B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024