Protein: MKAR
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (3-ketoacyl-CoA reductase) (3-ketoreductase) (KAR) (Microsomal beta-keto-reductase)

Gene: MKAR, IFA38
Organism: Saccharomyces cerevisiae S288C
Interactions: 174
UniProt ID: P38286

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0030148 - sphingolipid biosynthetic process
GO:0030497 - fatty acid elongation
GO:0042761 - very long-chain fatty acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

701403

SC61A
Protein transport protein SEC61

2

3

High-throughput

0.614

High

747776

SSH1
Sec sixty-one protein homolog

2

3

High-throughput

0.614

High

679900

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

2

1

High-throughput

0.601

High

691738

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

1

Small-scale

0.560

High

691786

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

Small-scale

0.560

High

389533

CAN1
Arginine permease CAN1

1

7

High-throughput

0.541

High

419422

HIP1
Histidine permease

1

7

High-throughput

0.541

High

572089

CPT1
Cholinephosphotransferase 1

1

1

High-throughput

0.541

High

580817

GAP1
General amino-acid permease GAP1

1

7

High-throughput

0.541

High

604731

EPT1
Choline/ethanolaminephosphotransferase 1

1

1

High-throughput

0.541

High

628703

PHO84
Inorganic phosphate transporter PHO84

1

3

High-throughput

0.541

High

630596

ADP1
Probable ATP-dependent permease

1

2

High-throughput

0.541

High

630719

AGP1
General amino acid permease AGP1

1

7

High-throughput

0.541

High

659152

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.541

High

688594

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

2

High-throughput

0.541

High

689081

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.541

High

698402

EMP24
Endosomal protein P24B

1

7

High-throughput

0.541

High

704750

SGE1
Protein SGE1

1

8

High-throughput

0.541

High

707413

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

1

High-throughput

0.541

High

731901

MCD4
GPI ethanolamine phosphate transferase 1

1

1

High-throughput

0.541

High

747778

VBA2
Vacuolar basic amino acid transporter 2

1

9

High-throughput

0.541

High

747783

ERP5
Protein ERP5

1

5

High-throughput

0.541

High

747787

SUR2
Sphingolipid C4-hydroxylase SUR2

1

2

High-throughput

0.541

High

747790

ELO1
Fatty acid elongase 1

1

5

High-throughput

0.541

High

747801

EPS1
ER-retained PMA1-suppressing protein 1

1

2

High-throughput

0.541

High

747807

BAP3
Valine amino-acid permease

1

7

High-throughput

0.541

High

747809

EMP47
Protein EMP47

1

1

High-throughput

0.541

High

747817

GNP1
High-affinity glutamine permease

1

7

High-throughput

0.541

High

747824

YIP1
Protein transport protein YIP1

1

1

High-throughput

0.541

High

747825

ERG25
C-4 methylsterol oxidase ERG25

1

2

High-throughput

0.541

High

747836

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

1

High-throughput

0.541

High

747849

ERV41
ER-derived vesicles protein ERV41

1

2

High-throughput

0.541

High

747857

PMT7
Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

1

1

High-throughput

0.541

High

747860

THI73
Thiamine pathway transporter THI73

1

4

High-throughput

0.541

High

747865

SAM3
S-adenosylmethionine permease SAM3

1

7

High-throughput

0.541

High

747868

MMP1
S-methylmethionine permease 1

1

7

High-throughput

0.541

High

747869

EMP46
Protein EMP46

1

3

High-throughput

0.541

High

747871

TECR
Very-long-chain enoyl-CoA reductase

1

3

High-throughput

0.541

High

446987

EI2BG
Translation initiation factor eIF2B subunit gamma

2

1

Small-scale

0.521

High

521188

EI2BD
Translation initiation factor eIF2B subunit delta

2

2

Small-scale

0.521

High

539976

EI2BA
Translation initiation factor eIF2B subunit alpha

2

2

Small-scale

0.521

High

520255

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.518

High

547996

SEC11
Signal peptidase complex catalytic subunit SEC11

1

0

High-throughput

0.518

High

556547

ERD1
Protein ERD1

1

0

High-throughput

0.518

High

561974

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.518

High

596972

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.518

High

716143

CSG2
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

1

0

High-throughput

0.518

High

743851

YRO2
Protein YRO2

1

0

High-throughput

0.518

High

747775

YPC1
Alkaline ceramidase YPC1

1

0

High-throughput

0.518

High

747777

BSD2
Metal homeostatis protein BSD2

1

0

High-throughput

0.518

High

747784

NSG1
Protein NSG1

1

0

High-throughput

0.518

High

747785

YHU0
UPF0641 membrane protein YHR140W

1

0

High-throughput

0.518

High

747786

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.518

High

747788

FET3
Iron transport multicopper oxidase FET3

1

0

High-throughput

0.518

High

747793

SEC72
Translocation protein SEC72

1

0

High-throughput

0.518

High

747811

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

747812

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.518

High

747814

YJY5
Uncharacterized endoplasmic reticulum membrane protein YJR015W

1

0

High-throughput

0.518

High

747818

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

747829

SULX
Putative sulfate transporter YPR003C

1

0

High-throughput

0.518

High

747831

ARE2
Sterol O-acyltransferase 2

1

0

High-throughput

0.518

High

747841

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.518

High

747850

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.518

High

747854

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.518

High

747863

GUP2
Membrane-bound O-acyltransferase GUP2

1

0

High-throughput

0.518

High

747867

POM33
Pore membrane protein of 33 kDa

1

0

High-throughput

0.518

High

493812

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.504

High

511106

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.504

High

621165

FPS1
Glycerol uptake/efflux facilitator protein

1

4

High-throughput

0.494

High

699026

UGA4
GABA-specific permease

1

8

High-throughput

0.494

High

700233

PMP1
Plasma membrane ATPase proteolipid 1

1

1

High-throughput

0.494

High

732067

AVT3
Vacuolar amino acid transporter 3

1

2

High-throughput

0.494

High

734169

GEX2
Glutathione exchanger 2

1

10

High-throughput

0.494

High

745060

MAL31
Maltose permease MAL31

1

3

High-throughput

0.494

High

747781

COS8
Protein COS8

1

7

High-throughput

0.494

High

747782

YHE2
Putative uncharacterized protein YHL042W

1

5

High-throughput

0.494

High

747791

UIP3
ULP1-interacting protein 3

1

7

High-throughput

0.494

High

747792

KTD1
Protein-toxin resistance protein KTD1

1

7

High-throughput

0.494

High

747798

QDR1
Quinidine resistance protein 1

1

6

High-throughput

0.494

High

747803

HXT9
Hexose transporter HXT9

1

2

High-throughput

0.494

High

747804

HXT8
Hexose transporter HXT8

1

2

High-throughput

0.494

High

747806

PMP2
Plasma membrane ATPase proteolipid 2

1

1

High-throughput

0.494

High

747808

COS4
Protein COS4

1

7

High-throughput

0.494

High

747816

COS5
Protein COS5

1

7

High-throughput

0.494

High

747823

AVT4
Vacuolar amino acid transporter 4

1

2

High-throughput

0.494

High

747826

VPS73
Vacuolar protein sorting-associated protein 73

1

5

High-throughput

0.494

High

747827

TNA1
High-affinity nicotinic acid transporter

1

4

High-throughput

0.494

High

747828

COS6
Protein COS6

1

7

High-throughput

0.494

High

747833

PDR18
ABC transporter ATP-binding protein/permease PDR18

1

1

High-throughput

0.494

High

747837

HXT11
Hexose transporter HXT11

1

2

High-throughput

0.494

High

747843

YM8M
Uncharacterized transporter YMR279C

1

9

High-throughput

0.494

High

747845

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

1

High-throughput

0.494

High

747853

TPO3
Polyamine transporter 3

1

6

High-throughput

0.494

High

747859

TPO1
Polyamine transporter 1

1

6

High-throughput

0.494

High

747861

GAS4
1,3-beta-glucanosyltransferase GAS4

1

1

High-throughput

0.494

High

491041

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.489

High

747839

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.489

High

747797

ELO3
Fatty acid elongase 3

1

5

High-throughput

0.479

High

389901

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.470

High

393562

PMA1
Plasma membrane ATPase 1

1

1

High-throughput

0.470

High

690189

CDC3
Cell division control protein 3

1

2

High-throughput

0.470

High

747815

ARP3
Actin-related protein 3

1

2

High-throughput

0.470

High

747847

HMO1
High mobility group protein 1

1

1

High-throughput

0.470

High

747852

CORO
Coronin-like protein

1

2

High-throughput

0.470

High

635195

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

707191

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

747305

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

747800

SNL1
HSP70 co-chaperone SNL1

1

0

High-throughput

0.458

High

747802

HACD
Very-long-chain

1

0

Small-scale

0.458

High

747851

SVF1
Ceramide-binding protein SVF1

1

0

High-throughput

0.458

High

478779

COS3
Protein COS3

1

7

High-throughput

0.439

High

627976

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

745626

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

747810

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.437

High

747830

COPA
Coatomer subunit alpha

1

6

High-throughput

0.437

High

747835

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

743510

HMT1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.417

High

420120

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.407

High

450028

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.407

High

502988

SEC7
Protein transport protein SEC7

1

2

High-throughput

0.407

High

633180

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

690874

HIR2
Protein HIR2

1

3

High-throughput

0.407

High

690915

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.407

High

747794

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.407

High

747796

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.407

High

747822

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.407

High

747813

MTC1
Maintenance of telomere capping protein 1

2

0

High-throughput

0.313

High

621406

VATO
V-type proton ATPase subunit c''

1

0

High-throughput

0.282

High

648977

PHO91
Low-affinity phosphate transporter PHO91

1

0

High-throughput

0.282

High

679882

FUN26
Nucleoside transporter FUN26

1

0

High-throughput

0.282

High

698367

TMN1
Transmembrane 9 superfamily member 1

1

0

High-throughput

0.282

High

747805

VTH2
VPS10 homolog 2

1

0

High-throughput

0.282

High

747820

CTR1
Copper transport protein CTR1

1

0

High-throughput

0.282

High

747834

PRM1
Plasma membrane fusion protein PRM1

1

0

High-throughput

0.282

High

747844

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

0

High-throughput

0.282

High

747855

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.282

High

747856

ARR3
Arsenical-resistance protein 3

1

0

High-throughput

0.282

High

747858

MCH1
Probable transporter MCH1

1

0

High-throughput

0.282

High

747864

YP264
Probable transport protein YPL264C

1

0

High-throughput

0.282

High

747870

YD206
Putative cation exchanger YDL206W

1

0

High-throughput

0.282

High

710593

YEL1
Guanine-nucleotide exchange factor YEL1

1

0

High-throughput

0.269

Low

747799

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

0

High-throughput

0.269

Low

747832

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.269

Low

747840

KIN4
Serine/threonine-protein kinase KIN4

1

0

High-throughput

0.269

Low

747842

COFI
Cofilin

1

0

High-throughput

0.269

Low

747866

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.269

Low

747780

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.261

Low

711104

YKK0
Probable intramembrane protease YKL100C

1

0

High-throughput

0.249

Low

747789

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

747795

IMB4
Importin subunit beta-4

1

0

High-throughput

0.249

Low

747819

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

747838

H3
Histone H3

1

0

High-throughput

0.249

Low

747848

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

747862

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

145723

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.232

Low

356437

H4
Histone H4

1

0

High-throughput

0.232

Low

358034

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.232

Low

368000

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low

383106

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.232

Low

399440

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

404558

RL7A
Large ribosomal subunit protein uL30A

1

0

High-throughput

0.232

Low

405985

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.232

Low

519514

PDR1
Transcription factor PDR1

1

0

High-throughput

0.232

Low

534750

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

534964

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.232

Low

556004

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

613684

RS3A2
Small ribosomal subunit protein eS1B

1

0

High-throughput

0.232

Low

640924

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

645407

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.232

Low

696137

SWI3
SWI/SNF complex subunit SWI3

1

0

High-throughput

0.232

Low

696204

STH1
Nuclear protein STH1/NPS1

1

0

High-throughput

0.232

Low

747779

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low

747821

RL4B
Large ribosomal subunit protein uL4B

1

0

High-throughput

0.232

Low

747846

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024