Protein: JAK2
Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2)

Gene: JAK2
Organism: Homo sapiens
Interactions: 137
UniProt ID: O60674

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0001774 - microglial cell activation
GO:0002250 - adaptive immune response
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181748

SOCS1
Suppressor of cytokine signaling 1

16

20

Small-scale

0.984

High

147366

SOCS3
Suppressor of cytokine signaling 3

12

20

Small-scale

0.979

High

238377

STAT3
Signal transducer and activator of transcription 3

11

20

Small-scale

0.972

High

238318

JAK2
Tyrosine-protein kinase JAK2

9

19

Small-scale

0.969

High

238440

SH2B1
SH2B adapter protein 1

5

20

Small-scale

0.934

High

238351

PTN1
Tyrosine-protein phosphatase non-receptor type 1

4

20

Small-scale

0.914

High

238323

EGFR
Epidermal growth factor receptor

5

20

Small-scale

0.912

High

238378

STAT1
Signal transducer and activator of transcription 1-alpha/beta

4

20

Small-scale

0.892

High

238401

PTN11
Tyrosine-protein phosphatase non-receptor type 11

4

20

Small-scale

0.890

High

238379

STA5A
Signal transducer and activator of transcription 5A

4

20

Small-scale

0.888

High

238395

GRB2
Growth factor receptor-bound protein 2

4

20

Small-scale

0.882

High

238338

GHR
Growth hormone receptor

4

20

Small-scale

0.873

High

238353

EPOR
Erythropoietin receptor

3

20

Small-scale

0.861

High

238360

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

20

Small-scale

0.861

High

238387

STA5B
Signal transducer and activator of transcription 5B

3

20

Small-scale

0.835

High

238369

IRS1
Insulin receptor substrate 1

3

20

Small-scale

0.834

High

238345

VAV
Proto-oncogene vav

2

20

Small-scale

0.806

High

238435

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.785

High

238363

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.778

High

238362

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

20

Small-scale

0.776

High

238357

JAK1
Tyrosine-protein kinase JAK1

2

19

Small-scale

0.768

High

238380

TEC
Tyrosine-protein kinase Tec

2

20

Small-scale

0.768

High

145961

SH2B2
SH2B adapter protein 2

2

20

Small-scale

0.755

High

238329

INSR
Insulin receptor

2

20

Small-scale

0.754

High

238352

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

20

Small-scale

0.754

High

238400

FAK1
Focal adhesion kinase 1

2

20

Small-scale

0.754

High

238330

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.724

High

238425

STAM1
Signal transducing adapter molecule 1

1

20

Small-scale

0.724

High

238434

I12R2
Interleukin-12 receptor subunit beta-2

1

20

Small-scale

0.724

High

238368

IL3RB
Cytokine receptor common subunit beta

5

20

Small-scale

0.711

High

238342

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.691

High

238431

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

5

High-throughput

0.691

High

238388

JAK3
Tyrosine-protein kinase JAK3

1

19

Small-scale

0.665

High

238327

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.647

High

238332

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.647

High

238355

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

238402

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.647

High

153506

ANM5
Protein arginine N-methyltransferase 5

2

12

Small-scale

0.644

High

238354

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

20

Small-scale

0.634

High

238442

UBIP1
Upstream-binding protein 1

2

3

High-throughput

0.628

High

238319

ROCK2
Rho-associated protein kinase 2

1

20

Small-scale

0.618

High

238321

STAM2
Signal transducing adapter molecule 2

1

20

Small-scale

0.618

High

238328

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

238333

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.618

High

238337

KIT
Mast/stem cell growth factor receptor Kit

1

20

Small-scale

0.618

High

238341

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.618

High

238346

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

238350

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

20

Small-scale

0.618

High

238364

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

238374

IL6RB
Interleukin-6 receptor subunit beta

1

20

Small-scale

0.618

High

238392

1433G
14-3-3 protein gamma

1

20

High-throughput

0.618

High

238393

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.618

High

238399

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

Small-scale

0.618

High

238405

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.618

High

238408

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

238424

SOCS4
Suppressor of cytokine signaling 4

1

20

Small-scale

0.618

High

238433

ASB2
Ankyrin repeat and SOCS box protein 2

1

18

Small-scale

0.618

High

238445

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.618

High

238446

SH2B3
SH2B adapter protein 3

1

20

Small-scale

0.618

High

238367

IL2RG
Cytokine receptor common subunit gamma

2

20

Small-scale

0.601

High

238398

IL5RA
Interleukin-5 receptor subunit alpha

1

20

Small-scale

0.586

High

238344

INGR1
Interferon gamma receptor 1

2

18

Small-scale

0.584

High

238348

PRLR
Prolactin receptor

2

20

Small-scale

0.584

High

238375

TPOR
Thrombopoietin receptor

2

7

Small-scale

0.584

High

238356

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.578

High

238381

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

7

Small-scale

0.578

High

238448

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.561

High

238376

VHL
von Hippel-Lindau disease tumor suppressor

2

0

Small-scale

0.559

High

238371

RBMX
RNA-binding motif protein, X chromosome

1

11

High-throughput

0.541

High

238426

ARL11
ADP-ribosylation factor-like protein 11

1

12

High-throughput

0.541

High

157158

BACH1
Transcription regulator protein BACH1

1

5

High-throughput

0.536

High

238320

HMMR
Hyaluronan mediated motility receptor

1

20

High-throughput

0.536

High

238340

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

238383

EMD
Emerin

1

3

High-throughput

0.536

High

238390

NP1L1
Nucleosome assembly protein 1-like 1

1

7

High-throughput

0.536

High

238410

IMB1
Importin subunit beta-1

1

10

High-throughput

0.536

High

238420

RHG18
Rho GTPase-activating protein 18

1

20

High-throughput

0.536

High

238421

MUC7
Mucin-7

1

18

High-throughput

0.536

High

238439

MUC5B
Mucin-5B

1

20

High-throughput

0.536

High

238443

SPRR3
Small proline-rich protein 3

1

2

High-throughput

0.536

High

238441

CISH
Cytokine-inducible SH2-containing protein

1

20

Small-scale

0.527

High

238324

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.518

High

238432

HSFY1
Heat shock transcription factor, Y-linked

1

0

High-throughput

0.518

High

238358

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.515

High

238372

BRCA1
Breast cancer type 1 susceptibility protein

1

13

Small-scale

0.515

High

238391

CXCR4
C-X-C chemokine receptor type 4

1

16

Small-scale

0.515

High

238430

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

13

Small-scale

0.515

High

238325

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.513

High

238335

CYTT
Cystatin-SA

1

0

High-throughput

0.513

High

238428

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

238370

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

Small-scale

0.508

High

238373

INGR2
Interferon gamma receptor 2

1

20

Small-scale

0.501

High

238384

TUB
Tubby protein homolog

1

7

Small-scale

0.501

High

238389

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.501

High

238397

GTF2I
General transcription factor II-I

1

2

Small-scale

0.501

High

238413

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

Small-scale

0.501

High

238414

H31T
Histone H3.1t

1

4

Small-scale

0.501

High

238412

RCN1
Reticulocalbin-1

1

3

High-throughput

0.489

High

238429

BPIA2
BPI fold-containing family A member 2

1

1

High-throughput

0.489

High

238447

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.481

High

238322

LDOC1
Protein LDOC1

1

1

Small-scale

0.479

High

238331

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.479

High

238334

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.479

High

238339

HSP7C
Heat shock cognate 71 kDa protein

1

20

Small-scale

0.479

High

238343

IL2RB
Interleukin-2 receptor subunit beta

1

20

Small-scale

0.479

High

238347

CTLA4
Cytotoxic T-lymphocyte protein 4

1

4

Small-scale

0.479

High

238349

TSHR
Thyrotropin receptor

1

20

Small-scale

0.479

High

238359

PTAFR
Platelet-activating factor receptor

1

20

Small-scale

0.479

High

238361

5HT2A
5-hydroxytryptamine receptor 2A

1

10

Small-scale

0.479

High

238365

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

9

Small-scale

0.479

High

238366

AGTR1
Type-1 angiotensin II receptor

1

16

Small-scale

0.479

High

238386

CCR5
C-C chemokine receptor type 5

1

17

Small-scale

0.479

High

238394

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

7

Small-scale

0.479

High

238396

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

10

Small-scale

0.479

High

238403

G3BP1
Ras GTPase-activating protein-binding protein 1

1

11

Small-scale

0.479

High

238404

SKP2
S-phase kinase-associated protein 2

1

14

Small-scale

0.479

High

238406

CUL4A
Cullin-4A

1

11

High-throughput

0.479

High

238407

CUL4B
Cullin-4B

1

11

High-throughput

0.479

High

238409

HES1
Transcription factor HES-1

1

2

Small-scale

0.479

High

238411

JOS1
Josephin-1

1

1

Small-scale

0.479

High

238415

HES5
Transcription factor HES-5

1

2

Small-scale

0.479

High

238416

RN123
E3 ubiquitin-protein ligase RNF123

1

9

High-throughput

0.479

High

238417

ELP2
Elongator complex protein 2

1

10

Small-scale

0.479

High

238418

H32
Histone H3.2

1

4

Small-scale

0.479

High

238419

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

8

Small-scale

0.479

High

238422

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.479

High

238423

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

8

Small-scale

0.479

High

238427

OPTN
Optineurin

1

20

Small-scale

0.479

High

238436

STRA6
Receptor for retinol uptake STRA6

1

1

Small-scale

0.479

High

238438

CLSPN
Claspin

1

5

High-throughput

0.479

High

238444

HDAC6
Histone deacetylase 6

1

8

Small-scale

0.479

High

238385

RASF2
Ras association domain-containing protein 2

1

0

High-throughput

0.458

High

238437

GOLP3
Golgi phosphoprotein 3

1

0

Small-scale

0.458

High

238326

IGHA2
Immunoglobulin heavy constant alpha 2

1

14

High-throughput

0.445

High

238382

LEPR
Leptin receptor

1

20

Small-scale

0.445

High

238336

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024