Protein: ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Gene: ERN1
Organism: Homo sapiens
Interactions: 92
UniProt ID: O75460

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001935 - endothelial cell proliferation
GO:0004521 - RNA endonuclease activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005161 - platelet-derived growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

265486

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

4

18

Small-scale

0.931

High

265554

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

17

Small-scale

0.754

High

265510

SRPK2
SRSF protein kinase 2

1

15

High-throughput

0.735

High

265495

HS90A
Heat shock protein HSP 90-alpha

1

19

Small-scale

0.724

High

265498

BIP
Endoplasmic reticulum chaperone BiP

5

11

Small-scale

0.711

High

265534

SYVN1
E3 ubiquitin-protein ligase synoviolin

4

3

Small-scale

0.691

High

265559

TAOK3
Serine/threonine-protein kinase TAO3

1

12

Small-scale

0.683

High

265515

TRAF2
TNF receptor-associated factor 2

4

9

Small-scale

0.683

High

265548

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.665

High

265543

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

3

High-throughput

0.628

High

265507

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

1

Small-scale

0.620

High

265546

CSN5
COP9 signalosome complex subunit 5

2

3

Small-scale

0.620

High

201731

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

1

Small-scale

0.618

High

226058

PRKN
E3 ubiquitin-protein ligase parkin

1

12

Small-scale

0.618

High

265497

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

Small-scale

0.618

High

265519

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

4

Small-scale

0.618

High

265502

CDN1A
Cyclin-dependent kinase inhibitor 1

1

5

High-throughput

0.594

High

265512

GABP1
GA-binding protein subunit beta-1

1

2

High-throughput

0.594

High

265524

ZN829
Zinc finger protein 829

1

2

High-throughput

0.594

High

265558

ZN341
Zinc finger protein 341

1

1

High-throughput

0.594

High

265564

SE1L1
Protein sel-1 homolog 1

2

2

Small-scale

0.594

High

265508

SC61B
Protein transport protein Sec61 subunit beta

2

0

Small-scale

0.585

High

265568

CHIP
E3 ubiquitin-protein ligase CHIP

1

6

Small-scale

0.578

High

265565

SEC63
Translocation protein SEC63 homolog

1

2

Small-scale

0.575

High

265551

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

2

High-throughput

0.574

High

265494

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.561

High

265528

PKHS1
Pleckstrin homology domain-containing family S member 1

1

0

High-throughput

0.556

High

265561

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.537

High

265540

TAFA2
Chemokine-like protein TAFA-2

1

1

High-throughput

0.536

High

265516

NMI
N-myc-interactor

1

0

Small-scale

0.529

High

147463

SOCS6
Suppressor of cytokine signaling 6

1

17

High-throughput

0.515

High

182304

PER1
Period circadian protein homolog 1

1

1

High-throughput

0.515

High

265503

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.515

High

265526

PKHG4
Puratrophin-1

1

7

High-throughput

0.515

High

265531

OTU7B
OTU domain-containing protein 7B

1

4

High-throughput

0.515

High

265536

TMTC1
Protein O-mannosyl-transferase TMTC1

1

4

High-throughput

0.515

High

265545

DPF1
Zinc finger protein neuro-d4

1

1

High-throughput

0.515

High

265552

KAD8
Adenylate kinase 8

1

3

High-throughput

0.515

High

265560

CD209
CD209 antigen

1

1

High-throughput

0.515

High

265511

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

0

High-throughput

0.513

High

265522

ADIPO
Adiponectin

1

0

High-throughput

0.513

High

265527

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

265513

BAX
Apoptosis regulator BAX

1

1

Small-scale

0.501

High

265487

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

265514

INCA1
Protein INCA1

1

0

High-throughput

0.493

High

265555

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.493

High

265491

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.489

High

265499

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.489

High

265501

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

4

High-throughput

0.489

High

265523

CL12B
C-type lectin domain family 12 member B

1

1

High-throughput

0.489

High

265518

OS9
Protein OS-9

1

0

Small-scale

0.479

High

265547

YIPF5
Protein YIPF5

1

0

Small-scale

0.479

High

206709

B2L11
Bcl-2-like protein 11

1

1

Small-scale

0.479

High

207528

RNF13
E3 ubiquitin-protein ligase RNF13

1

3

Small-scale

0.479

High

265493

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

265496

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

5

Small-scale

0.479

High

265500

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

17

Small-scale

0.479

High

265521

PDIA6
Protein disulfide-isomerase A6

1

6

High-throughput

0.479

High

265535

FBX11
F-box only protein 11

1

1

Small-scale

0.479

High

265553

DERL3
Derlin-3

1

1

Small-scale

0.479

High

265557

DERL1
Derlin-1

1

1

Small-scale

0.479

High

265569

TRAF6
TNF receptor-associated factor 6

1

13

Small-scale

0.479

High

265532

Q6PHZ7
NR2C2 protein

1

6

High-throughput

0.470

High

265539

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

1

High-throughput

0.470

High

265563

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

5

High-throughput

0.470

High

265566

LAT2
Large neutral amino acids transporter small subunit 2

1

4

High-throughput

0.470

High

265504

PSN1
Presenilin-1

1

0

Small-scale

0.458

High

265488

SC24D
Protein transport protein Sec24D

1

3

Small-scale

0.445

High

265489

SC24A
Protein transport protein Sec24A

1

3

Small-scale

0.445

High

265490

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.445

High

265506

SC24C
Protein transport protein Sec24C

1

3

Small-scale

0.445

High

265509

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

Small-scale

0.445

High

265556

CNPY3
Protein canopy homolog 3

1

1

Small-scale

0.437

High

265537

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.426

High

265549

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.324

High

265492

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.279

Low

265517

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

265533

LYPD4
Ly6/PLAUR domain-containing protein 4

1

0

High-throughput

0.279

Low

265538

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

265541

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

265570

PCDGH
Protocadherin gamma-B5

1

0

High-throughput

0.279

Low

265505

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.268

Low

265520

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.268

Low

265525

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

265529

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.268

Low

265530

ADAL
Adenosine deaminase-like protein

1

0

High-throughput

0.268

Low

265542

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

0

High-throughput

0.268

Low

265544

LAR4B
La-related protein 4B

1

0

High-throughput

0.268

Low

265562

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

265550

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.249

Low

265567

FXL21
Putative F-box/LRR-repeat protein 21

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024