Protein: SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)

Gene: SIR5, SIRT5
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9NXA8

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

447301

HXB5
Homeobox protein Hox-B5

3

9

High-throughput

0.667

High

1347878

CWC15
Spliceosome-associated protein CWC15 homolog

3

1

High-throughput

0.667

High

300839

GLSK
Glutaminase kidney isoform, mitochondrial

3

2

Small-scale

0.640

High

885911

YBEY
Endoribonuclease YbeY

2

1

High-throughput

0.628

High

1218466

WDFY1
WD repeat and FYVE domain-containing protein 1

2

4

High-throughput

0.628

High

1345678

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

11

Small-scale

0.618

High

180647

GLYG2
Glycogenin-2

2

0

High-throughput

0.602

High

1132630

THEM4
Acyl-coenzyme A thioesterase THEM4

2

0

High-throughput

0.602

High

1261371

CPLX3
Complexin-3

2

0

High-throughput

0.602

High

585082

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

Small-scale

0.578

High

1273923

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

13

Small-scale

0.561

High

398409

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.536

High

509990

VDR
Vitamin D3 receptor

1

18

High-throughput

0.536

High

513903

DMD
Dystrophin

1

9

High-throughput

0.536

High

568231

TAL1
T-cell acute lymphocytic leukemia protein 1

1

5

High-throughput

0.536

High

595643

HXA5
Homeobox protein Hox-A5

1

8

High-throughput

0.536

High

803777

BAG6
Large proline-rich protein BAG6

1

7

High-throughput

0.536

High

856127

RBM5
RNA-binding protein 5

1

8

High-throughput

0.536

High

959717

VIGLN
Vigilin

1

6

High-throughput

0.536

High

960061

HXC5
Homeobox protein Hox-C5

1

9

High-throughput

0.536

High

1048254

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

5

High-throughput

0.536

High

1148013

ZN776
Zinc finger protein 776

1

2

High-throughput

0.536

High

1252674

ZSC18
Zinc finger and SCAN domain-containing protein 18

1

2

High-throughput

0.536

High

1289713

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1298623

ZMAT2
Zinc finger matrin-type protein 2

1

2

High-throughput

0.536

High

1327870

PAR12
Protein mono-ADP-ribosyltransferase PARP12

1

2

High-throughput

0.536

High

778312

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.515

High

1221266

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1304346

SORT
Sortilin

1

0

High-throughput

0.513

High

395912

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1222728

CKP2L
Cytoskeleton-associated protein 2-like

1

0

High-throughput

0.493

High

958875

HXA4
Homeobox protein Hox-A4

1

8

High-throughput

0.489

High

1191336

SNX20
Sorting nexin-20

1

6

High-throughput

0.489

High

1290172

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

1347879

PCD10
Protocadherin-10

1

1

High-throughput

0.489

High

245018

BRD4
Bromodomain-containing protein 4

1

13

Small-scale

0.479

High

263004

CISY
Citrate synthase, mitochondrial

1

6

Small-scale

0.479

High

348054

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.479

High

617380

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.479

High

713638

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

Small-scale

0.479

High

780205

CCNF
Cyclin-F

1

4

Small-scale

0.479

High

813789

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

822519

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

Small-scale

0.479

High

873491

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

9

Small-scale

0.479

High

978915

TF65
Transcription factor p65

1

7

Small-scale

0.479

High

1171988

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1224236

DOCK3
Dedicator of cytokinesis protein 3

1

4

High-throughput

0.479

High

1292255

AURKB
Aurora kinase B

1

5

High-throughput

0.479

High

149356

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

1347287

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1347880

HECW2
E3 ubiquitin-protein ligase HECW2

1

6

High-throughput

0.437

High

355117

HBAZ
Hemoglobin subunit zeta

2

0

High-throughput

0.328

High

1126259

RABL3
Rab-like protein 3

2

0

High-throughput

0.328

High

1168210

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1169150

GBP6
Guanylate-binding protein 6

1

0

High-throughput

0.279

Low

1203723

CDR2L
Cerebellar degeneration-related protein 2-like

1

0

High-throughput

0.279

Low

1330323

SEM4A
Semaphorin-4A

1

0

High-throughput

0.279

Low

1347881

GHRL
Appetite-regulating hormone

1

0

High-throughput

0.279

Low

282785

SYUG
Gamma-synuclein

1

0

High-throughput

0.269

Low

352280

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1347882

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024