Protein: POLH
DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)

Gene: POLH
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9Y253

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003684 - damaged DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

517546

PCNA
Proliferating cell nuclear antigen

20

14

Small-scale

0.988

High

1354475

REV1
DNA repair protein REV1

8

13

Small-scale

0.973

High

1357463

POLI
DNA polymerase iota

2

12

Small-scale

0.828

High

1345463

RAD18
E3 ubiquitin-protein ligase RAD18

7

2

Small-scale

0.743

High

476588

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

9

Small-scale

0.734

High

1151405

Q6FI35
Proliferating cell nuclear antigen

1

14

Small-scale

0.637

High

1273977

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

1

Small-scale

0.634

High

892122

ACTB
Actin, cytoplasmic 1

2

2

High-throughput

0.628

High

1377025

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

0

High-throughput

0.602

High

1377024

POLH
DNA polymerase eta

1

13

Small-scale

0.590

High

1299493

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

Small-scale

0.585

High

474860

POTEI
POTE ankyrin domain family member I

2

1

High-throughput

0.574

High

1122538

ACTBL
Beta-actin-like protein 2

2

1

High-throughput

0.574

High

847931

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.571

High

1205497

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.561

High

1314607

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

3

Small-scale

0.552

High

776430

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.549

High

933670

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.536

High

487856

ANDR
Androgen receptor

1

1

High-throughput

0.534

High

823233

DPOD2
DNA polymerase delta subunit 2

1

1

Small-scale

0.527

High

224862

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.513

High

519107

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

828643

CENPF
Centromere protein F

1

0

High-throughput

0.513

High

999697

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

1019245

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1245352

KNL1
Kinetochore scaffold 1

1

0

High-throughput

0.513

High

1344540

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.513

High

1356559

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

0

High-throughput

0.513

High

396072

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1314939

GTPB2
GTP-binding protein 2

1

1

High-throughput

0.489

High

151261

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

278191

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

Small-scale

0.479

High

432377

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

749969

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.479

High

927787

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.479

High

952710

H33
Histone H3.3

1

4

High-throughput

0.479

High

980916

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1244575

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

1246205

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1254966

SP7
Transcription factor Sp7

1

2

High-throughput

0.479

High

1288396

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

1315406

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.479

High

1315909

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1355739

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

7

Small-scale

0.479

High

1282395

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

233020

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

304399

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

309172

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

391976

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.458

High

428504

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

727614

HNF1B
Hepatocyte nuclear factor 1-beta

1

0

High-throughput

0.458

High

944996

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.458

High

963030

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1038835

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1063310

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

0

Small-scale

0.458

High

1083434

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.458

High

1221847

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1260963

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1285400

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1285992

MOB3A
MOB kinase activator 3A

1

0

High-throughput

0.458

High

1327154

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1356496

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

933393

TBA1B
Tubulin alpha-1B chain

1

2

Small-scale

0.437

High

1079805

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

300509

FRYL
Protein furry homolog-like

1

0

High-throughput

0.279

Low

640035

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.279

Low

1033019

PLD1
Phospholipase D1

1

0

High-throughput

0.279

Low

1315171

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024