Protein: LYAG
Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]

Gene: LYAG, GAA
Organism: Homo sapiens
Interactions: 101
UniProt ID: P10253

Gene Ontology (top 5):
GO:0000023 - maltose metabolic process
GO:0002026 - regulation of the force of heart contraction
GO:0002086 - diaphragm contraction
GO:0003007 - heart morphogenesis
GO:0004558 - alpha-1,4-glucosidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

487022

B4GN3
Beta-1,4-N-acetylgalactosaminyltransferase 3

2

0

High-throughput

0.770

High

487011

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.691

High

486992

B4GT1
Beta-1,4-galactosyltransferase 1

2

1

High-throughput

0.628

High

486995

AMD
Peptidyl-glycine alpha-amidating monooxygenase

2

1

High-throughput

0.628

High

486998

MA2A2
Alpha-mannosidase 2x

2

1

High-throughput

0.628

High

487034

GALT4
Polypeptide N-acetylgalactosaminyltransferase 4

2

1

High-throughput

0.628

High

487054

ENTP7
Ectonucleoside triphosphate diphosphohydrolase 7

2

2

High-throughput

0.628

High

487064

B4GT7
Beta-1,4-galactosyltransferase 7

2

1

High-throughput

0.628

High

295708

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

2

0

High-throughput

0.602

High

487018

T132A
Transmembrane protein 132A

2

0

High-throughput

0.602

High

487015

EXT1
Exostosin-1

2

1

High-throughput

0.574

High

487019

LRC24
Leucine-rich repeat-containing protein 24

2

4

High-throughput

0.574

High

487037

PGLT1
Protein O-glucosyltransferase 1

2

1

High-throughput

0.574

High

487044

CNT3B
Contactin-associated protein-like 3B

2

2

High-throughput

0.552

High

152236

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.536

High

260215

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

2

High-throughput

0.536

High

314810

LARG1
Xylosyl- and glucuronyltransferase LARGE1

1

1

High-throughput

0.536

High

486985

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.536

High

486986

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.536

High

486989

ADT1
ADP/ATP translocase 1

1

1

High-throughput

0.536

High

486996

CALX
Calnexin

1

5

High-throughput

0.536

High

487004

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

2

High-throughput

0.536

High

487005

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

5

High-throughput

0.536

High

487006

MFGM
Lactadherin

1

3

High-throughput

0.536

High

487017

MA2A1
Alpha-mannosidase 2

1

1

High-throughput

0.536

High

487021

METRL
Meteorin-like protein

1

1

High-throughput

0.536

High

487028

GALT7
N-acetylgalactosaminyltransferase 7

1

1

High-throughput

0.536

High

487033

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

1

High-throughput

0.536

High

487039

CHSTE
Carbohydrate sulfotransferase 14

1

1

High-throughput

0.536

High

487043

EXT2
Exostosin-2

1

1

High-throughput

0.536

High

487045

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

3

High-throughput

0.536

High

487047

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

4

High-throughput

0.536

High

487048

CNTP3
Contactin-associated protein-like 3

1

3

High-throughput

0.536

High

487057

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.536

High

487063

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.536

High

487067

FBX2
F-box only protein 2

1

4

High-throughput

0.536

High

487068

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.536

High

487000

STAT2
Signal transducer and activator of transcription 2

1

0

High-throughput

0.518

High

486990

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.515

High

299551

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

0

High-throughput

0.513

High

419140

ITAV
Integrin alpha-V

1

0

High-throughput

0.513

High

486988

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.513

High

486997

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.513

High

487003

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.513

High

487007

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.513

High

487009

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

487012

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.513

High

487013

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.513

High

487014

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.513

High

487016

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.513

High

487050

LMA2L
VIP36-like protein

1

0

High-throughput

0.513

High

487052

SEM6B
Semaphorin-6B

1

0

High-throughput

0.513

High

487053

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.513

High

487062

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.513

High

487070

JAG2
Protein jagged-2

1

0

High-throughput

0.513

High

161007

CLGN
Calmegin

1

5

High-throughput

0.489

High

265747

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.489

High

487023

PLGT2
Protein O-glucosyltransferase 2

1

1

High-throughput

0.489

High

487025

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.489

High

487032

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.489

High

487038

RDH13
Retinol dehydrogenase 13

1

1

High-throughput

0.489

High

487061

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.489

High

487066

METRN
Meteorin

1

1

High-throughput

0.489

High

487071

DJC16
DnaJ homolog subfamily C member 16

1

8

High-throughput

0.489

High

486991

NCF1
Neutrophil cytosol factor 1

1

1

Small-scale

0.481

High

384153

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

486987

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

487024

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

487041

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

487058

FBX6
F-box only protein 6

1

4

High-throughput

0.479

High

487059

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

487065

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

198218

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.460

High

487002

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.460

High

487056

SHLB2
Endophilin-B2

1

0

High-throughput

0.460

High

487001

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

487031

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

382276

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

3

High-throughput

0.445

High

486993

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.439

High

487008

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.439

High

487042

CBP
CREB-binding protein

1

3

Small-scale

0.439

High

385969

P53
Cellular tumor antigen p53

1

1

High-throughput

0.437

High

486994

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

487026

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

487020

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

0

High-throughput

0.328

High

487029

DYR2
Dihydrofolate reductase 2, mitochondrial

2

0

High-throughput

0.328

High

487035

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

305295

NXPH4
Neurexophilin-4

1

0

High-throughput

0.279

Low

486999

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

487030

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.279

Low

487036

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

487046

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.279

Low

487051

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.279

Low

487060

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.279

Low

487069

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.279

Low

487027

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

0

Small-scale

0.251

Low

487040

PAR3L
Partitioning defective 3 homolog B

1

0

High-throughput

0.251

Low

487072

NUMBL
Numb-like protein

1

0

High-throughput

0.251

Low

487010

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

487049

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

487055

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024