Protein: NPRL2
GATOR1 complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)

Gene: NPRL2
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q8WTW4

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0005774 - vacuolar membrane
GO:0010508 - positive regulation of autophagy
GO:0032007 - negative regulation of TOR signaling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

254989

DEPD5
GATOR1 complex protein DEPDC5

8

2

Small-scale

0.970

High

1021873

NPRL3
GATOR1 complex protein NPRL3

7

2

Small-scale

0.963

High

1259662

WDR24
GATOR2 complex protein WDR24

3

3

Small-scale

0.656

High

1162287

WDR59
GATOR2 complex protein WDR59

3

4

Small-scale

0.640

High

1093434

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

1132332

SZT2
KICSTOR complex protein SZT2

2

0

Small-scale

0.585

High

1259653

ITFG2
KICSTOR complex protein ITFG2

2

0

Small-scale

0.585

High

1184610

RRAGA
Ras-related GTP-binding protein A

2

4

Small-scale

0.584

High

1259669

MIOS
GATOR2 complex protein MIOS

2

4

Small-scale

0.584

High

885134

SESN2
Sestrin-2

1

0

Small-scale

0.513

High

1044794

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.513

High

1162044

TRI65
E3 ubiquitin-protein ligase TRIM65

1

0

High-throughput

0.513

High

218048

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.489

High

952841

FOXK1
Forkhead box protein K1

1

1

High-throughput

0.489

High

964218

FOXK2
Forkhead box protein K2

1

1

High-throughput

0.489

High

1040764

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.489

High

1109717

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

1

High-throughput

0.489

High

1204636

MEX3D
RNA-binding protein MEX3D

1

1

High-throughput

0.489

High

1259648

CTF18
Chromosome transmission fidelity protein 18 homolog

1

1

High-throughput

0.489

High

758293

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.486

High

1139774

RRAGB
Ras-related GTP-binding protein B

1

4

Small-scale

0.479

High

1259654

SEH1
Nucleoporin SEH1

1

5

Small-scale

0.479

High

1259666

RRAGC
Ras-related GTP-binding protein C

1

4

Small-scale

0.479

High

1259667

RRAGD
Ras-related GTP-binding protein D

1

4

Small-scale

0.479

High

504463

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

507148

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

1229999

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.458

High

1259660

KICS2
KICSTOR subunit 2

1

0

Small-scale

0.458

High

1259676

KPTN
KICSTOR complex protein kaptin

1

0

Small-scale

0.458

High

1259668

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.437

High

1259657

ZN414
Zinc finger protein 414

3

0

High-throughput

0.347

High

166176

ZBTB5
Zinc finger and BTB domain-containing protein 5

2

0

High-throughput

0.328

High

1138574

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

2

0

High-throughput

0.328

High

1259651

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.328

High

896160

UBC12
NEDD8-conjugating enzyme Ubc12

2

0

Small-scale

0.313

High

1259650

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

152894

APAF
Apoptotic protease-activating factor 1

1

0

High-throughput

0.279

Low

182365

PER1
Period circadian protein homolog 1

1

0

High-throughput

0.279

Low

279028

RAD17
Cell cycle checkpoint protein RAD17

1

0

High-throughput

0.279

Low

312806

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

0

High-throughput

0.279

Low

413103

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.279

Low

589896

TBP
TATA-box-binding protein

1

0

High-throughput

0.279

Low

1038290

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

1063348

CND1
Condensin complex subunit 1

1

0

High-throughput

0.279

Low

1077778

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.279

Low

1082017

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.279

Low

1123289

PKHG4
Puratrophin-1

1

0

High-throughput

0.279

Low

1160424

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

1161331

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.279

Low

1162196

BRAT1
BRCA1-associated ATM activator 1

1

0

High-throughput

0.279

Low

1173382

STXB4
Syntaxin-binding protein 4

1

0

High-throughput

0.279

Low

1238466

BANP
Protein BANP

1

0

High-throughput

0.279

Low

1241988

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1259649

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.279

Low

1259652

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

0

High-throughput

0.279

Low

1259655

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

High-throughput

0.279

Low

1259656

TONSL
Tonsoku-like protein

1

0

High-throughput

0.279

Low

1259658

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

1259659

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low

1259661

RBM14
RNA-binding protein 14

1

0

High-throughput

0.279

Low

1259663

YTHD1
YTH domain-containing family protein 1

1

0

High-throughput

0.279

Low

1259665

ARP5
Actin-related protein 5

1

0

High-throughput

0.279

Low

1259674

FBX7
F-box only protein 7

1

0

High-throughput

0.279

Low

1259675

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.279

Low

498317

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

0

High-throughput

0.269

Low

589223

ANXA7
Annexin A7

1

0

High-throughput

0.265

Low

243520

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.249

Low

319941

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.249

Low

350390

RASK
GTPase KRas

1

0

High-throughput

0.249

Low

432102

HS90A
Heat shock protein HSP 90-alpha

1

0

High-throughput

0.249

Low

523080

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.249

Low

618135

COF1
Cofilin-1

1

0

High-throughput

0.249

Low

684916

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.249

Low

717230

CTNB1
Catenin beta-1

1

0

High-throughput

0.249

Low

741987

TALDO
Transaldolase

1

0

High-throughput

0.249

Low

794055

MATR3
Matrin-3

1

0

High-throughput

0.249

Low

965206

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.249

Low

1037317

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.249

Low

1060844

IMB1
Importin subunit beta-1

1

0

High-throughput

0.249

Low

1068023

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.249

Low

1071942

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.249

Low

1164569

NHS
Actin remodeling regulator NHS

1

0

High-throughput

0.249

Low

1259664

TB182
182 kDa tankyrase-1-binding protein

1

0

High-throughput

0.249

Low

1259670

CING
Cingulin

1

0

High-throughput

0.249

Low

1259671

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.249

Low

1259672

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.249

Low

1259673

RUVB2
RuvB-like 2

1

0

High-throughput

0.249

Low

1259677

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024