Protein: KPCB
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)

Gene: KPCB, PRKCB
Organism: Homo sapiens
Interactions: 209
UniProt ID: P05771

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0003682 - chromatin binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity
GO:0005080 - protein kinase C binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

408522

KPCB
Protein kinase C beta type

6

16

Small-scale

0.940

High

408561

AKT1
RAC-alpha serine/threonine-protein kinase

4

17

Small-scale

0.888

High

408549

KPCA
Protein kinase C alpha type

3

17

High-throughput

0.871

High

408557

ARBK1
Beta-adrenergic receptor kinase 1

2

17

Small-scale

0.834

High

408608

KPCD
Protein kinase C delta type

2

16

High-throughput

0.811

High

408644

GRP3
Ras guanyl-releasing protein 3

2

8

Small-scale

0.778

High

182071

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

19

Small-scale

0.768

High

408528

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.754

High

232762

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

15

Small-scale

0.747

High

161935

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

2

11

High-throughput

0.737

High

272841

KS6A4
Ribosomal protein S6 kinase alpha-4

2

17

High-throughput

0.737

High

408534

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

15

High-throughput

0.737

High

408535

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

15

High-throughput

0.737

High

408539

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

9

High-throughput

0.737

High

408573

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

7

High-throughput

0.737

High

408593

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

6

High-throughput

0.737

High

408603

SRSF2
Serine/arginine-rich splicing factor 2

2

5

High-throughput

0.737

High

408607

UBXN1
UBX domain-containing protein 1

2

1

High-throughput

0.737

High

408615

ZN638
Zinc finger protein 638

2

3

High-throughput

0.737

High

408622

CDC37
Hsp90 co-chaperone Cdc37

2

8

High-throughput

0.737

High

408628

CARL1
F-actin-uncapping protein LRRC16A

2

1

High-throughput

0.737

High

408640

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

11

High-throughput

0.737

High

408648

SRBD1
S1 RNA-binding domain-containing protein 1

2

1

High-throughput

0.737

High

408663

UHRF1
E3 ubiquitin-protein ligase UHRF1

2

3

High-throughput

0.737

High

408679

OSBL8
Oxysterol-binding protein-related protein 8

2

1

High-throughput

0.737

High

408697

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

14

High-throughput

0.737

High

408681

Q9H4D1
Protein kinase

1

7

Small-scale

0.724

High

408693

IBTK
Inhibitor of Bruton tyrosine kinase

1

7

Small-scale

0.724

High

408594

RACK1
Small ribosomal subunit protein RACK1

4

13

Small-scale

0.702

High

154113

CHK1
Serine/threonine-protein kinase Chk1

2

0

High-throughput

0.699

High

397122

KPCG
Protein kinase C gamma type

1

18

High-throughput

0.691

High

408678

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

4

12

Small-scale

0.680

High

408635

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

12

Small-scale

0.665

High

408702

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

5

High-throughput

0.665

High

362681

FINC
Fibronectin

1

0

High-throughput

0.656

High

408545

NCF1
Neutrophil cytosol factor 1

3

11

Small-scale

0.651

High

337764

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.647

High

408572

RGS2
Regulator of G-protein signaling 2

1

4

Small-scale

0.647

High

408579

GSK3A
Glycogen synthase kinase-3 alpha

1

19

Small-scale

0.647

High

408609

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.647

High

408612

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

Small-scale

0.647

High

408626

SYT6
Synaptotagmin-6

1

1

Small-scale

0.647

High

408647

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

408584

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

9

Small-scale

0.646

High

408649

SHCBP
SHC SH2 domain-binding protein 1

2

1

High-throughput

0.621

High

408538

TAU
Microtubule-associated protein tau

2

13

Small-scale

0.619

High

226260

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

408524

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.618

High

408527

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

408529

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

408543

NCAM1
Neural cell adhesion molecule 1

1

2

Small-scale

0.618

High

408544

DRD2
D(2) dopamine receptor

1

3

Small-scale

0.618

High

408568

DRD3
D(3) dopamine receptor

1

3

Small-scale

0.618

High

408569

PPM1A
Protein phosphatase 1A

1

1

Small-scale

0.618

High

408587

1433G
14-3-3 protein gamma

1

20

Small-scale

0.618

High

408595

ACTS
Actin, alpha skeletal muscle

1

9

Small-scale

0.618

High

408621

PKN1
Serine/threonine-protein kinase N1

1

16

Small-scale

0.618

High

408682

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

408554

LMNB1
Lamin-B1

2

13

Small-scale

0.595

High

408562

ARRB2
Beta-arrestin-2

2

5

Small-scale

0.584

High

408592

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

4

Small-scale

0.584

High

408601

CLH1
Clathrin heavy chain 1

2

3

Small-scale

0.584

High

408602

MDM2
E3 ubiquitin-protein ligase Mdm2

2

4

Small-scale

0.584

High

408652

TRI41
E3 ubiquitin-protein ligase TRIM41

1

7

Small-scale

0.578

High

408677

CAR11
Caspase recruitment domain-containing protein 11

1

13

Small-scale

0.578

High

241418

H2B1K
Histone H2B type 1-K

2

20

High-throughput

0.571

High

323543

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.571

High

388151

HSPB1
Heat shock protein beta-1

2

13

High-throughput

0.571

High

391498

H2A1B
Histone H2A type 1-B/E

2

10

High-throughput

0.571

High

408525

H2B1J
Histone H2B type 1-J

2

20

High-throughput

0.571

High

408532

H2AZ
Histone H2A.Z

2

12

High-throughput

0.571

High

408533

H2A1
Histone H2A type 1

2

10

High-throughput

0.571

High

408537

H14
Histone H1.4

2

18

High-throughput

0.571

High

408542

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

1

High-throughput

0.571

High

408546

H2AX
Histone H2AX

2

10

High-throughput

0.571

High

408548

H12
Histone H1.2

2

18

High-throughput

0.571

High

408553

H2A1D
Histone H2A type 1-D

2

10

High-throughput

0.571

High

408555

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

2

High-throughput

0.571

High

408558

HMGB2
High mobility group protein B2

2

12

High-throughput

0.571

High

408559

DPOD1
DNA polymerase delta catalytic subunit

2

1

High-throughput

0.571

High

408565

H2B1B
Histone H2B type 1-B

2

20

High-throughput

0.571

High

408570

ARL2
ADP-ribosylation factor-like protein 2

2

4

High-throughput

0.571

High

408574

RL27A
Large ribosomal subunit protein uL15

2

1

High-throughput

0.571

High

408575

COPD
Coatomer subunit delta

2

1

High-throughput

0.571

High

408581

MOT1
Monocarboxylate transporter 1

2

1

High-throughput

0.571

High

408583

H2BFS
Histone H2B type F-S

2

20

High-throughput

0.571

High

408585

H2B1D
Histone H2B type 1-D

2

20

High-throughput

0.571

High

408589

ERF1
Eukaryotic peptide chain release factor subunit 1

2

2

High-throughput

0.571

High

408590

H4
Histone H4

2

2

High-throughput

0.571

High

408596

TBA4A
Tubulin alpha-4A chain

2

13

High-throughput

0.571

High

408605

AKA12
A-kinase anchor protein 12

2

4

High-throughput

0.571

High

408614

LBR
Delta(14)-sterol reductase LBR

2

2

High-throughput

0.571

High

408616

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

6

High-throughput

0.571

High

408619

PCH2
Pachytene checkpoint protein 2 homolog

2

13

High-throughput

0.571

High

408620

MLF2
Myeloid leukemia factor 2

2

1

High-throughput

0.571

High

408623

H2A2C
Histone H2A type 2-C

2

10

High-throughput

0.571

High

408624

H2B2E
Histone H2B type 2-E

2

20

High-throughput

0.571

High

408625

EMAL3
Echinoderm microtubule-associated protein-like 3

2

2

High-throughput

0.571

High

408631

H2A2A
Histone H2A type 2-A

2

10

High-throughput

0.571

High

408636

H32
Histone H3.2

2

6

High-throughput

0.571

High

408637

H2AV
Histone H2A.V

2

12

High-throughput

0.571

High

408638

DDX46
Probable ATP-dependent RNA helicase DDX46

2

3

High-throughput

0.571

High

408639

H2A3
Histone H2A type 3

2

10

High-throughput

0.571

High

408642

DDX42
ATP-dependent RNA helicase DDX42

2

3

High-throughput

0.571

High

408645

CCAR1
Cell division cycle and apoptosis regulator protein 1

2

6

High-throughput

0.571

High

408646

CCAR2
Cell cycle and apoptosis regulator protein 2

2

1

High-throughput

0.571

High

408650

RHPN1
Rhophilin-1

2

7

High-throughput

0.571

High

408651

GEMI5
Gem-associated protein 5

2

6

High-throughput

0.571

High

408656

H2A1C
Histone H2A type 1-C

2

10

High-throughput

0.571

High

408661

H2A1H
Histone H2A type 1-H

2

10

High-throughput

0.571

High

408664

H2B1N
Histone H2B type 1-N

2

20

High-throughput

0.571

High

408665

H2A1J
Histone H2A type 1-J

2

10

High-throughput

0.571

High

408666

H2B1M
Histone H2B type 1-M

2

20

High-throughput

0.571

High

408667

H2B1L
Histone H2B type 1-L

2

20

High-throughput

0.571

High

408668

SH3G3
Endophilin-A3

2

6

High-throughput

0.571

High

408670

DDX50
ATP-dependent RNA helicase DDX50

2

4

High-throughput

0.571

High

408671

PELO
Protein pelota homolog

2

2

High-throughput

0.571

High

408674

H2AJ
Histone H2A.J

2

10

High-throughput

0.571

High

408683

DHX33
ATP-dependent RNA helicase DHX33

2

2

High-throughput

0.571

High

408685

PDLI7
PDZ and LIM domain protein 7

2

16

High-throughput

0.571

High

408686

DDX21
Nucleolar RNA helicase 2

2

4

High-throughput

0.571

High

408688

DDX18
ATP-dependent RNA helicase DDX18

2

3

High-throughput

0.571

High

408692

TECR
Very-long-chain enoyl-CoA reductase

2

1

High-throughput

0.571

High

408696

DIC
Mitochondrial dicarboxylate carrier

2

14

High-throughput

0.571

High

408698

ABCF2
ATP-binding cassette sub-family F member 2

2

1

High-throughput

0.571

High

408700

ACSL5
Long-chain-fatty-acid--CoA ligase 5

2

1

High-throughput

0.571

High

408597

H31
Histone H3.1

1

6

Small-scale

0.569

High

234766

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

1

Small-scale

0.561

High

321865

RIGI
Antiviral innate immune response receptor RIG-I

1

8

Small-scale

0.561

High

408567

HSP74
Heat shock 70 kDa protein 4

1

15

Small-scale

0.561

High

408659

RNF31
E3 ubiquitin-protein ligase RNF31

1

5

Small-scale

0.561

High

408660

PDLI5
PDZ and LIM domain protein 5

1

16

Small-scale

0.552

High

208505

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

2

0

High-throughput

0.547

High

315505

SC24A
Protein transport protein Sec24A

2

0

High-throughput

0.547

High

408530

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

2

0

High-throughput

0.547

High

408540

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

2

0

High-throughput

0.547

High

408552

IF2B
Eukaryotic translation initiation factor 2 subunit 2

2

0

High-throughput

0.547

High

408586

RL15
Large ribosomal subunit protein eL15

2

0

High-throughput

0.547

High

408641

ZC3C1
Zinc finger C3HC-type protein 1

2

0

High-throughput

0.547

High

408654

NDRG1
Protein NDRG1

2

0

High-throughput

0.547

High

408662

PURB
Transcriptional regulator protein Pur-beta

2

0

High-throughput

0.547

High

408669

GDF15
Growth/differentiation factor 15

2

0

High-throughput

0.547

High

408673

SEN34
tRNA-splicing endonuclease subunit Sen34

2

0

High-throughput

0.547

High

408675

TBCD
Tubulin-specific chaperone D

2

0

High-throughput

0.547

High

408680

MAGT1
Magnesium transporter protein 1

2

0

High-throughput

0.547

High

408687

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

2

0

High-throughput

0.547

High

408690

HPF1
Histone PARylation factor 1

2

0

High-throughput

0.547

High

408699

CPSF3
Cleavage and polyadenylation specificity factor subunit 3

2

0

High-throughput

0.547

High

408704

MTO1
Protein MTO1 homolog, mitochondrial

2

0

High-throughput

0.547

High

408672

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.543

High

408580

BIEA
Biliverdin reductase A

1

3

Small-scale

0.536

High

408706

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.536

High

231965

KDM1A
Lysine-specific histone demethylase 1A

1

2

Small-scale

0.536

High

408684

RDH14
Retinol dehydrogenase 14

1

2

High-throughput

0.536

High

408633

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

2

2

High-throughput

0.521

High

408653

AP3S1
AP-3 complex subunit sigma-1

2

2

High-throughput

0.521

High

408695

DHCR7
7-dehydrocholesterol reductase

2

2

High-throughput

0.521

High

408582

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

408551

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

7

Small-scale

0.515

High

408630

ADAL
Adenosine deaminase-like protein

1

1

High-throughput

0.515

High

408634

LIAT1
Protein LIAT1

1

1

High-throughput

0.515

High

309354

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.513

High

408658

COQ8B
Atypical kinase COQ8B, mitochondrial

1

0

High-throughput

0.513

High

362049

MBP
Myelin basic protein

1

6

Small-scale

0.501

High

396604

ITB2
Integrin beta-2

1

13

Small-scale

0.501

High

408523

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.501

High

408541

TOP2A
DNA topoisomerase 2-alpha

1

6

Small-scale

0.501

High

408547

H15
Histone H1.5

1

18

Small-scale

0.501

High

408560

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

Small-scale

0.501

High

408566

SDC2
Syndecan-2

1

4

Small-scale

0.501

High

408571

CASR
Extracellular calcium-sensing receptor

1

8

Small-scale

0.501

High

408576

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

7

Small-scale

0.501

High

408578

NUMB
Protein numb homolog

1

11

Small-scale

0.501

High

408588

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

10

Small-scale

0.501

High

408600

DAB2
Disabled homolog 2

1

16

Small-scale

0.501

High

408604

H11
Histone H1.1

1

18

Small-scale

0.501

High

408606

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

6

Small-scale

0.501

High

408611

EP300
Histone acetyltransferase p300

1

9

Small-scale

0.501

High

408613

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

Small-scale

0.501

High

408618

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.501

High

408701

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

5

Small-scale

0.501

High

408705

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

408627

MTCL3
Microtubule cross-linking factor 3

1

14

High-throughput

0.489

High

408526

H10
Histone H1.0

1

0

Small-scale

0.480

High

408550

DNLI1
DNA ligase 1

1

0

Small-scale

0.480

High

396547

ITB3
Integrin beta-3

1

13

Small-scale

0.479

High

408536

ANDR
Androgen receptor

1

11

Small-scale

0.479

High

408556

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

5

Small-scale

0.479

High

408563

IL3RB
Cytokine receptor common subunit beta

1

6

Small-scale

0.479

High

408577

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

408617

PDK1
[Pyruvate dehydrogenase

1

4

Small-scale

0.479

High

408629

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

408632

RICTR
Rapamycin-insensitive companion of mTOR

1

4

Small-scale

0.479

High

408655

REQU
Zinc finger protein ubi-d4

1

4

High-throughput

0.479

High

408564

LSP1
Lymphocyte-specific protein 1

1

0

Small-scale

0.458

High

408689

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

Small-scale

0.458

High

408610

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.457

High

408591

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.445

High

239243

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.298

High

408531

COX6C
Cytochrome c oxidase subunit 6C

2

0

High-throughput

0.298

High

408598

RT05
Small ribosomal subunit protein uS5m

2

0

High-throughput

0.298

High

408599

RT06
Small ribosomal subunit protein bS6m

2

0

High-throughput

0.298

High

408643

DOPP1
Dolichyldiphosphatase 1

2

0

High-throughput

0.298

High

408657

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

2

0

High-throughput

0.298

High

408676

DERL1
Derlin-1

2

0

High-throughput

0.298

High

408691

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

High-throughput

0.298

High

408703

MAN1
Inner nuclear membrane protein Man1

2

0

High-throughput

0.298

High

408694

DEC1
Deleted in esophageal cancer 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024