Protein: PRP19
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Complexed with cdc5 protein 8) (RING-type E3 ubiquitin transferase PRP19)

Gene: PRP19
Organism: Schizosaccharomyces pombe 972h-
Interactions: 93
UniProt ID: O14011

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

152503

PRP19
Pre-mRNA-processing factor 19

3

19

Small-scale

0.829

High

152574

BRR2
Pre-mRNA-splicing factor brr2

2

20

High-throughput

0.789

High

152515

PRP17
Pre-mRNA-processing factor 17

1

20

High-throughput

0.777

High

152571

SPF27
Pre-mRNA-splicing factor cwf7

2

0

Small-scale

0.766

High

152555

YN55
Uncharacterized WD repeat-containing protein C713.05

2

20

High-throughput

0.754

High

152556

YK99
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09

2

20

High-throughput

0.754

High

150419

PRP46
Pre-mRNA-splicing factor prp5

1

18

High-throughput

0.691

High

152511

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22

1

20

High-throughput

0.691

High

152513

DHX15
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43

1

20

High-throughput

0.691

High

152535

CWF17
Pre-mRNA-splicing factor cwf17

1

19

High-throughput

0.691

High

152560

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16

1

20

High-throughput

0.691

High

152530

SN114
Pre-mRNA-splicing factor cwf10

3

8

Small-scale

0.650

High

152557

YK96
Uncharacterized protein C20H4.06c

3

4

High-throughput

0.640

High

152506

SDE2
Splicing regulator sde2

3

0

Small-scale

0.628

High

152542

CWC2
Pre-mRNA-splicing factor cwf2

2

6

Small-scale

0.626

High

151421

YE02
Uncharacterized helicase C17H9.02

1

20

High-throughput

0.618

High

152553

CDC28
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28

1

20

High-throughput

0.618

High

152575

YIPH
Uncharacterized WD repeat-containing protein C343.17c

1

17

High-throughput

0.618

High

152526

CWF14
Pre-mRNA-splicing factor cwf14

2

3

Small-scale

0.611

High

152572

RU2A
U2 small nuclear ribonucleoprotein A'

2

7

High-throughput

0.611

High

152538

DSK1
Protein kinase dsk1

2

20

Small-scale

0.584

High

152578

YKR3
G-patch domain-containing protein C1486.03

2

13

High-throughput

0.584

High

152563

PRP11
Pre-mRNA-processing ATP-dependent RNA helicase prp11

1

9

High-throughput

0.575

High

152514

NRDE2
Protein NRDE2 homolog

2

0

Small-scale

0.559

High

152546

DRE4
Pre-mRNA-splicing factor dre4

1

7

High-throughput

0.554

High

151925

SA114
Pre-mRNA-splicing factor sap114

1

7

High-throughput

0.536

High

152505

SAP49
Spliceosome-associated protein 49

1

3

High-throughput

0.536

High

152508

SPP42
Pre-mRNA-splicing factor spp42

1

9

High-throughput

0.536

High

152512

SMD1
Small nuclear ribonucleoprotein Sm D1

1

20

High-throughput

0.536

High

152517

SAP61
Pre-mRNA-splicing factor sap61

1

3

High-throughput

0.536

High

152518

SYF2
Pre-mRNA-splicing factor syf2

1

3

High-throughput

0.536

High

152519

RUXF
Small nuclear ribonucleoprotein F

1

20

High-throughput

0.536

High

152521

SLT11
Pre-mRNA-splicing factor cwf5

1

6

High-throughput

0.536

High

152523

ISY1
Pre-mRNA-splicing factor cwf12

1

5

High-throughput

0.536

High

152528

RUXG
Small nuclear ribonucleoprotein G

1

20

High-throughput

0.536

High

152533

CWC26
Pre-mRNA-splicing factor cwf26

1

3

High-throughput

0.536

High

152534

CWF11
Pre-mRNA-splicing factor cwf11

1

10

High-throughput

0.536

High

152540

CWC15
Pre-mRNA-splicing factor cwf15

1

3

High-throughput

0.536

High

152544

CLF1
Pre-mRNA-splicing factor cwf4

1

20

High-throughput

0.536

High

152548

PRP45
Pre-mRNA-processing protein 45

1

7

High-throughput

0.536

High

152549

CWF19
Pre-mRNA-splicing factor cwf19

1

5

High-throughput

0.536

High

152550

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

20

High-throughput

0.536

High

152551

SF3B1
U2 snRNP component prp10

1

8

High-throughput

0.536

High

152562

YJU2
Splicing factor YJU2

1

6

High-throughput

0.536

High

152566

YHV5
Uncharacterized protein C211.05

1

1

High-throughput

0.536

High

152567

SYF1
Pre-mRNA-splicing factor cwf3

1

20

High-throughput

0.536

High

152573

RUXE
Small nuclear ribonucleoprotein E

1

5

High-throughput

0.536

High

152580

RSE1
Pre-mRNA-splicing factor prp12

1

17

High-throughput

0.536

High

152581

CWF18
Pre-mRNA-splicing factor cwf18

1

2

High-throughput

0.536

High

152582

SMD3
Small nuclear ribonucleoprotein Sm D3

1

20

High-throughput

0.536

High

152585

CWC25
Pre-mRNA-splicing factor cwf25

1

1

High-throughput

0.536

High

152504

YERE
WW domain-containing protein C2F3.14c

1

0

High-throughput

0.530

High

152524

SAF1
Protein saf1

1

0

High-throughput

0.530

High

152564

YLK3
Uncharacterized protein C1782.03

1

1

High-throughput

0.515

High

152507

CWC21
Pre-mRNA-splicing factor cwf21

1

0

High-throughput

0.513

High

152561

YK24
Uncharacterized protein C140.04

1

0

Small-scale

0.513

High

148902

PHD1
Histone deacetylase phd1

1

14

High-throughput

0.479

High

151243

ULP2
Ubiquitin-like-specific protease 2

1

8

Small-scale

0.479

High

151818

RSD1
RNA-binding protein rsd1

1

9

High-throughput

0.479

High

152509

YE6A
Uncharacterized protein C6G10.10c

1

1

High-throughput

0.479

High

152520

ESS2
Stress response protein bis1

1

2

High-throughput

0.479

High

152525

BBP
Branchpoint-bridging protein

1

5

High-throughput

0.479

High

152527

YBJC
Zinc finger CCCH domain-containing protein C337.12

1

4

High-throughput

0.479

High

152529

PRP39
Pre-mRNA-processing factor 39

1

20

High-throughput

0.479

High

152532

YHOC
Uncharacterized RNA-binding protein C428.12c

1

7

High-throughput

0.479

High

152537

HUB1
Ubiquitin-like modifier hub1

1

1

Small-scale

0.479

High

152539

U2AF2
Splicing factor U2AF 59 kDa subunit

1

15

High-throughput

0.479

High

152541

PPIL1
Peptidyl-prolyl cis-trans isomerase ppi1

1

6

High-throughput

0.479

High

152545

GAR1
H/ACA ribonucleoprotein complex subunit gar1

1

1

High-throughput

0.479

High

152552

MU161
CWF19-like protein mug161

1

6

High-throughput

0.479

High

152554

RU2B
Probable U2 small nuclear ribonucleoprotein B''

1

20

High-throughput

0.479

High

152558

CWC24
Pre-mRNA-splicing factor cwf24

1

8

High-throughput

0.479

High

152565

SAP62
Pre-mRNA-splicing factor sap62

1

4

High-throughput

0.479

High

152570

LUC7
U1 snRNP-associated protein usp106

1

2

High-throughput

0.479

High

152577

INI1
Pre-mRNA-splicing factor ini1

1

1

High-throughput

0.479

High

152579

RED1
NURS complex subunit red1

1

1

High-throughput

0.479

High

152583

SA145
Pre-mRNA-splicing factor sap145

1

2

High-throughput

0.479

High

151081

NAB2
Nuclear polyadenylated RNA-binding protein nab2

1

0

Small-scale

0.458

High

151182

YF28
Uncharacterized protein C17A2.08c

1

0

High-throughput

0.458

High

151304

ICLN
Splicing factor saf5

1

0

Small-scale

0.458

High

152531

PIR2
NURS complex subunit pir2

1

0

High-throughput

0.458

High

152536

CENPU
Inner kinetochore subunit mis17

1

0

Small-scale

0.458

High

152543

CENPI
Inner kinetochore subunit mis6

1

0

Small-scale

0.458

High

152568

FRG1
Protein frg1

1

0

High-throughput

0.458

High

152569

YJIA
Uncharacterized protein C5E4.10c

1

0

High-throughput

0.458

High

152584

MIS12
Centromere protein mis12

1

0

Small-scale

0.458

High

152516

SF3B6
Splicing factor 3B subunit 6-like protein

1

13

High-throughput

0.445

High

152522

CWC16
Protein saf4

1

6

High-throughput

0.445

High

152559

CWC22
Pre-mRNA-splicing factor cwf22

1

5

High-throughput

0.445

High

152510

YE8A
Probable inositol polyphosphate 5-phosphatase C9G1.10c

1

0

High-throughput

0.426

High

152576

ERG8
Phosphomevalonate kinase

1

0

High-throughput

0.426

High

152547

CP51
Lanosterol 14-alpha demethylase erg11

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025