Protein: SPD2A
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)

Gene: SPD2A, SH3PXD2A
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q5TCZ1

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0002102 - podosome
GO:0002020 - protease binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957984

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

4

11

High-throughput

0.881

High

992479

SOS1
Son of sevenless homolog 1

1

19

Small-scale

0.747

High

683422

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.722

High

1136525

AF1L2
Actin filament-associated protein 1-like 2

1

0

Small-scale

0.702

High

646977

1433T
14-3-3 protein theta

4

20

High-throughput

0.699

High

904687

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

927142

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

982111

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

924630

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.691

High

1132427

FBP1L
Formin-binding protein 1-like

1

14

High-throughput

0.691

High

1136522

MIB1
E3 ubiquitin-protein ligase MIB1

1

3

High-throughput

0.691

High

909656

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.635

High

1034754

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

3

18

Small-scale

0.622

High

196453

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.618

High

253361

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

20

High-throughput

0.618

High

523022

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

876411

AFAD
Afadin

1

16

High-throughput

0.618

High

1020176

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

8

High-throughput

0.618

High

1022402

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

High-throughput

0.618

High

1052222

SRC8
Src substrate cortactin

1

20

Small-scale

0.618

High

1136452

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

12

High-throughput

0.618

High

1136513

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.618

High

1136520

PHLB2
Pleckstrin homology-like domain family B member 2

1

6

High-throughput

0.618

High

1136521

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

16

High-throughput

0.618

High

1136523

KSR1
Kinase suppressor of Ras 1

1

10

High-throughput

0.618

High

1136537

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

11

High-throughput

0.618

High

1136538

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.618

High

1136542

RTKN
Rhotekin

1

2

High-throughput

0.618

High

1136546

PKHA5
Pleckstrin homology domain-containing family A member 5

1

15

High-throughput

0.618

High

1136563

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.618

High

1136564

GAB2
GRB2-associated-binding protein 2

1

13

High-throughput

0.618

High

871408

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

5

High-throughput

0.611

High

1136548

RTN4
Reticulon-4

2

2

High-throughput

0.611

High

1136553

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

1136535

ZN764
Zinc finger protein 764

2

2

High-throughput

0.574

High

1136544

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

2

18

Small-scale

0.565

High

231553

KIF1B
Kinesin-like protein KIF1B

1

10

High-throughput

0.553

High

384978

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

1136512

AN34A
Ankyrin repeat domain-containing protein 34A

1

10

High-throughput

0.553

High

1136530

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

19

High-throughput

0.553

High

1136547

TANC2
Protein TANC2

1

4

High-throughput

0.553

High

1136562

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

Small-scale

0.553

High

212430

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

2

High-throughput

0.536

High

851535

NEK4
Serine/threonine-protein kinase Nek4

1

13

High-throughput

0.536

High

1136527

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.536

High

881959

NETR
Neurotrypsin

1

0

High-throughput

0.517

High

313842

SVIL
Supervillin

1

1

Small-scale

0.481

High

230879

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

10

High-throughput

0.479

High

237230

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

264322

GGYF1
GRB10-interacting GYF protein 1

1

7

High-throughput

0.479

High

316255

NADK
NAD kinase

1

1

High-throughput

0.479

High

322742

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

549900

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

3

High-throughput

0.479

High

598484

NF1
Neurofibromin

1

8

High-throughput

0.479

High

647909

MARK3
MAP/microtubule affinity-regulating kinase 3

1

5

High-throughput

0.479

High

673486

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

673591

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.479

High

684099

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

880754

HDAC4
Histone deacetylase 4

1

7

High-throughput

0.479

High

894112

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

960377

CDK16
Cyclin-dependent kinase 16

1

1

High-throughput

0.479

High

997167

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.479

High

1025148

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

5

High-throughput

0.479

High

1026922

PAK2
Serine/threonine-protein kinase PAK 2

1

20

Small-scale

0.479

High

1057171

MELK
Maternal embryonic leucine zipper kinase

1

5

High-throughput

0.479

High

1076873

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

8

High-throughput

0.479

High

1136510

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

High-throughput

0.479

High

1136511

DEN4C
DENN domain-containing protein 4C

1

7

High-throughput

0.479

High

1136514

LARP1
La-related protein 1

1

3

High-throughput

0.479

High

1136515

GGYF2
GRB10-interacting GYF protein 2

1

14

High-throughput

0.479

High

1136517

MARK2
Serine/threonine-protein kinase MARK2

1

6

High-throughput

0.479

High

1136518

RFIP2
Rab11 family-interacting protein 2

1

6

High-throughput

0.479

High

1136519

MYCPP
C-myc promoter-binding protein

1

7

High-throughput

0.479

High

1136524

RPTOR
Regulatory-associated protein of mTOR

1

6

High-throughput

0.479

High

1136526

NAV1
Neuron navigator 1

1

4

High-throughput

0.479

High

1136528

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

1136529

DEN1A
DENN domain-containing protein 1A

1

7

High-throughput

0.479

High

1136531

HDAC7
Histone deacetylase 7

1

7

High-throughput

0.479

High

1136533

SRS12
Serine/arginine-rich splicing factor 12

1

6

High-throughput

0.479

High

1136539

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

1136540

F110A
Protein FAM110A

1

2

High-throughput

0.479

High

1136549

KI13B
Kinesin-like protein KIF13B

1

10

High-throughput

0.479

High

1136550

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

20

High-throughput

0.479

High

1136552

MARK1
Serine/threonine-protein kinase MARK1

1

6

High-throughput

0.479

High

1136556

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1136557

LIMA1
LIM domain and actin-binding protein 1

1

13

High-throughput

0.479

High

1136558

NGAP
Ras GTPase-activating protein nGAP

1

8

High-throughput

0.479

High

1136559

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.479

High

1136560

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

1136561

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1136565

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

1136566

STA13
StAR-related lipid transfer protein 13

1

20

High-throughput

0.479

High

1136567

TRAF6
TNF receptor-associated factor 6

1

8

Small-scale

0.479

High

154199

CHK1
Serine/threonine-protein kinase Chk1

1

0

High-throughput

0.458

High

1060543

ZN638
Zinc finger protein 638

1

0

High-throughput

0.458

High

1136534

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.458

High

1136536

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1136543

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

197606

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

18

Small-scale

0.457

High

815687

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

8

Small-scale

0.457

High

166571

DCLK1
Serine/threonine-protein kinase DCLK1

1

6

High-throughput

0.437

High

216936

KIF1C
Kinesin-like protein KIF1C

1

10

High-throughput

0.437

High

1080028

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

High-throughput

0.437

High

1109668

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

1136516

SYDE1
Rho GTPase-activating protein SYDE1

1

20

High-throughput

0.437

High

1136532

DEP1B
DEP domain-containing protein 1B

1

20

High-throughput

0.437

High

1136541

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.437

High

1136551

FA53C
Protein FAM53C

1

1

High-throughput

0.437

High

1136554

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.437

High

1136555

CING
Cingulin

1

2

High-throughput

0.437

High

1136568

KCTD3
BTB/POZ domain-containing protein KCTD3

1

7

High-throughput

0.437

High

991791

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

11

Small-scale

0.408

High

390950

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1136545

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024