Protein: NEK2
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)

Gene: NEK2
Organism: Homo sapiens
Interactions: 123
UniProt ID: P51955

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0000794 - condensed nuclear chromosome
GO:0000922 - spindle pole
GO:0001824 - blastocyst development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

851301

NEK2
Serine/threonine-protein kinase Nek2

3

19

Small-scale

0.863

High

851334

KIF24
Kinesin-like protein KIF24

1

12

Small-scale

0.747

High

851338

NEK11
Serine/threonine-protein kinase Nek11

1

19

Small-scale

0.747

High

658861

MK01
Mitogen-activated protein kinase 1

1

16

Small-scale

0.740

High

672790

CDC27
Cell division cycle protein 27 homolog

6

10

Small-scale

0.730

High

226921

PRKN
E3 ubiquitin-protein ligase parkin

1

16

Small-scale

0.724

High

851318

CDC16
Cell division cycle protein 16 homolog

5

12

Small-scale

0.712

High

851368

APC4
Anaphase-promoting complex subunit 4

6

0

Small-scale

0.699

High

851365

CDC23
Cell division cycle protein 23 homolog

4

12

Small-scale

0.694

High

737663

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

20

Small-scale

0.686

High

851317

CDC20
Cell division cycle protein 20 homolog

4

8

Small-scale

0.683

High

851369

ANC2
Anaphase-promoting complex subunit 2

4

10

Small-scale

0.683

High

851371

FZR1
Fizzy-related protein homolog

4

7

Small-scale

0.680

High

154940

NDC80
Kinetochore protein NDC80 homolog

3

20

Small-scale

0.664

High

851375

GIT1
ARF GTPase-activating protein GIT1

1

11

High-throughput

0.656

High

851367

APC5
Anaphase-promoting complex subunit 5

3

1

Small-scale

0.656

High

716895

CTNB1
Catenin beta-1

2

5

Small-scale

0.634

High

851354

APC1
Anaphase-promoting complex subunit 1

3

1

Small-scale

0.633

High

851366

APC7
Anaphase-promoting complex subunit 7

3

11

Small-scale

0.633

High

617485

CRCM
Colorectal mutant cancer protein

2

18

High-throughput

0.625

High

851339

CDC26
Anaphase-promoting complex subunit CDC26

3

0

High-throughput

0.622

High

851341

DTD1
D-aminoacyl-tRNA deacylase 1

2

1

High-throughput

0.621

High

616963

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

4

Small-scale

0.619

High

161336

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

9

Small-scale

0.618

High

161996

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

17

Small-scale

0.618

High

165650

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.618

High

438014

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.618

High

609768

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

17

Small-scale

0.618

High

682736

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

9

Small-scale

0.618

High

851302

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

9

Small-scale

0.618

High

851327

SF3B3
Splicing factor 3B subunit 3

1

4

Small-scale

0.618

High

851331

ACTBL
Beta-actin-like protein 2

1

16

Small-scale

0.618

High

851360

ANLN
Anillin

1

3

High-throughput

0.618

High

851364

ANFY1
Rabankyrin-5

1

5

Small-scale

0.618

High

851352

CP250
Centrosome-associated protein CEP250

2

17

Small-scale

0.606

High

851305

APC15
Anaphase-promoting complex subunit 15

2

0

High-throughput

0.602

High

851311

RHOB
Rho-related GTP-binding protein RhoB

1

15

Small-scale

0.590

High

851346

APC16
Anaphase-promoting complex subunit 16

2

0

High-throughput

0.585

High

536762

TRI27
Zinc finger protein RFP

2

6

Small-scale

0.584

High

851321

BFSP2
Phakinin

2

4

High-throughput

0.574

High

176576

FANCA
Fanconi anemia group A protein

1

2

Small-scale

0.573

High

851347

CC85A
Coiled-coil domain-containing protein 85A

2

1

High-throughput

0.570

High

851362

CALL5
Calmodulin-like protein 5

1

20

Small-scale

0.553

High

851343

CLC4C
C-type lectin domain family 4 member C

1

1

Small-scale

0.552

High

851377

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

851337

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.513

High

851344

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

851351

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

418919

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.508

High

851308

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

19

Small-scale

0.508

High

851324

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.508

High

851325

IF4A2
Eukaryotic initiation factor 4A-II

1

11

High-throughput

0.508

High

851335

MYOME
Myomegalin

1

20

High-throughput

0.508

High

851348

IF140
Intraflagellar transport protein 140 homolog

1

4

High-throughput

0.508

High

851355

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

14

High-throughput

0.508

High

851322

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

851358

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

9

Small-scale

0.501

High

851353

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.493

High

851330

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.486

High

851350

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.486

High

851340

CIP2A
Protein CIP2A

1

10

Small-scale

0.481

High

236899

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

19

Small-scale

0.479

High

373366

CATA
Catalase

1

3

Small-scale

0.479

High

380987

SEMG1
Semenogelin-1

1

1

Small-scale

0.479

High

381876

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

Small-scale

0.479

High

396333

APOD
Apolipoprotein D

1

1

Small-scale

0.479

High

400799

RLA0
Large ribosomal subunit protein uL10

1

3

Small-scale

0.479

High

418063

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

427496

ANXA2
Annexin A2

1

4

Small-scale

0.479

High

443411

VIME
Vimentin

1

14

Small-scale

0.479

High

501855

BIP
Endoplasmic reticulum chaperone BiP

1

19

Small-scale

0.479

High

503722

HSP7C
Heat shock cognate 71 kDa protein

1

15

Small-scale

0.479

High

531088

EF2
Elongation factor 2

1

8

Small-scale

0.479

High

542239

PLAK
Junction plakoglobin

1

5

Small-scale

0.479

High

572900

PRS6A
26S proteasome regulatory subunit 6A

1

10

Small-scale

0.479

High

584909

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

Small-scale

0.479

High

678258

COR1A
Coronin-1A

1

8

Small-scale

0.479

High

678425

S10A7
Protein S100-A7

1

8

Small-scale

0.479

High

685648

PRDX2
Peroxiredoxin-2

1

9

Small-scale

0.479

High

713928

HS71L
Heat shock 70 kDa protein 1-like

1

15

Small-scale

0.479

High

724726

MYH9
Myosin-9

1

17

Small-scale

0.479

High

730220

PRS7
26S proteasome regulatory subunit 7

1

6

Small-scale

0.479

High

751547

GRP75
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

798617

PRS6B
26S proteasome regulatory subunit 6B

1

4

Small-scale

0.479

High

812965

CAZA2
F-actin-capping protein subunit alpha-2

1

7

Small-scale

0.479

High

851303

CAZA1
F-actin-capping protein subunit alpha-1

1

7

Small-scale

0.479

High

851304

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.479

High

851306

IF4A1
Eukaryotic initiation factor 4A-I

1

8

Small-scale

0.479

High

851307

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

Small-scale

0.479

High

851309

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

19

Small-scale

0.479

High

851310

PRS10
26S proteasome regulatory subunit 10B

1

7

Small-scale

0.479

High

851312

H4
Histone H4

1

4

Small-scale

0.479

High

851313

EF1A1
Elongation factor 1-alpha 1

1

5

Small-scale

0.479

High

851314

SEMG2
Semenogelin-2

1

1

Small-scale

0.479

High

851315

DSG1
Desmoglein-1

1

5

Small-scale

0.479

High

851319

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

5

Small-scale

0.479

High

851323

PKP1
Plakophilin-1

1

6

Small-scale

0.479

High

851326

BECN1
Beclin-1

1

2

Small-scale

0.479

High

851332

ODFP2
Outer dense fiber protein 2

1

20

High-throughput

0.479

High

851333

FILA2
Filaggrin-2

1

9

Small-scale

0.479

High

851345

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

Small-scale

0.479

High

851349

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.479

High

851356

RNF41
E3 ubiquitin-protein ligase NRDP1

1

13

Small-scale

0.479

High

851359

NRK2
Nicotinamide riboside kinase 2

1

1

Small-scale

0.479

High

851372

APC10
Anaphase-promoting complex subunit 10

1

5

High-throughput

0.479

High

851373

RUVB2
RuvB-like 2

1

6

Small-scale

0.479

High

851374

TR150
Thyroid hormone receptor-associated protein 3

1

7

Small-scale

0.479

High

851376

MYO5A
Unconventional myosin-Va

1

14

Small-scale

0.479

High

851329

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.464

High

851320

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

409363

CASB
Beta-casein

1

2

Small-scale

0.457

High

714749

TRY3
Trypsin-3

1

1

Small-scale

0.437

High

851316

DSC1
Desmocollin-1

1

8

Small-scale

0.437

High

851342

LRC15
Leucine-rich repeat-containing protein 15

1

1

Small-scale

0.437

High

851361

TMOD3
Tropomodulin-3

1

4

Small-scale

0.437

High

851370

COR1C
Coronin-1C

1

10

Small-scale

0.437

High

851336

CP087
UPF0547 protein C16orf87

1

0

High-throughput

0.279

Low

851363

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

498389

CMGA
Chromogranin-A

1

0

High-throughput

0.265

Low

782713

IPP2
Protein phosphatase inhibitor 2

1

0

Small-scale

0.261

Low

851328

CDSN
Corneodesmosin

1

0

Small-scale

0.249

Low

851357

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024