Protein: SH21A
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)

Gene: SH21A, SH2D1A
Organism: Homo sapiens
Interactions: 53
UniProt ID: O60880

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006959 - humoral immune response
GO:0006968 - cellular defense response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

243121

FYN
Tyrosine-protein kinase Fyn

4

17

Small-scale

0.894

High

243136

ACK1
Activated CDC42 kinase 1

2

19

High-throughput

0.845

High

243141

ARHG7
Rho guanine nucleotide exchange factor 7

2

20

Small-scale

0.781

High

243116

EGFR
Epidermal growth factor receptor

2

20

High-throughput

0.778

High

243127

NCK1
SH2/SH3 adapter protein NCK1

2

19

High-throughput

0.767

High

243135

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.767

High

243137

SLAF1
Signaling lymphocytic activation molecule

15

20

Small-scale

0.762

High

243155

CD244
Natural killer cell receptor 2B4

12

20

Small-scale

0.756

High

243148

NGEF
Ephexin-1

2

20

High-throughput

0.743

High

243161

SLAF5
SLAM family member 5

7

20

Small-scale

0.738

High

243153

SLAF6
SLAM family member 6

6

20

Small-scale

0.728

High

243120

LCK
Tyrosine-protein kinase Lck

2

17

Small-scale

0.726

High

167731

FYB1
FYN-binding protein 1

1

20

Small-scale

0.713

High

243131

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.696

High

243142

ARHG6
Rho guanine nucleotide exchange factor 6

1

20

Small-scale

0.683

High

243126

SRC
Proto-oncogene tyrosine-protein kinase Src

1

17

High-throughput

0.665

High

243118

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

243143

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

243157

LY9
T-lymphocyte surface antigen Ly-9

4

20

Small-scale

0.632

High

243123

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

243125

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.619

High

243122

LYN
Tyrosine-protein kinase Lyn

1

17

Small-scale

0.618

High

243150

LHX4
LIM/homeobox protein Lhx4

2

7

High-throughput

0.600

High

243158

SLAF7
SLAM family member 7

2

20

Small-scale

0.595

High

243154

DOK1
Docking protein 1

1

20

Small-scale

0.586

High

155819

SH21B
SH2 domain-containing protein 1B

1

19

Small-scale

0.575

High

243130

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

6

Small-scale

0.554

High

243160

LHX3
LIM/homeobox protein Lhx3

2

7

High-throughput

0.553

High

243128

ATF3
Cyclic AMP-dependent transcription factor ATF-3

2

7

High-throughput

0.542

High

243124

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

243146

LTMD1
LETM1 domain-containing protein 1

2

1

High-throughput

0.526

High

243149

OLIG1
Oligodendrocyte transcription factor 1

2

4

High-throughput

0.526

High

243129

CD22
B-cell receptor CD22

1

20

Small-scale

0.515

High

243156

NIF3L
NIF3-like protein 1

1

2

High-throughput

0.515

High

243117

FOS
Protein c-Fos

1

6

High-throughput

0.515

High

243152

DDT4L
DNA damage-inducible transcript 4-like protein

1

4

High-throughput

0.515

High

243144

MK11
Mitogen-activated protein kinase 11

1

9

Small-scale

0.501

High

243145

MK14
Mitogen-activated protein kinase 14

1

9

Small-scale

0.501

High

243134

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.500

High

243163

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

20

High-throughput

0.489

High

211413

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.479

High

243133

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.479

High

243138

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

18

High-throughput

0.479

High

243139

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

14

High-throughput

0.479

High

243140

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

12

High-throughput

0.479

High

177593

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.437

High

243119

CD5
T-cell surface glycoprotein CD5

1

4

Small-scale

0.437

High

243132

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

20

Small-scale

0.437

High

243159

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

8

Small-scale

0.437

High

243162

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.437

High

199160

ZNHI1
Zinc finger HIT domain-containing protein 1

2

0

High-throughput

0.310

High

243151

CC74A
Coiled-coil domain-containing protein 74A

2

0

High-throughput

0.300

High

243147

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024