Protein: HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase)

Gene: HMGCL
Organism: Homo sapiens
Interactions: 40
UniProt ID: P35914

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004419 - hydroxymethylglutaryl-CoA lyase activity
GO:0005198 - structural molecule activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

729223

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

2

13

High-throughput

0.789

High

300721

GLSK
Glutaminase kidney isoform, mitochondrial

3

1

High-throughput

0.656

High

526365

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

3

1

High-throughput

0.656

High

729210

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

3

2

High-throughput

0.656

High

729214

FOLC
Folylpolyglutamate synthase, mitochondrial

3

1

High-throughput

0.656

High

729228

MGME1
Mitochondrial genome maintenance exonuclease 1

3

1

High-throughput

0.656

High

729225

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.611

High

301075

FBX21
F-box only protein 21

2

0

High-throughput

0.585

High

729224

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

2

0

High-throughput

0.585

High

158415

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.578

High

729209

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.561

High

398330

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

3

High-throughput

0.536

High

642839

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

729234

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

505940

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

729212

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.513

High

729219

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

729221

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

729222

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

729227

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.513

High

729230

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

1

0

High-throughput

0.513

High

681348

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.508

High

729232

ATS10
A disintegrin and metalloproteinase with thrombospondin motifs 10

1

2

High-throughput

0.508

High

475420

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

729213

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.494

High

729218

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.486

High

729229

RN126
E3 ubiquitin-protein ligase RNF126

1

0

High-throughput

0.486

High

729208

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

729215

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

729226

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.460

High

299327

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

373356

CATA
Catalase

1

0

High-throughput

0.458

High

729235

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

729220

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

729233

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

729211

PEX5
Peroxisomal targeting signal 1 receptor

1

2

Small-scale

0.408

High

729231

MS4A7
Membrane-spanning 4-domains subfamily A member 7

1

0

High-throughput

0.282

High

729217

HES1
Transcription factor HES-1

1

0

High-throughput

0.265

Low

351961

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

729216

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024