Protein: DOK1
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)

Gene: DOK1
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q99704

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction
GO:0007166 - cell surface receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

596429

RASA1
Ras GTPase-activating protein 1

9

20

Small-scale

0.966

High

337542

ABL1
Tyrosine-protein kinase ABL1

6

20

Small-scale

0.949

High

802892

CRKL
Crk-like protein

5

20

Small-scale

0.928

High

209149

NCK2
Cytoplasmic protein NCK2

4

20

Small-scale

0.899

High

338891

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.858

High

789005

TEC
Tyrosine-protein kinase Tec

2

20

Small-scale

0.825

High

433966

LYN
Tyrosine-protein kinase Lyn

2

20

Small-scale

0.799

High

1184737

DOK3
Docking protein 3

2

11

High-throughput

0.767

High

1305739

SRMS
Tyrosine-protein kinase Srms

1

20

Small-scale

0.761

High

434273

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

Small-scale

0.740

High

454844

FGR
Tyrosine-protein kinase Fgr

2

20

Small-scale

0.738

High

523124

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.738

High

557780

NCK1
SH2/SH3 adapter protein NCK1

2

20

Small-scale

0.727

High

158531

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

5

Small-scale

0.724

High

499285

KIT
Mast/stem cell growth factor receptor Kit

1

10

Small-scale

0.724

High

506649

BCR
Breakpoint cluster region protein

1

4

Small-scale

0.724

High

851650

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.691

High

639914

ITB7
Integrin beta-7

2

4

Small-scale

0.687

High

383949

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

396595

ITB3
Integrin beta-3

1

4

Small-scale

0.647

High

403952

ITB1
Integrin beta-1

1

4

Small-scale

0.647

High

411486

INSR
Insulin receptor

1

20

Small-scale

0.647

High

433460

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.647

High

442876

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.647

High

581044

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

5

Small-scale

0.647

High

1305740

TLN1
Talin-1

1

3

Small-scale

0.647

High

1271564

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

3

7

Small-scale

0.646

High

235099

DOK2
Docking protein 2

1

13

Small-scale

0.618

High

924816

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

1146772

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.618

High

1305736

DOK1
Docking protein 1

1

11

Small-scale

0.618

High

243154

SH21A
SH2 domain-containing protein 1A

1

20

Small-scale

0.586

High

655452

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.571

High

666161

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.563

High

396648

ITB2
Integrin beta-2

1

4

Small-scale

0.553

High

548746

VAV
Proto-oncogene vav

1

15

Small-scale

0.527

High

789086

ABL2
Tyrosine-protein kinase ABL2

1

20

Small-scale

0.527

High

802714

CRK
Adapter molecule crk

1

20

Small-scale

0.527

High

996570

ITK
Tyrosine-protein kinase ITK/TSK

1

20

Small-scale

0.527

High

1046417

PTK6
Protein-tyrosine kinase 6

1

20

Small-scale

0.527

High

1175962

HAKAI
E3 ubiquitin-protein ligase Hakai

1

1

Small-scale

0.479

High

499357

CD28
T-cell-specific surface glycoprotein CD28

1

0

Small-scale

0.458

High

891281

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

986022

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

15

Small-scale

0.445

High

1305737

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.445

High

1305738

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

1223327

GT252
Procollagen galactosyltransferase 2

2

0

High-throughput

0.328

High


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Last updated: 15 Jul 2024