Protein: CD59
CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)

Gene: CD59
Organism: Homo sapiens
Interactions: 86
UniProt ID: P13987

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001848 - complement binding
GO:0001971 - negative regulation of activation of membrane attack complex
GO:0005615 - extracellular space
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534211

TX101
Testis-expressed protein 101

1

0

High-throughput

0.656

High

534215

TINAL
Tubulointerstitial nephritis antigen-like

3

0

High-throughput

0.638

High

528462

CFTR
Cystic fibrosis transmembrane conductance regulator

3

0

High-throughput

0.616

High

353328

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

0

Small-scale

0.614

High

362608

CO9
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

2

1

Small-scale

0.602

High

534201

TM11B
Transmembrane protease serine 11B

2

0

High-throughput

0.602

High

158897

NCTR3
Natural cytotoxicity triggering receptor 3

1

0

Small-scale

0.586

High

534167

CD27
CD27 antigen

2

0

High-throughput

0.585

High

534198

F209A
Protein FAM209A

2

0

High-throughput

0.580

High

368911

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

534172

CCR2
C-C chemokine receptor type 2

1

1

High-throughput

0.541

High

534168

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

534220

PARVG
Gamma-parvin

1

1

High-throughput

0.536

High

436892

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.518

High

274914

RENR
Renin receptor

1

0

High-throughput

0.513

High

277558

DHRS3
Short-chain dehydrogenase/reductase 3

1

0

High-throughput

0.513

High

443026

ITA5
Integrin alpha-5

1

0

High-throughput

0.513

High

445149

IBP1
Insulin-like growth factor-binding protein 1

1

0

High-throughput

0.513

High

534165

FLNA
Filamin-A

1

0

High-throughput

0.513

High

534166

PRPH2
Peripherin-2

1

0

High-throughput

0.513

High

534169

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.513

High

534175

MSS4
Guanine nucleotide exchange factor MSS4

1

0

High-throughput

0.513

High

534180

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

534193

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

534194

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

534203

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

534221

KC1G1
Casein kinase I isoform gamma-1

1

0

High-throughput

0.513

High

534229

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

427740

CO8A
Complement component C8 alpha chain

1

1

Small-scale

0.501

High

344087

ISK1
Serine protease inhibitor Kazal-type 1

1

0

High-throughput

0.493

High

534192

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

Small-scale

0.493

High

534202

PIM3
Serine/threonine-protein kinase pim-3

1

1

High-throughput

0.489

High

337859

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.480

High

534183

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

534189

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

534213

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.460

High

204988

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

282181

NCTR1
Natural cytotoxicity triggering receptor 1

1

0

Small-scale

0.458

High

344931

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

534170

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

0

High-throughput

0.458

High

534171

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

534174

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

534179

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

534187

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

534191

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

534212

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

534217

SIK2
Serine/threonine-protein kinase SIK2

1

0

Small-scale

0.458

High

534218

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

301587

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.437

High

308369

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

534178

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.437

High

534206

RN138
E3 ubiquitin-protein ligase RNF138

1

1

High-throughput

0.437

High

534207

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

534216

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.437

High

534225

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.437

High

534228

RNF6
E3 ubiquitin-protein ligase RNF6

1

1

High-throughput

0.437

High

534199

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

0

Small-scale

0.426

High

534210

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

534182

GALK2
N-acetylgalactosamine kinase

2

0

High-throughput

0.328

High

534177

UBE2A
Ubiquitin-conjugating enzyme E2 A

2

0

High-throughput

0.318

High

534173

HD
Huntingtin

2

0

High-throughput

0.306

High

534184

DUS4
Dual specificity protein phosphatase 4

2

0

High-throughput

0.298

High

534195

DREB
Drebrin

1

0

High-throughput

0.279

Low

534204

TBCK
TBC domain-containing protein kinase-like protein

1

0

High-throughput

0.279

Low

534205

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

534208

TP4A1
Protein tyrosine phosphatase type IVA 1

1

0

High-throughput

0.279

Low

534209

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.279

Low

534186

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.265

Low

233188

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

345820

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

534164

BTF3
Transcription factor BTF3

1

0

High-throughput

0.249

Low

534176

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

534181

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

534188

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

534190

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

534196

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.249

Low

534197

MIDN
Midnolin

1

0

High-throughput

0.249

Low

534200

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

534214

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.249

Low

534219

ECT2
Protein ECT2

1

0

High-throughput

0.249

Low

534222

ANLN
Anillin

1

0

High-throughput

0.249

Low

534223

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

534224

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.249

Low

534226

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

534227

SEPT9
Septin-9

1

0

Small-scale

0.249

Low

534185

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024