Protein: PGH2
Prostaglandin G/H synthase 2 (EC 1.14.99.1) (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2)

Gene: PGH2, PTGS2
Organism: Homo sapiens
Interactions: 49
UniProt ID: P35354

Gene Ontology (top 5):
GO:0001516 - prostaglandin biosynthetic process
GO:0001525 - angiogenesis
GO:0004601 - peroxidase activity
GO:0004666 - prostaglandin-endoperoxide synthase activity
GO:0005637 - nuclear inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

722958

PGH2
Prostaglandin G/H synthase 2

4

2

Small-scale

0.896

High

386209

P53
Cellular tumor antigen p53

6

0

Small-scale

0.703

High

722967

CAV1
Caveolin-1

3

2

Small-scale

0.683

High

722976

ELAV1
ELAV-like protein 1

3

1

Small-scale

0.640

High

613156

PGH1
Prostaglandin G/H synthase 1

1

2

Small-scale

0.618

High

722965

SUMO1
Small ubiquitin-related modifier 1

3

0

Small-scale

0.613

High

722969

EP300
Histone acetyltransferase p300

3

0

Small-scale

0.613

High

722986

LMA2L
VIP36-like protein

2

0

High-throughput

0.602

High

722960

CEBPD
CCAAT/enhancer-binding protein delta

3

4

Small-scale

0.585

High

401520

JUN
Transcription factor Jun

2

2

Small-scale

0.584

High

722968

TF65
Transcription factor p65

2

1

Small-scale

0.584

High

722989

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

Small-scale

0.578

High

722966

NUCB1
Nucleobindin-1

1

2

Small-scale

0.561

High

722981

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.554

High

722987

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.537

High

159164

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.518

High

722973

CUL1
Cullin-1

1

3

Small-scale

0.515

High

722988

CSN3
COP9 signalosome complex subunit 3

1

1

Small-scale

0.515

High

722977

PTGIS
Prostacyclin synthase

1

2

Small-scale

0.501

High

382328

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.493

High

345354

FOS
Protein c-Fos

1

1

Small-scale

0.479

High

346086

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

569292

CEBPB
CCAAT/enhancer-binding protein beta

1

3

Small-scale

0.479

High

587449

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.479

High

647486

MK03
Mitogen-activated protein kinase 3

1

2

Small-scale

0.479

High

674829

AGTR1
Type-1 angiotensin II receptor

1

1

Small-scale

0.479

High

714724

PE2R1
Prostaglandin E2 receptor EP1 subtype

1

1

Small-scale

0.479

High

722962

HDAC4
Histone deacetylase 4

1

1

Small-scale

0.479

High

722974

CUL4A
Cullin-4A

1

3

Small-scale

0.479

High

394218

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.458

High

556795

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

722959

PA24A
Cytosolic phospholipase A2

1

0

Small-scale

0.458

High

722961

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

722963

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.458

High

722964

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

722970

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

722972

HDAC1
Histone deacetylase 1

1

0

Small-scale

0.458

High

722980

ELMO1
Engulfment and cell motility protein 1

1

0

Small-scale

0.458

High

722982

FAF2
FAS-associated factor 2

1

0

High-throughput

0.458

High

722984

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

722985

DERL1
Derlin-1

1

0

Small-scale

0.458

High

528672

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

722975

CASP8
Caspase-8

1

0

High-throughput

0.426

High

722978

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

224329

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.417

High

722983

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

Small-scale

0.269

Low

722979

Q86V38
Atrophin 1

1

0

High-throughput

0.268

Low

722971

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024