Protein: CDK12
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)

Gene: CDK12
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q9NYV4

Gene Ontology (top 5):
GO:0002944 - cyclin K-CDK12 complex
GO:0004672 - protein kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

277547

CCNK
Cyclin-K

4

20

Small-scale

0.890

High

841911

CDK9
Cyclin-dependent kinase 9

3

17

High-throughput

0.871

High

1047638

CDK13
Cyclin-dependent kinase 13

3

18

High-throughput

0.861

High

934522

CSK21
Casein kinase II subunit alpha

2

19

High-throughput

0.811

High

942993

SRPK2
SRSF protein kinase 2

2

19

High-throughput

0.799

High

967476

EWS
RNA-binding protein EWS

2

8

High-throughput

0.757

High

1082428

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.692

High

824678

MAPK2
MAP kinase-activated protein kinase 2

1

14

High-throughput

0.691

High

992970

SRSF1
Serine/arginine-rich splicing factor 1

1

20

High-throughput

0.691

High

993856

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

1028854

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.691

High

1029138

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

1070669

RNPS1
RNA-binding protein with serine-rich domain 1

1

11

High-throughput

0.691

High

1224583

CDK20
Cyclin-dependent kinase 20

1

17

High-throughput

0.691

High

1311141

ZNF2
Zinc finger protein 2

1

2

High-throughput

0.691

High

1348699

TPX2
Targeting protein for Xklp2

1

3

High-throughput

0.691

High

833827

CLK1
Dual specificity protein kinase CLK1

1

16

High-throughput

0.647

High

814672

CDX1
Homeobox protein CDX-1

2

1

High-throughput

0.628

High

1348697

ANR50
Ankyrin repeat domain-containing protein 50

1

5

High-throughput

0.618

High

228911

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.618

High

374991

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

442551

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.618

High

706817

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

16

High-throughput

0.618

High

780218

CCNF
Cyclin-F

1

20

High-throughput

0.618

High

895456

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

16

High-throughput

0.618

High

932412

ACTC
Actin, alpha cardiac muscle 1

1

8

High-throughput

0.618

High

1048052

CCNI
Cyclin-I

1

20

High-throughput

0.618

High

1054628

RBM39
RNA-binding protein 39

1

9

Small-scale

0.618

High

1055492

DHX8
ATP-dependent RNA helicase DHX8

1

5

High-throughput

0.618

High

1116589

LARP7
La-related protein 7

1

16

High-throughput

0.618

High

1255164

CABL1
CDK5 and ABL1 enzyme substrate 1

1

6

High-throughput

0.618

High

1305966

BARD1
BRCA1-associated RING domain protein 1

1

10

High-throughput

0.618

High

1348692

AFF4
AF4/FMR2 family member 4

1

13

High-throughput

0.618

High

1348698

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.618

High

263854

PR40A
Pre-mRNA-processing factor 40 homolog A

2

12

High-throughput

0.605

High

900294

RL37A
Large ribosomal subunit protein eL43

2

0

High-throughput

0.602

High

1130666

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

17

High-throughput

0.575

High

370582

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

910096

1433E
14-3-3 protein epsilon

2

8

High-throughput

0.571

High

879353

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

10

High-throughput

0.553

High

1172019

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.553

High

1312388

CABL2
CDK5 and ABL1 enzyme substrate 2

1

6

High-throughput

0.553

High

1331471

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.553

High

905187

1433G
14-3-3 protein gamma

2

20

High-throughput

0.549

High

180491

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.536

High

269919

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

14

High-throughput

0.536

High

401152

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.536

High

616560

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.536

High

642648

RL13
Large ribosomal subunit protein eL13

1

4

High-throughput

0.536

High

736778

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

773607

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.536

High

802247

NOP2
Probable 28S rRNA

1

2

High-throughput

0.536

High

899384

RL15
Large ribosomal subunit protein eL15

1

2

High-throughput

0.536

High

907567

RS8
Small ribosomal subunit protein eS8

1

4

High-throughput

0.536

High

910602

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.536

High

916931

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.536

High

944970

RED1
Double-stranded RNA-specific editase 1

1

8

High-throughput

0.536

High

958535

CYC
Cytochrome c

1

2

High-throughput

0.536

High

1039900

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1065896

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

High-throughput

0.536

High

1264679

DGCR8
Microprocessor complex subunit DGCR8

1

1

High-throughput

0.536

High

1271112

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

High-throughput

0.536

High

1312237

H2AJ
Histone H2A.J

1

7

High-throughput

0.536

High

1332695

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.536

High

1334573

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.536

High

1348469

BCLF1
Bcl-2-associated transcription factor 1

1

7

High-throughput

0.536

High

1348694

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

1348696

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

887620

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1348700

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

1038074

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.501

High

625072

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

11

Small-scale

0.500

High

1158333

CDC73
Parafibromin

1

2

Small-scale

0.500

High

1237163

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

Small-scale

0.500

High

174160

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.489

High

806717

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.489

High

875587

FGF8
Fibroblast growth factor 8

1

1

High-throughput

0.489

High

949067

HTRA4
Serine protease HTRA4

1

5

High-throughput

0.489

High

1054948

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

1348704

RL36
Large ribosomal subunit protein eL36

1

3

High-throughput

0.489

High

203315

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

2

High-throughput

0.479

High

214396

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.479

High

245029

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

303509

HEXI1
Protein HEXIM1

1

10

High-throughput

0.479

High

304374

UBR5
E3 ubiquitin-protein ligase UBR5

1

12

High-throughput

0.479

High

320041

HERC2
E3 ubiquitin-protein ligase HERC2

1

8

High-throughput

0.479

High

348078

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

379954

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

524044

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

553906

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

560421

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

2

Small-scale

0.479

High

575202

RL7
Large ribosomal subunit protein uL30

1

3

High-throughput

0.479

High

584641

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

7

High-throughput

0.479

High

652443

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

721626

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

738087

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

16

High-throughput

0.479

High

742567

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

808973

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

818538

SOX2
Transcription factor SOX-2

1

4

Small-scale

0.479

High

909238

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

932899

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.479

High

941512

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.479

High

942449

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

6

High-throughput

0.479

High

959724

VIGLN
Vigilin

1

14

High-throughput

0.479

High

974524

ENL
Protein ENL

1

15

High-throughput

0.479

High

980892

TLE3
Transducin-like enhancer protein 3

1

10

High-throughput

0.479

High

999150

EP300
Histone acetyltransferase p300

1

15

High-throughput

0.479

High

1027295

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

1029954

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.479

High

1031289

SKP2
S-phase kinase-associated protein 2

1

8

High-throughput

0.479

High

1061082

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

10

High-throughput

0.479

High

1169195

RN111
E3 ubiquitin-protein ligase Arkadia

1

3

High-throughput

0.479

High

1173259

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.479

High

1188956

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1200703

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1201723

ZCH18
Zinc finger CCCH domain-containing protein 18

1

10

High-throughput

0.479

High

1221785

SMC5
Structural maintenance of chromosomes protein 5

1

13

High-throughput

0.479

High

1244536

NUP43
Nucleoporin Nup43

1

8

High-throughput

0.479

High

1244731

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1267198

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1269780

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1270959

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

1288348

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

11

High-throughput

0.479

High

1294079

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

1309300

MEP50
Methylosome protein WDR77

1

8

High-throughput

0.479

High

1311553

PCGF1
Polycomb group RING finger protein 1

1

9

High-throughput

0.479

High

1313198

DDX23
Probable ATP-dependent RNA helicase DDX23

1

8

High-throughput

0.479

High

1316709

PCGF6
Polycomb group RING finger protein 6

1

12

High-throughput

0.479

High

1326758

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

1346957

NLE1
Notchless protein homolog 1

1

7

High-throughput

0.479

High

1348353

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1348691

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1348693

BAZ1B
Tyrosine-protein kinase BAZ1B

1

19

Small-scale

0.479

High

1348701

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

1348702

SRRM2
Serine/arginine repetitive matrix protein 2

1

7

High-throughput

0.479

High

1348703

TR150
Thyroid hormone receptor-associated protein 3

1

11

High-throughput

0.479

High

1068684

PLEC
Plectin

1

10

High-throughput

0.470

High

1222231

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1345438

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1347250

GPT2L
G patch domain-containing protein 2-like

1

0

High-throughput

0.458

High

1348695

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

402553

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

177098

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

9

High-throughput

0.437

High

806414

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.437

High

842700

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.437

High

943704

KRT85
Keratin, type II cuticular Hb5

1

4

High-throughput

0.437

High

1015839

TMM94
Transmembrane protein 94

1

2

High-throughput

0.437

High

1032164

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

7

High-throughput

0.437

High

1055199

K1H2
Keratin, type I cuticular Ha2

1

5

High-throughput

0.437

High

1060072

LASP1
LIM and SH3 domain protein 1

1

8

Small-scale

0.437

High

1071427

K1H1
Keratin, type I cuticular Ha1

1

5

High-throughput

0.437

High

1136329

RC3H1
Roquin-1

1

2

High-throughput

0.437

High

1146900

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.437

High

1205956

C2CD5
C2 domain-containing protein 5

1

5

High-throughput

0.437

High

1335205

RC3H2
Roquin-2

1

11

High-throughput

0.437

High

159684

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

456197

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

483503

SAA1
Serum amyloid A-1 protein

1

0

High-throughput

0.279

Low

1022777

MALL
MAL-like protein

1

0

High-throughput

0.279

Low

1231423

CT197
Putative uncharacterized protein encoded by LINC02910

1

0

High-throughput

0.279

Low

1252894

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1285616

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1288833

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1345946

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.279

Low

1348690

AHSP
Alpha-hemoglobin-stabilizing protein

1

0

High-throughput

0.279

Low

1146198

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1161794

HAGHL
Hydroxyacylglutathione hydrolase-like protein

1

0

High-throughput

0.249

Low

1317260

KRA93
Keratin-associated protein 9-3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024