Protein: EIF2A
Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]

Gene: EIF2A
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9BY44

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585545

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

6

3

Small-scale

0.725

High

738806

SPB5
Serpin B5

3

5

High-throughput

0.667

High

361917

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

1

High-throughput

0.628

High

1316093

DNAI2
Dynein axonemal intermediate chain 2

1

16

High-throughput

0.618

High

243588

DNJA2
DnaJ homolog subfamily A member 2

2

11

High-throughput

0.611

High

388906

CP1A1
Cytochrome P450 1A1

3

2

High-throughput

0.609

High

679697

FGF9
Fibroblast growth factor 9

2

0

High-throughput

0.602

High

347807

MYC
Myc proto-oncogene protein

2

13

High-throughput

0.584

High

1316098

E2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3

2

9

Small-scale

0.584

High

664126

T2EB
Transcription initiation factor IIE subunit beta

2

1

High-throughput

0.574

High

1261492

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

1

High-throughput

0.574

High

370360

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

941396

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

Small-scale

0.561

High

883732

WDR4
tRNA

1

17

Small-scale

0.553

High

1017430

CDC20
Cell division cycle protein 20 homolog

1

20

High-throughput

0.553

High

1146810

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.553

High

1244472

NUP43
Nucleoporin Nup43

1

19

High-throughput

0.553

High

1316104

FZR1
Fizzy-related protein homolog

1

18

High-throughput

0.553

High

230912

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

311751

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.536

High

337551

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.536

High

428410

TBB5
Tubulin beta chain

1

16

High-throughput

0.536

High

515934

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

574433

RL35A
Large ribosomal subunit protein eL33

1

4

High-throughput

0.536

High

681584

DNJA1
DnaJ homolog subfamily A member 1

1

11

High-throughput

0.536

High

1154459

FSTL4
Follistatin-related protein 4

1

5

High-throughput

0.536

High

1231198

KLH34
Kelch-like protein 34

1

2

High-throughput

0.536

High

1306661

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

1316092

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1316103

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.536

High

1234556

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

1316099

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.513

High

395686

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1316105

5MP1
eIF5-mimic protein 1

1

7

Small-scale

0.501

High

1314610

RBM4
RNA-binding protein 4

1

14

Small-scale

0.500

High

324009

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.489

High

735006

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

6

High-throughput

0.489

High

821398

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.489

High

943458

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.489

High

996123

HDHD1
Pseudouridine-5'-phosphatase

1

1

High-throughput

0.489

High

1069494

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.489

High

1073141

SF3B3
Splicing factor 3B subunit 3

1

8

High-throughput

0.489

High

1183112

MARK2
Serine/threonine-protein kinase MARK2

1

0

Small-scale

0.480

High

214364

SPOP
Speckle-type POZ protein

1

4

High-throughput

0.479

High

228587

PRKN
E3 ubiquitin-protein ligase parkin

1

12

High-throughput

0.479

High

323090

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

11

High-throughput

0.479

High

442461

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

12

High-throughput

0.479

High

504699

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

547200

EZRI
Ezrin

1

3

High-throughput

0.479

High

570036

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

719114

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

738017

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.479

High

742509

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

780047

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

893144

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

920322

RS24
Small ribosomal subunit protein eS24

1

4

High-throughput

0.479

High

999061

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.479

High

1019927

ILF3
Interleukin enhancer-binding factor 3

1

10

Small-scale

0.479

High

1030466

G3BP1
Ras GTPase-activating protein-binding protein 1

1

8

High-throughput

0.479

High

1053974

CAPR1
Caprin-1

1

5

High-throughput

0.479

High

1058287

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

Small-scale

0.479

High

1081394

E2F4
Transcription factor E2F4

1

4

High-throughput

0.479

High

1086159

DUS5
Dual specificity protein phosphatase 5

1

1

High-throughput

0.479

High

1087383

H2B2E
Histone H2B type 2-E

1

7

High-throughput

0.479

High

1136266

RC3H1
Roquin-1

1

4

High-throughput

0.479

High

1171564

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

1193172

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

1240962

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1254252

BICD2
Protein bicaudal D homolog 2

1

7

High-throughput

0.479

High

1267145

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1284049

LRC59
Leucine-rich repeat-containing protein 59

1

2

High-throughput

0.479

High

1309714

E2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1

1

8

Small-scale

0.479

High

1316091

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1316094

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

1316095

ANLN
Anillin

1

4

High-throughput

0.479

High

1316096

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1316100

E2AK4
eIF-2-alpha kinase GCN2

1

5

Small-scale

0.479

High

1316101

NXF1
Nuclear RNA export factor 1

1

2

Small-scale

0.479

High

1316102

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

352247

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

522170

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

579288

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.458

High

331078

PAK4
Serine/threonine-protein kinase PAK 4

1

3

High-throughput

0.445

High

497551

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

790867

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

8

High-throughput

0.445

High

1130549

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

1272329

RENT1
Regulator of nonsense transcripts 1

1

5

Small-scale

0.445

High

244892

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.437

High

328946

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

379821

MYCN
N-myc proto-oncogene protein

1

12

High-throughput

0.437

High

385472

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

553628

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

652160

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.437

High

721353

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

793655

DCC
Netrin receptor DCC

1

1

Small-scale

0.437

High

1022192

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.437

High

1029833

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.437

High

1064686

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.437

High

1080298

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.437

High

1146173

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

1188817

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

1192649

VTCN1
V-set domain-containing T-cell activation inhibitor 1

1

1

Small-scale

0.437

High

1200634

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.437

High

402436

JUN
Transcription factor Jun

1

13

High-throughput

0.407

High

1079594

NEDD8
NEDD8

1

4

Small-scale

0.407

High

1269530

ESR2
Estrogen receptor beta

1

20

High-throughput

0.407

High

831664

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.373

High

225040

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

1282308

SNX21
Sorting nexin-21

2

0

High-throughput

0.328

High

1303659

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

2

0

High-throughput

0.328

High

245741

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.279

Low

277274

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

949053

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1291632

TRM61
tRNA

1

0

High-throughput

0.279

Low

1297911

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1316097

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

776390

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.265

Low


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Last updated: 15 Jul 2024