Protein: PDE8A
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)

Gene: PDE8A
Organism: Homo sapiens
Interactions: 24
UniProt ID: O60658

Gene Ontology (top 5):
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006198 - cAMP catabolic process
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

238064

U119A
Protein unc-119 homolog A

3

1

High-throughput

0.667

High

238051

PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

1

7

High-throughput

0.665

High

238068

TRIB1
Tribbles homolog 1

1

10

High-throughput

0.536

High

238063

NR1H3
Oxysterols receptor LXR-alpha

1

0

High-throughput

0.513

High

238052

RASK
GTPase KRas

1

2

High-throughput

0.479

High

238053

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

238054

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

238055

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

Small-scale

0.479

High

238056

IKBA
NF-kappa-B inhibitor alpha

1

3

Small-scale

0.479

High

238057

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.479

High

238058

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

High-throughput

0.479

High

238059

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

6

Small-scale

0.479

High

238060

RELB
Transcription factor RelB

1

4

Small-scale

0.479

High

238061

TF65
Transcription factor p65

1

4

Small-scale

0.479

High

238062

REL
Proto-oncogene c-Rel

1

4

Small-scale

0.479

High

238065

IKBB
NF-kappa-B inhibitor beta

1

3

Small-scale

0.479

High

238067

NPHP3
Nephrocystin-3

1

1

High-throughput

0.479

High

238071

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.479

High

238072

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.479

High

238073

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

238050

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

238069

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.426

High

238070

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

238066

OCLN
Occludin

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024