Protein: ITB3
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

Gene: ITB3, Itgb3
Organism: Mus musculus
Interactions: 117
UniProt ID: O54890

Gene Ontology (top 5):
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001954 - positive regulation of cell-matrix adhesion
GO:0001968 - fibronectin binding
GO:0002020 - protease binding
GO:0003756 - protein disulfide isomerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

236544

ITB3
Integrin beta-3

1

12

High-throughput

0.647

High

236559

TLN1
Talin-1

1

20

High-throughput

0.647

High

236605

FLNB
Filamin-B

1

20

High-throughput

0.647

High

236612

FLNA
Filamin-A

1

20

High-throughput

0.647

High

236551

ITA5
Integrin alpha-5

1

20

Small-scale

0.618

High

236548

SRC
Proto-oncogene tyrosine-protein kinase Src

2

11

Small-scale

0.584

High

236624

FLNC
Filamin-C

1

20

High-throughput

0.579

High

236563

ITAV
Integrin alpha-V

1

20

Small-scale

0.575

High

236568

KPCB
Protein kinase C beta type

1

13

Small-scale

0.515

High

59673

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.501

High

59697

A2ANY6
Midasin

1

9

High-throughput

0.501

High

98318

E9QKZ2
Importin 9

1

6

High-throughput

0.501

High

98335

E9QLK7
Transformation/transcription domain-associated protein

1

3

High-throughput

0.501

High

107473

F8WIE5
E3 ubiquitin-protein ligase

1

9

High-throughput

0.501

High

108356

G3X9H5
Huntingtin

1

2

High-throughput

0.501

High

148352

DIAP1
Protein diaphanous homolog 1

1

3

High-throughput

0.501

High

148773

MA2B1
Lysosomal alpha-mannosidase

1

5

High-throughput

0.501

High

236545

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.501

High

236546

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

1

High-throughput

0.501

High

236547

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

2

High-throughput

0.501

High

236549

ENPL
Endoplasmin

1

1

High-throughput

0.501

High

236550

NUCL
Nucleolin

1

1

High-throughput

0.501

High

236552

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.501

High

236556

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.501

High

236557

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

10

High-throughput

0.501

High

236558

MOV10
Putative helicase MOV-10

1

8

High-throughput

0.501

High

236566

HS74L
Heat shock 70 kDa protein 4L

1

4

High-throughput

0.501

High

236567

MCM4
DNA replication licensing factor MCM4

1

5

High-throughput

0.501

High

236569

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

5

High-throughput

0.501

High

236570

TP53B
TP53-binding protein 1

1

7

High-throughput

0.501

High

236571

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.501

High

236572

MCM6
DNA replication licensing factor MCM6

1

5

High-throughput

0.501

High

236573

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.501

High

236575

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

High-throughput

0.501

High

236576

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.501

High

236577

PSA
Puromycin-sensitive aminopeptidase

1

2

High-throughput

0.501

High

236581

ESYT1
Extended synaptotagmin-1

1

2

High-throughput

0.501

High

236582

PUR4
Phosphoribosylformylglycinamidine synthase

1

1

High-throughput

0.501

High

236584

HCFC1
Host cell factor 1

1

8

High-throughput

0.501

High

236585

EWS
RNA-binding protein EWS

1

4

High-throughput

0.501

High

236586

HS105
Heat shock protein 105 kDa

1

4

High-throughput

0.501

High

236588

MYH10
Myosin-10

1

5

High-throughput

0.501

High

236590

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.501

High

236592

VINC
Vinculin

1

12

High-throughput

0.501

High

236594

MYOF
Myoferlin

1

5

High-throughput

0.501

High

236595

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.501

High

236597

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

1

High-throughput

0.501

High

236599

XPO1
Exportin-1

1

3

High-throughput

0.501

High

236600

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.501

High

236601

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.501

High

236603

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

High-throughput

0.501

High

236607

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.501

High

236608

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.501

High

236610

IPO5
Importin-5

1

1

High-throughput

0.501

High

236611

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.501

High

236613

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.501

High

236616

SMC2
Structural maintenance of chromosomes protein 2

1

7

High-throughput

0.501

High

236618

IPO11
Importin-11

1

7

High-throughput

0.501

High

236619

SF3A1
Splicing factor 3A subunit 1

1

4

High-throughput

0.501

High

236621

MYH9
Myosin-9

1

5

High-throughput

0.501

High

236623

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.501

High

236627

MA2C1
Alpha-mannosidase 2C1

1

5

High-throughput

0.501

High

236631

OGFR
Opioid growth factor receptor

1

3

High-throughput

0.501

High

236632

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.501

High

236634

IPO7
Importin-7

1

6

High-throughput

0.501

High

236635

RENT1
Regulator of nonsense transcripts 1

1

8

High-throughput

0.501

High

236636

XPO2
Exportin-2

1

7

High-throughput

0.501

High

236639

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

1

High-throughput

0.501

High

236641

PLEC
Plectin

1

13

High-throughput

0.501

High

236642

UBQL2
Ubiquilin-2

1

1

Small-scale

0.501

High

236643

VAV3
Guanine nucleotide exchange factor VAV3

1

2

High-throughput

0.501

High

236644

PDC6I
Programmed cell death 6-interacting protein

1

3

High-throughput

0.501

High

236583

CAPR1
Caprin-1

1

0

High-throughput

0.480

High

236593

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.480

High

236604

TCPR1
Tectonin beta-propeller repeat-containing protein 1

1

0

High-throughput

0.480

High

236625

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.480

High

236633

DNSL2
Deoxyribonuclease-1-like 2

1

0

High-throughput

0.480

High

236647

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.480

High

236554

KPCA
Protein kinase C alpha type

1

13

Small-scale

0.479

High

236555

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

1

High-throughput

0.479

High

236562

CSK
Tyrosine-protein kinase CSK

1

12

Small-scale

0.479

High

236565

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

236574

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.479

High

236564

PA24A
Cytosolic phospholipase A2

1

6

Small-scale

0.470

High

86330

B9EKJ1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.457

High

104745

TPR
Nucleoprotein TPR

1

8

High-throughput

0.457

High

205307

AP1B1
AP-1 complex subunit beta-1

1

2

High-throughput

0.457

High

236553

AP2A2
AP-2 complex subunit alpha-2

1

1

High-throughput

0.457

High

236560

UBA1Y
Ubiquitin-like modifier-activating enzyme 1 Y

1

2

High-throughput

0.457

High

236578

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.457

High

236579

Q3U2G2
Heat shock 70 kDa protein 4

1

3

High-throughput

0.457

High

236580

SC24A
Protein transport protein Sec24A

1

1

High-throughput

0.457

High

236587

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.457

High

236591

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

4

High-throughput

0.457

High

236596

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.457

High

236598

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

2

High-throughput

0.457

High

236602

ATX2L
Ataxin-2-like protein

1

3

High-throughput

0.457

High

236606

Q80X98
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

1

High-throughput

0.457

High

236609

Q8BIX2
GCN1 activator of EIF2AK4

1

6

High-throughput

0.457

High

236620

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.457

High

236622

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.457

High

236626

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

High-throughput

0.457

High

236628

Q921K2
Poly [ADP-ribose] polymerase

1

1

High-throughput

0.457

High

236629

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.457

High

236630

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

2

High-throughput

0.457

High

236637

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

5

High-throughput

0.457

High

236638

COPB
Coatomer subunit beta

1

2

High-throughput

0.457

High

236640

SON
Protein SON

1

8

High-throughput

0.457

High

236645

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

236646

SYVC
Valine--tRNA ligase

1

4

High-throughput

0.457

High

236589

KPCD1
Serine/threonine-protein kinase D1

1

13

Small-scale

0.445

High

97703

E9PWG6
Non-SMC condensin I complex, subunit G

1

0

High-throughput

0.261

Low

236561

DYN2
Dynamin-2

1

0

High-throughput

0.261

Low

236614

Q8C1W8
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

236615

Q8C839
Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein

1

0

High-throughput

0.261

Low

236617

COPA
Coatomer subunit alpha

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025