Protein: DLDH
Dihydrolipoyl dehydrogenase, mitochondrial (DLD) (EC 1.8.1.4) (2-oxoglutarate dehydrogenase complex component E3) (OGDC-E3) (OGDHC subunit E3) (Alpha-ketoglutarate dehydrogenase complex subunit E3) (alpha-KGDHC subunit E3) (Dihydrolipoamide dehydrogenase) (Dihydrolipoamide:NAD(+) oxidoreductase) (Glycine decarboxylase complex subunit L) (GDC subunit L) (Lipoamide dehydrogenase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex E3 component) (PDC subunit E3) (PDH complex subunit E3)

Gene: DLDH, LPD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P09624

Gene Ontology (top 5):
GO:0004148 - dihydrolipoyl dehydrogenase activity
GO:0004375 - glycine dehydrogenase (decarboxylating) activity
GO:0004591 - oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0004738 - pyruvate dehydrogenase activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452941

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

12

High-throughput

0.754

High

452951

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

7

12

Small-scale

0.748

High

452953

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

5

7

Small-scale

0.716

High

452975

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

4

3

High-throughput

0.691

High

452952

KGD4
Alpha-ketoglutarate dehydrogenase subunit 4, mitochondrial

5

0

Small-scale

0.686

High

452948

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

3

13

High-throughput

0.656

High

452981

PREP
Presequence protease, mitochondrial

3

0

High-throughput

0.634

High

453008

ETFB
Probable electron transfer flavoprotein subunit beta

1

1

High-throughput

0.618

High

453023

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

1

High-throughput

0.618

High

453037

ETFA
Probable electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.618

High

452965

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

2

0

High-throughput

0.592

High

452937

HSP77
Import motor subunit, mitochondrial

2

1

High-throughput

0.584

High

452947

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

2

4

High-throughput

0.584

High

452939

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

452940

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.549

High

452971

HS104
Heat shock protein 104

2

2

Small-scale

0.521

High

452998

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

0

High-throughput

0.513

High

452938

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.504

High

453001

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.504

High

389609

DNLI1
DNA ligase 1

1

1

High-throughput

0.500

High

452963

CDC10
Cell division control protein 10

1

2

High-throughput

0.489

High

452997

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.489

High

452978

TOR2
Serine/threonine-protein kinase TOR2

1

2

High-throughput

0.481

High

393877

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.479

High

452955

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.479

High

452960

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.479

High

452992

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.479

High

453026

POLH
DNA polymerase eta

1

0

High-throughput

0.479

High

452950

MDHM
Malate dehydrogenase, mitochondrial

1

4

Small-scale

0.479

High

452956

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.479

High

452966

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

2

High-throughput

0.479

High

452967

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

452973

ACPM
Acyl carrier protein, mitochondrial

1

1

High-throughput

0.479

High

452984

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

452989

LAS1
Protein LAS1

1

1

Small-scale

0.479

High

452999

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

453022

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

341889

ATPB
ATP synthase subunit beta, mitochondrial

1

0

High-throughput

0.458

High

375216

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

423557

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

452954

CBP3
Protein CBP3, mitochondrial

1

0

High-throughput

0.458

High

452957

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

452959

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

452964

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

452980

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

452988

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

452993

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

452996

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

453000

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

0

High-throughput

0.458

High

453006

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

453010

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

453012

ALAM
Probable alanine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

453017

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

453018

SHY1
Cytochrome oxidase assembly protein SHY1

1

0

Small-scale

0.458

High

453025

DML1
Protein DML1

1

0

High-throughput

0.458

High

453030

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

453033

YL419
Putative ATP-dependent RNA helicase YLR419W

1

0

High-throughput

0.458

High

452936

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

7

High-throughput

0.457

High

434721

PBS2
MAP kinase kinase PBS2

1

2

High-throughput

0.457

High

452942

SRS2
ATP-dependent DNA helicase SRS2

1

2

High-throughput

0.457

High

452970

RAD16
DNA repair protein RAD16

1

3

High-throughput

0.457

High

452974

CDC12
Cell division control protein 12

1

2

High-throughput

0.457

High

452977

PP12
Serine/threonine-protein phosphatase PP1-2

1

2

High-throughput

0.457

High

452979

RAD54
DNA repair and recombination protein RAD54

1

2

High-throughput

0.457

High

452995

TEM1
Protein TEM1

1

3

High-throughput

0.457

High

453003

RAD26
DNA repair and recombination protein RAD26

1

2

High-throughput

0.457

High

453014

PPT1
Serine/threonine-protein phosphatase T

1

3

High-throughput

0.457

High

453015

BOL2
BolA-like protein 2

1

3

High-throughput

0.457

High

453020

IPI3
Pre-rRNA-processing protein IPI3

1

2

High-throughput

0.457

High

453021

NOP13
Nucleolar protein 13

1

2

High-throughput

0.457

High

453027

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.457

High

453035

DNLI4
DNA ligase 4

1

1

High-throughput

0.457

High

452986

TOR1
Serine/threonine-protein kinase TOR1

1

2

High-throughput

0.439

High

402844

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.437

High

452946

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.437

High

452961

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

452969

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

452991

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

453024

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

453038

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.437

High

367636

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

365616

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.407

High

452949

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.407

High

452976

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.407

High

452994

BZZ1
Protein BZZ1

1

0

High-throughput

0.282

High

431327

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.279

Low

452990

TAF5
Transcription initiation factor TFIID subunit 5

1

0

High-throughput

0.279

Low

453013

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.279

Low

420531

SPT2
Protein SPT2

1

0

High-throughput

0.261

Low

452944

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.261

Low

452945

ABP1
Actin-binding protein

1

0

High-throughput

0.261

Low

452958

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

452962

RAD57
DNA repair protein RAD57

1

0

High-throughput

0.261

Low

452968

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.261

Low

452972

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.261

Low

453002

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.261

Low

453004

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

453005

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.261

Low

453011

RL37B
Large ribosomal subunit protein eL37B

1

0

High-throughput

0.261

Low

453016

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.261

Low

453019

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.261

Low

453029

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

453034

RBX1
RING-box protein HRT1

1

0

High-throughput

0.261

Low

453036

YP150
Putative serine/threonine-protein kinase YPL150W

1

0

High-throughput

0.261

Low

252681

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

452943

CPYI
Carboxypeptidase Y inhibitor

1

0

Small-scale

0.249

Low

452982

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

452983

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

452985

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.249

Low

452987

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.249

Low

453009

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

453032

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

453007

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

453028

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.232

Low

453031

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024