Protein: DEN2B
DENN domain-containing protein 2B (HeLa tumor suppression 1) (Suppression of tumorigenicity 5 protein)

Gene: DEN2B, DENND2B
Organism: Homo sapiens
Interactions: 24
UniProt ID: P78524

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005886 - plasma membrane
GO:0005938 - cell cortex
GO:0055037 - recycling endosome
GO:0070374 - positive regulation of ERK1 and ERK2 cascade

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

904438

1433G
14-3-3 protein gamma

3

20

High-throughput

0.609

High

909436

1433E
14-3-3 protein epsilon

2

5

High-throughput

0.580

High

926916

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.558

High

944172

1433F
14-3-3 protein eta

1

20

High-throughput

0.554

High

683957

1433S
14-3-3 protein sigma

2

20

High-throughput

0.549

High

944176

L2GL2
LLGL scribble cell polarity complex component 2

1

3

High-throughput

0.536

High

944179

ANLN
Anillin

1

4

High-throughput

0.536

High

337428

ABL1
Tyrosine-protein kinase ABL1

1

9

Small-scale

0.527

High

724770

MYH9
Myosin-9

1

0

High-throughput

0.513

High

646791

1433T
14-3-3 protein theta

1

20

High-throughput

0.506

High

433320

YES
Tyrosine-protein kinase Yes

1

8

High-throughput

0.501

High

906411

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.489

High

944177

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.489

High

944178

MYO19
Unconventional myosin-XIX

1

4

High-throughput

0.489

High

924471

GRB2
Growth factor receptor-bound protein 2

1

10

Small-scale

0.479

High

432651

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.470

High

281600

WFS1
Wolframin

1

1

High-throughput

0.470

High

944175

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.464

High

346496

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

683260

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.437

High

944173

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.437

High

944174

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.437

High

717686

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.407

High

791480

HD
Huntingtin

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024