Protein: PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]

Gene: PUR92, ADE17
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: P38009

Gene Ontology (top 5):
GO:0003937 - IMP cyclohydrolase activity
GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006164 - purine nucleotide biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

742733

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

5

3

High-throughput

0.918

High

742711

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

2

3

High-throughput

0.785

High

742726

SOL1
6-phosphogluconolactonase-like protein 1

3

3

High-throughput

0.666

High

742722

SA155
SIT4-associating protein SAP155

2

0

High-throughput

0.587

High

742714

RSP5
E3 ubiquitin-protein ligase RSP5

2

0

Small-scale

0.577

High

696305

PP12
Serine/threonine-protein phosphatase PP1-2

2

1

High-throughput

0.558

High

705076

HSP78
Heat shock protein 78, mitochondrial

2

2

High-throughput

0.521

High

294116

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.518

High

682279

ACBP
Acyl-CoA-binding protein

1

0

High-throughput

0.518

High

687356

EF2
Elongation factor 2

1

0

High-throughput

0.518

High

704508

SNC2
Synaptobrevin homolog 2

1

0

High-throughput

0.518

High

739483

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.518

High

742719

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

0

High-throughput

0.518

High

742729

HCH1
Hsp90 co-chaperone HCH1

1

0

High-throughput

0.518

High

742731

SYC
Cysteine--tRNA ligase

1

0

High-throughput

0.518

High

742745

PST2
Protoplast secreted protein 2

1

0

High-throughput

0.518

High

579416

GBB
Guanine nucleotide-binding protein subunit beta

1

0

High-throughput

0.513

High

409636

KAPC
cAMP-dependent protein kinase type 3

1

2

High-throughput

0.501

High

412971

KAPB
cAMP-dependent protein kinase type 2

1

1

High-throughput

0.501

High

696783

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.494

High

742730

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.494

High

586393

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

526220

KIN2
Serine/threonine-protein kinase KIN2

1

0

High-throughput

0.480

High

742721

BNI1
Protein BNI1

1

0

High-throughput

0.480

High

742725

ENT3
Epsin-3

1

0

Small-scale

0.480

High

366147

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

543579

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

627937

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

740822

SOL2
6-phosphogluconolactonase-like protein 2

1

3

High-throughput

0.479

High

742712

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

742728

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

562703

FUS3
Mitogen-activated protein kinase FUS3

1

2

High-throughput

0.457

High

550012

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.457

High

584714

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.457

High

707332

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.457

High

490952

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

493732

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

510992

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

694523

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

695945

HSP79
Heat shock protein homolog SSE2

1

4

High-throughput

0.445

High

742715

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

685410

MLF3
Protein MLF3

1

0

High-throughput

0.438

High

742724

YJ66
Uncharacterized oxidoreductase YJR096W

1

0

High-throughput

0.438

High

661979

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

691025

HOG1
Mitogen-activated protein kinase HOG1

1

1

High-throughput

0.437

High

742738

TAF7
Transcription initiation factor TFIID subunit 7

1

1

High-throughput

0.437

High

633147

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

742742

RIX7
Ribosome biogenesis ATPase RIX7

1

1

High-throughput

0.407

High

516971

INO1
Inositol-3-phosphate synthase

2

0

High-throughput

0.319

High

742734

ALO
D-arabinono-1,4-lactone oxidase

2

0

High-throughput

0.319

High

524264

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.282

High

587910

PNPP
4-nitrophenylphosphatase

1

0

High-throughput

0.282

High

648310

GYS2
Glycogen [starch] synthase isoform 2

1

0

High-throughput

0.282

High

728223

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.282

High

742737

SKI8
Antiviral protein SKI8

1

0

High-throughput

0.282

High

742739

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.282

High

742747

HUG1
MEC1-mediated checkpoint protein HUG1

1

0

High-throughput

0.282

High

742716

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

742727

PDK2
[Pyruvate dehydrogenase

1

0

High-throughput

0.261

Low

742740

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.261

Low

742723

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

742736

RMI1
RecQ-mediated genome instability protein 1

1

0

High-throughput

0.249

Low

742741

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

742743

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

742746

LAS17
Proline-rich protein LAS17

1

0

Small-scale

0.249

Low

742713

ATC2
Calcium-transporting ATPase 2

1

0

High-throughput

0.238

Low

742720

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.238

Low

742735

RAGAB
GTP-binding protein GTR1

1

0

High-throughput

0.238

Low

742744

FLC1
Flavin carrier protein 1

1

0

High-throughput

0.238

Low

742717

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

742718

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

742732

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024