Protein: RAD50
DNA repair protein RAD50 (EC 3.6.-.-) (153 kDa protein)

Gene: RAD50
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P12753

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000722 - telomere maintenance via recombination
GO:0000794 - condensed nuclear chromosome
GO:0003690 - double-stranded DNA binding
GO:0003691 - double-stranded telomeric DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

521122

MRE11
Double-strand break repair protein MRE11

35

6

Small-scale

0.995

High

521101

RAD50
DNA repair protein RAD50

2

17

Small-scale

0.781

High

521126

XRS2
DNA repair protein XRS2

11

0

Small-scale

0.723

High

521129

ATM
Serine/threonine-protein kinase TEL1

4

13

Small-scale

0.694

High

521157

RIF2
Protein RIF2

4

0

Small-scale

0.668

High

521145

COM1
DNA endonuclease SAE2

4

0

Small-scale

0.661

High

521124

SMC1
Structural maintenance of chromosomes protein 1

1

17

High-throughput

0.656

High

521163

SMC6
Structural maintenance of chromosomes protein 6

1

18

High-throughput

0.618

High

521125

PRS6B
26S proteasome regulatory subunit 6B homolog

2

0

High-throughput

0.602

High

521128

PP2C3
Protein phosphatase 2C homolog 3

2

0

High-throughput

0.595

High

449877

HSP73
Heat shock protein SSA3

2

8

High-throughput

0.588

High

521135

HSP7E
Heat shock protein SSC3, mitochondrial

2

8

High-throughput

0.588

High

365681

HSP82
ATP-dependent molecular chaperone HSP82

2

7

High-throughput

0.584

High

521115

MAS5
Mitochondrial protein import protein MAS5

2

5

High-throughput

0.584

High

521146

NNF1
Kinetochore-associated protein NNF1

2

0

High-throughput

0.570

High

521160

RPN8
26S proteasome regulatory subunit RPN8

2

2

High-throughput

0.558

High

521102

YAK1
Dual specificity protein kinase YAK1

1

20

High-throughput

0.536

High

521107

VATA
V-type proton ATPase catalytic subunit A

1

4

High-throughput

0.536

High

521114

SSK22
Serine/threonine-protein kinase SSK22

1

11

High-throughput

0.536

High

521131

DUN1
DNA damage response protein kinase DUN1

1

16

High-throughput

0.536

High

521140

MAM33
Mitochondrial acidic protein MAM33

1

1

High-throughput

0.536

High

521144

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

6

High-throughput

0.536

High

521153

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.536

High

521110

RFA1
Replication factor A protein 1

1

6

Small-scale

0.527

High

334417

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.515

High

485623

IF4A
ATP-dependent RNA helicase eIF4A

1

3

High-throughput

0.515

High

521105

EF3A
Elongation factor 3A

1

1

High-throughput

0.515

High

521162

NOP56
Nucleolar protein 56

1

1

High-throughput

0.515

High

521108

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.513

High

521136

IES5
Ino eighty subunit 5

1

0

High-throughput

0.513

High

521142

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.513

High

521150

ORN
Oligoribonuclease, mitochondrial

1

0

High-throughput

0.513

High

521127

NUF2
Kinetochore protein NUF2

1

5

High-throughput

0.508

High

341897

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.500

High

521103

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.500

High

521104

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.500

High

521112

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.493

High

521130

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.493

High

521121

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.489

High

521143

COPB2
Coatomer subunit beta'

1

5

High-throughput

0.489

High

345224

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

1

0

High-throughput

0.486

High

521156

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.486

High

521158

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.486

High

521109

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.481

High

521116

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.481

High

381411

GAL1
Galactokinase

1

0

High-throughput

0.479

High

397568

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.479

High

421561

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.479

High

520892

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

521139

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.479

High

521117

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

521148

PRS10
26S proteasome subunit RPT4

1

3

High-throughput

0.479

High

521149

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.479

High

521151

CDC14
Tyrosine-protein phosphatase CDC14

1

12

Small-scale

0.479

High

521152

CTF4
DNA polymerase alpha-binding protein

1

8

High-throughput

0.479

High

521155

PDS5
Sister chromatid cohesion protein PDS5

1

9

High-throughput

0.479

High

521118

EF2
Elongation factor 2

1

5

High-throughput

0.470

High

521132

END3
Actin cytoskeleton-regulatory complex protein END3

1

3

High-throughput

0.464

High

521147

SP105
Spindle pole body component SPC105

1

0

High-throughput

0.460

High

333584

CYB2
L-lactate dehydrogenase

1

0

High-throughput

0.458

High

521106

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

521154

DIG2
Down-regulator of invasive growth 2

1

0

High-throughput

0.458

High

490162

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

493049

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

510072

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

521113

SIS1
Protein SIS1

1

4

High-throughput

0.445

High

521119

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

521120

HSP79
Heat shock protein homolog SSE2

1

11

High-throughput

0.445

High

521133

TCPD
T-complex protein 1 subunit delta

1

6

High-throughput

0.445

High

521134

XDJ1
DnaJ protein homolog XDJ1

1

5

High-throughput

0.445

High

521137

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

521141

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.445

High

521123

SSO1
Protein SSO1

1

3

High-throughput

0.439

High

416749

CDC31
Cell division control protein 31

1

2

Small-scale

0.437

High

521164

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

521161

SMT3
Ubiquitin-like protein SMT3

1

3

Small-scale

0.408

High

417555

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.279

Low

381674

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

521111

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.249

Low

521159

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

521138

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024