Protein: ATG12
Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like)

Gene: ATG12
Organism: Homo sapiens
Interactions: 121
UniProt ID: O94817

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000421 - autophagosome membrane
GO:0000422 - autophagy of mitochondrion
GO:0005654 - nucleoplasm
GO:0005776 - autophagosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317677

ATG5
Autophagy protein 5

11

3

Small-scale

0.975

High

317685

ATG3
Ubiquitin-like-conjugating enzyme ATG3

14

6

Small-scale

0.761

High

317649

A16L1
Autophagy-related protein 16-1

9

1

Small-scale

0.755

High

317676

ATG10
Ubiquitin-like-conjugating enzyme ATG10

5

6

Small-scale

0.714

High

317657

RBCC1
RB1-inducible coiled-coil protein 1

4

1

Small-scale

0.701

High

317653

TCPR1
Tectonin beta-propeller repeat-containing protein 1

4

0

Small-scale

0.664

High

317599

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

3

3

Small-scale

0.664

High

317698

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

2

1

Small-scale

0.584

High

317638

SRTD2
SERTA domain-containing protein 2

2

0

High-throughput

0.580

High

317670

IER2
Immediate early response gene 2 protein

2

0

High-throughput

0.580

High

317620

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

Small-scale

0.537

High

300611

KRT37
Keratin, type I cuticular Ha7

1

2

High-throughput

0.536

High

317598

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.536

High

317633

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

1

High-throughput

0.536

High

317637

RB33A
Ras-related protein Rab-33A

1

2

High-throughput

0.536

High

317675

RB33B
Ras-related protein Rab-33B

1

2

High-throughput

0.536

High

180457

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

317667

KR412
Keratin-associated protein 4-12

1

0

High-throughput

0.518

High

317673

DOCK9
Dedicator of cytokinesis protein 9

1

0

High-throughput

0.518

High

317611

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.513

High

317615

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.513

High

317622

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

317625

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

317627

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.513

High

317658

CCD12
Coiled-coil domain-containing protein 12

1

0

High-throughput

0.513

High

317661

EXOC4
Exocyst complex component 4

1

0

Small-scale

0.513

High

317697

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

317600

RIGI
Antiviral innate immune response receptor RIG-I

1

1

Small-scale

0.500

High

317672

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

1

Small-scale

0.500

High

285750

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.493

High

317628

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.493

High

317644

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.493

High

317655

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

Small-scale

0.493

High

317679

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

0

High-throughput

0.493

High

317701

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.493

High

317630

FAK1
Focal adhesion kinase 1

1

1

High-throughput

0.481

High

317601

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

317608

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

Small-scale

0.480

High

169363

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

High-throughput

0.479

High

172346

XPO1
Exportin-1

1

2

High-throughput

0.479

High

279085

ULK1
Serine/threonine-protein kinase ULK1

1

1

Small-scale

0.479

High

317603

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

317605

BCL2
Apoptosis regulator Bcl-2

1

1

Small-scale

0.479

High

317610

LMNB1
Lamin-B1

1

1

High-throughput

0.479

High

317612

DDX6
Probable ATP-dependent RNA helicase DDX6

1

1

High-throughput

0.479

High

317618

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

2

High-throughput

0.479

High

317626

RL11
Large ribosomal subunit protein uL5

1

1

High-throughput

0.479

High

317631

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

Small-scale

0.479

High

317634

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

1

High-throughput

0.479

High

317635

FADD
FAS-associated death domain protein

1

1

Small-scale

0.479

High

317636

GOGA4
Golgin subfamily A member 4

1

1

High-throughput

0.479

High

317639

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

High-throughput

0.479

High

317642

GOGB1
Golgin subfamily B member 1

1

1

High-throughput

0.479

High

317643

K1H1
Keratin, type I cuticular Ha1

1

2

High-throughput

0.479

High

317646

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.479

High

317654

GCC2
GRIP and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

317665

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.479

High

317674

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

317687

GGA3
ADP-ribosylation factor-binding protein GGA3

1

1

High-throughput

0.479

High

317693

SNX6
Sorting nexin-6

1

1

High-throughput

0.479

High

317700

SNX5
Sorting nexin-5

1

1

High-throughput

0.479

High

317650

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

123956

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.458

High

188632

BIRC5
Baculoviral IAP repeat-containing protein 5

1

0

Small-scale

0.458

High

271388

ATG13
Autophagy-related protein 13

1

0

Small-scale

0.458

High

277869

SH3L1
Adapter SH3BGRL

1

0

Small-scale

0.458

High

294903

POP7
Ribonuclease P protein subunit p20

1

0

High-throughput

0.458

High

295436

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

0

Small-scale

0.458

High

317604

RU2B
U2 small nuclear ribonucleoprotein B''

1

0

High-throughput

0.458

High

317609

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

317621

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

317623

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

317624

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

317629

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

317632

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

High-throughput

0.458

High

317640

FLOT2
Flotillin-2

1

0

High-throughput

0.458

High

317656

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

317660

ESR2
Estrogen receptor beta

1

0

Small-scale

0.458

High

317663

VP13A
Intermembrane lipid transfer protein VPS13A

1

0

High-throughput

0.458

High

317664

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

317669

ATGA1
Autophagy-related protein 101

1

0

Small-scale

0.458

High

317671

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

1

0

High-throughput

0.458

High

317681

MOV10
Helicase MOV-10

1

0

High-throughput

0.458

High

317682

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.458

High

317683

KRT82
Keratin, type II cuticular Hb2

1

0

High-throughput

0.458

High

317688

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.458

High

317689

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.458

High

317695

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

317696

CHTOP
Chromatin target of PRMT1 protein

1

0

High-throughput

0.458

High

317617

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

317602

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.437

High

317692

XPO7
Exportin-7

1

2

High-throughput

0.437

High

317699

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.437

High

317614

HD
Huntingtin

1

0

Small-scale

0.426

High

317641

BECN1
Beclin-1

1

0

High-throughput

0.426

High

317648

Q5VVC8
Large ribosomal subunit protein uL5

1

1

High-throughput

0.407

High

317691

SRTD1
SERTA domain-containing protein 1

2

0

High-throughput

0.316

High

317652

MAVS
Mitochondrial antiviral-signaling protein

2

0

Small-scale

0.310

High

209930

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.299

High

317666

MDFI
MyoD family inhibitor

1

0

High-throughput

0.282

High

215470

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.279

Low

317668

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.279

Low

178691

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.249

Low

215368

TPD54
Tumor protein D54

1

0

High-throughput

0.249

Low

299893

CBPD
Carboxypeptidase D

1

0

High-throughput

0.249

Low

317607

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.249

Low

317613

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

317616

NUMB
Protein numb homolog

1

0

High-throughput

0.249

Low

317619

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.249

Low

317645

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.249

Low

317647

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

0

High-throughput

0.249

Low

317651

EBLN2
Endogenous Bornavirus-like nucleoprotein 2

1

0

High-throughput

0.249

Low

317659

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.249

Low

317662

Q96F87
TOG domain-containing protein

1

0

High-throughput

0.249

Low

317678

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.249

Low

317680

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.249

Low

317684

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

317686

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

317690

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.249

Low

317694

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.249

Low

317606

RALB
Ras-related protein Ral-B

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025