Protein: MCM4
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)

Gene: MCM4
Organism: Saccharomyces cerevisiae S288C
Interactions: 126
UniProt ID: P30665

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

675563

CDC45
Cell division control protein 45

26

16

Small-scale

0.990

High

667549

MCM2
DNA replication licensing factor MCM2

22

20

Small-scale

0.990

High

675537

MCM6
DNA replication licensing factor MCM6

20

20

Small-scale

0.986

High

675523

MCM7
DNA replication licensing factor MCM7

19

19

Small-scale

0.985

High

622147

MCM3
DNA replication licensing factor MCM3

18

20

Small-scale

0.984

High

667834

MCM5
Minichromosome maintenance protein 5

16

19

Small-scale

0.980

High

675576

PSF1
DNA replication complex GINS protein PSF1

14

12

Small-scale

0.979

High

675553

SLD5
DNA replication complex GINS protein SLD5

13

15

Small-scale

0.979

High

675529

PSF2
DNA replication complex GINS protein PSF2

10

11

Small-scale

0.972

High

675571

PSF3
DNA replication complex GINS protein PSF3

9

10

Small-scale

0.965

High

675531

CDT1
Cell division cycle protein CDT1

6

4

Small-scale

0.943

High

675548

CTF4
DNA polymerase alpha-binding protein

17

10

Small-scale

0.763

High

412532

CDC7
Cell division control protein 7

10

20

Small-scale

0.755

High

675509

MCM10
Minichromosome maintenance protein 10

9

14

Small-scale

0.755

High

526829

DPOLA
DNA polymerase alpha catalytic subunit A

9

12

Small-scale

0.751

High

675560

CSM3
Chromosome segregation in meiosis protein 3

9

4

Small-scale

0.748

High

675559

POB3
FACT complex subunit POB3

7

10

Small-scale

0.741

High

634863

MRC1
Mediator of replication checkpoint protein 1

7

4

Small-scale

0.740

High

675539

SLD3
DNA replication regulator SLD3

4

4

Small-scale

0.688

High

602323

DPOE
DNA polymerase epsilon catalytic subunit A

4

12

Small-scale

0.680

High

356306

H4
Histone H4

4

8

Small-scale

0.676

High

675512

SPT16
FACT complex subunit SPT16

4

6

Small-scale

0.676

High

675541

TOF1
Topoisomerase 1-associated factor 1

3

9

Small-scale

0.640

High

675545

H3
Histone H3

3

20

Small-scale

0.640

High

675517

SLD2
DNA replication regulator SLD2

2

4

Small-scale

0.595

High

675508

DBF4
DDK kinase regulatory subunit DBF4

2

4

Small-scale

0.585

High

355384

H2B1
Histone H2B.1

2

20

Small-scale

0.584

High

388089

TOP1
DNA topoisomerase 1

2

6

Small-scale

0.584

High

392075

H2A1
Histone H2A.1

2

20

Small-scale

0.584

High

392336

H2A2
Histone H2A.2

2

20

Small-scale

0.584

High

622864

DPB2
DNA polymerase epsilon subunit B

2

4

Small-scale

0.584

High

675505

MCM4
DNA replication licensing factor MCM4

1

19

Small-scale

0.575

High

340059

KPYK1
Pyruvate kinase 1

2

6

High-throughput

0.571

High

493397

HSP72
Heat shock protein SSA2

2

17

High-throughput

0.571

High

510530

SSB1
Ribosome-associated molecular chaperone SSB1

2

19

High-throughput

0.571

High

675507

HS104
Heat shock protein 104

2

6

High-throughput

0.571

High

675530

MPG1
Mannose-1-phosphate guanyltransferase

2

3

High-throughput

0.571

High

675527

SSB2
Ribosome-associated molecular chaperone SSB2

2

19

High-throughput

0.552

High

488485

PRI1
DNA primase small subunit

1

1

Small-scale

0.536

High

675506

XPO1
Exportin-1

1

4

High-throughput

0.536

High

675510

ARP2
Actin-related protein 2

1

8

High-throughput

0.536

High

675533

MRK1
Serine/threonine-protein kinase MRK1

1

7

High-throughput

0.536

High

675573

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

608450

SAN1
Protein SAN1

1

0

High-throughput

0.513

High

412681

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.501

High

565493

PHO85
Cyclin-dependent protein kinase PHO85

1

9

High-throughput

0.501

High

614570

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

675513

IME2
Meiosis induction protein kinase IME2/SME1

1

14

Small-scale

0.501

High

675538

ATG1
Serine/threonine-protein kinase ATG1

1

4

High-throughput

0.501

High

675544

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.501

High

675554

SKY1
Serine/threonine-protein kinase SKY1

1

12

High-throughput

0.501

High

675570

RTK1
Probable serine/threonine-protein kinase RTK1

1

12

High-throughput

0.501

High

675542

IPI3
Pre-rRNA-processing protein IPI3

1

3

Small-scale

0.481

High

333720

ADH1
Alcohol dehydrogenase 1

1

3

High-throughput

0.479

High

340632

PGK
Phosphoglycerate kinase

1

3

High-throughput

0.479

High

355817

H2B2
Histone H2B.2

1

20

Small-scale

0.479

High

406861

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

407783

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

410940

PDC1
Pyruvate decarboxylase isozyme 1

1

4

High-throughput

0.479

High

419603

RAD52
DNA repair and recombination protein RAD52

1

1

Small-scale

0.479

High

482133

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

543344

HSC82
ATP-dependent molecular chaperone HSC82

1

12

High-throughput

0.479

High

560922

EF3A
Elongation factor 3A

1

7

High-throughput

0.479

High

562340

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

5

High-throughput

0.479

High

605936

RAD53
Serine/threonine-protein kinase RAD53

1

8

Small-scale

0.479

High

619124

SPT6
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

638665

SPB4
ATP-dependent rRNA helicase SPB4

1

6

High-throughput

0.479

High

644737

RFA2
Replication factor A protein 2

1

5

High-throughput

0.479

High

644843

RS5
Small ribosomal subunit protein uS7

1

3

High-throughput

0.479

High

646632

DPB3
DNA polymerase epsilon subunit C

1

1

Small-scale

0.479

High

650242

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

661554

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

675511

HOG1
Mitogen-activated protein kinase HOG1

1

7

Small-scale

0.479

High

675514

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

675518

SPT10
Protein SPT10

1

4

High-throughput

0.479

High

675519

DEF1
RNA polymerase II degradation factor 1

1

5

High-throughput

0.479

High

675520

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

675521

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.479

High

675522

DPOA2
DNA polymerase alpha subunit B

1

2

Small-scale

0.479

High

675524

TRA1
Transcription-associated protein 1

1

9

Small-scale

0.479

High

675525

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

675528

ATAD2
ATPase histone chaperone YTA7

1

5

High-throughput

0.479

High

675532

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

675536

UFD1
Ubiquitin fusion degradation protein 1

1

4

Small-scale

0.479

High

675540

HST2
NAD-dependent protein deacetylase HST2

1

14

High-throughput

0.479

High

675547

SEN1
Helicase SEN1

1

2

Small-scale

0.479

High

675549

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

675550

MLP1
Protein MLP1

1

19

High-throughput

0.479

High

675555

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

675556

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

675557

CAB5
Dephospho-CoA kinase CAB5

1

1

High-throughput

0.479

High

675561

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

4

High-throughput

0.479

High

675562

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

675566

DIA2
Protein DIA2

1

4

Small-scale

0.479

High

675569

MLH3
DNA mismatch repair protein MLH3

1

2

High-throughput

0.479

High

675572

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

675575

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

675577

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.479

High

593800

PRI2
DNA primase large subunit

1

0

Small-scale

0.458

High

632552

RAD51
DNA repair protein RAD51

1

0

Small-scale

0.458

High

675552

ESP1
Separin

1

0

High-throughput

0.458

High

675564

RBX1
RING-box protein HRT1

1

0

Small-scale

0.458

High

675565

SGO1
Shugoshin

1

0

High-throughput

0.458

High

675567

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

360782

TBB
Tubulin beta chain

1

15

High-throughput

0.445

High

367823

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

424387

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.445

High

454223

TBA1
Tubulin alpha-1 chain

1

9

High-throughput

0.445

High

555873

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.445

High

633011

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

675516

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

675526

HSP7E
Heat shock protein SSC3, mitochondrial

1

15

High-throughput

0.445

High

675534

SKP1
Suppressor of kinetochore protein 1

1

1

High-throughput

0.445

High

675543

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.445

High

675558

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.445

High

342883

ENO2
Enolase 2

1

6

High-throughput

0.437

High

343560

PMG1
Phosphoglycerate mutase 1

1

4

High-throughput

0.437

High

472068

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

675515

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

675546

NUM1
Nuclear migration protein NUM1

1

17

High-throughput

0.437

High

675568

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

675535

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

634044

DCC1
Sister chromatid cohesion protein DCC1

1

0

Small-scale

0.249

Low

675551

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

675574

PNS1
Protein PNS1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024