Protein: PRP19
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase PRP19)

Gene: PRP19
Organism: Saccharomyces cerevisiae S288C
Interactions: 164
UniProt ID: P32523

Gene Ontology (top 5):
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

692348

CEF1
Pre-mRNA-splicing factor CEF1

19

9

Small-scale

0.989

High

692269

PRP19
Pre-mRNA-processing factor 19

8

17

Small-scale

0.968

High

692376

CLF1
Pre-mRNA-splicing factor CLF1

14

20

Small-scale

0.762

High

692372

CWC2
Pre-mRNA-splicing factor CWC2

11

4

Small-scale

0.761

High

692352

SYF1
Pre-mRNA-splicing factor SYF1

12

17

Small-scale

0.760

High

598616

ISY1
Pre-mRNA-splicing factor ISY1

12

3

Small-scale

0.758

High

657720

YJU2
Splicing factor YJU2

7

4

Small-scale

0.749

High

692380

PRP46
Pre-mRNA-splicing factor PRP46

7

18

Small-scale

0.744

High

692308

PRP17
Pre-mRNA-processing factor 17

6

18

High-throughput

0.739

High

692358

SN309
Pre-mRNA-splicing factor SNT309

16

0

Small-scale

0.733

High

692370

RU2A
U2 small nuclear ribonucleoprotein A'

6

15

Small-scale

0.729

High

692290

NTC20
Pre-mRNA-splicing factor NTC20

13

0

Small-scale

0.727

High

692327

SYF2
Pre-mRNA-splicing factor SYF2

7

0

Small-scale

0.718

High

655683

PRP45
Pre-mRNA-processing protein 45

5

6

Small-scale

0.714

High

692278

PRP8
Pre-mRNA-splicing factor 8

5

7

Small-scale

0.714

High

692288

SLT11
Pre-mRNA-splicing factor SLT11

5

3

Small-scale

0.714

High

692272

BRR2
Pre-mRNA-splicing helicase BRR2

5

20

Small-scale

0.712

High

692335

RUXF
Small nuclear ribonucleoprotein F

5

6

Small-scale

0.706

High

586469

PRP9
Pre-mRNA-splicing factor PRP9

4

3

Small-scale

0.691

High

692282

SN114
Pre-mRNA-splicing factor SNU114

4

6

Small-scale

0.691

High

692318

SF3B1
U2 snRNP component HSH155

4

20

Small-scale

0.691

High

692328

CWC22
Pre-mRNA-splicing factor CWC22

4

4

High-throughput

0.687

High

692375

USB1
U6 snRNA phosphodiesterase 1

5

0

High-throughput

0.684

High

629362

BUD31
Pre-mRNA-splicing factor BUD31

4

3

Small-scale

0.683

High

692302

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

5

Small-scale

0.683

High

692305

RUXG
Small nuclear ribonucleoprotein G

4

10

Small-scale

0.673

High

692331

CWC25
Pre-mRNA-splicing factor CWC25

3

1

High-throughput

0.667

High

692324

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

14

Small-scale

0.660

High

692270

PRP21
Pre-mRNA-splicing factor PRP21

3

3

Small-scale

0.650

High

692306

IST3
U2 snRNP component IST3

3

12

Small-scale

0.650

High

692309

SMD3
Small nuclear ribonucleoprotein Sm D3

3

17

Small-scale

0.650

High

692341

SMD1
Small nuclear ribonucleoprotein Sm D1

3

3

Small-scale

0.650

High

692343

CUS1
Cold sensitive U2 snRNA suppressor 1

3

3

Small-scale

0.650

High

692354

RSE1
Pre-mRNA-splicing factor RSE1

3

10

Small-scale

0.650

High

692359

SMD2
Small nuclear ribonucleoprotein Sm D2

3

2

Small-scale

0.650

High

692365

PRP11
Pre-mRNA-splicing factor PRP11

3

2

Small-scale

0.650

High

589417

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

17

Small-scale

0.646

High

692369

NCBP2
Nuclear cap-binding protein subunit 2

3

8

High-throughput

0.640

High

692362

URN1
Pre-mRNA-splicing factor URN1

2

0

High-throughput

0.633

High

692342

SPP2
Pre-mRNA-splicing factor SPP2

3

0

Small-scale

0.632

High

622300

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

4

17

Small-scale

0.629

High

692322

CWC23
Pre-mRNA-splicing factor CWC23

2

5

High-throughput

0.628

High

692347

CWC21
Pre-mRNA-splicing factor CWC21

3

0

High-throughput

0.616

High

490659

HSP71
Heat shock protein SSA1

3

17

Small-scale

0.611

High

692312

CWC26
Pre-mRNA-splicing factor CWC26

2

1

High-throughput

0.611

High

692329

CWC24
Pre-mRNA-splicing factor CWC24

2

4

High-throughput

0.611

High

692307

MSL1
U2 small nuclear ribonucleoprotein B''

2

20

Small-scale

0.601

High

692349

CWC15
Pre-mRNA-splicing factor CWC15

2

0

High-throughput

0.585

High

557947

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

692281

NCBP1
Nuclear cap-binding protein complex subunit 1

2

1

High-throughput

0.584

High

692361

SP382
Pre-mRNA-splicing factor SPP382

2

0

Small-scale

0.576

High

589067

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

16

Small-scale

0.571

High

692284

NTR2
Pre-mRNA-splicing factor NTR2

2

1

Small-scale

0.571

High

692344

CWC27
Peptidyl-prolyl isomerase CWC27

2

3

High-throughput

0.571

High

692363

DIB1
Spliceosomal protein DIB1

2

1

Small-scale

0.571

High

692367

PML1
Pre-mRNA leakage protein 1

2

2

Small-scale

0.571

High

692381

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

3

Small-scale

0.571

High

692383

HSH49
Protein HSH49

2

5

Small-scale

0.571

High

675451

PSB7
Proteasome subunit beta type-7

1

5

Small-scale

0.552

High

367862

EF1A
Elongation factor 1-alpha

2

3

Small-scale

0.552

High

510635

SSB1
Ribosome-associated molecular chaperone SSB1

2

16

Small-scale

0.552

High

692271

RU1A
U1 small nuclear ribonucleoprotein A

2

0

Small-scale

0.547

High

675894

XPO1
Exportin-1

1

10

High-throughput

0.536

High

692291

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.513

High

620006

MPIP
M-phase inducer phosphatase

1

4

High-throughput

0.508

High

692275

UFD4
Ubiquitin fusion degradation protein 4

1

16

High-throughput

0.508

High

692385

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

1

High-throughput

0.508

High

477185

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

692368

ESA1
Histone acetyltransferase ESA1

1

5

Small-scale

0.501

High

441688

MSS18
Protein MSS18

1

0

High-throughput

0.493

High

692277

UBC6
Ubiquitin-conjugating enzyme E2 6

1

9

Small-scale

0.481

High

554207

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

18

High-throughput

0.479

High

603288

SNF2
Transcription regulatory protein SNF2

1

11

Small-scale

0.479

High

661654

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

664705

BMH1
Protein BMH1

1

6

High-throughput

0.479

High

691946

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

692292

RCK2
Serine/threonine-protein kinase RCK2

1

7

High-throughput

0.479

High

692340

NOP3
Serine/arginine

1

14

Small-scale

0.479

High

692355

SWR1
Helicase SWR1

1

10

Small-scale

0.479

High

692364

RDS3
Pre-mRNA-splicing factor RDS3

1

1

High-throughput

0.479

High

692374

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

692384

MEX67
mRNA export factor MEX67

1

6

High-throughput

0.479

High

688151

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

692274

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

692279

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.458

High

692283

MUD2
Splicing factor MUD2

1

0

Small-scale

0.458

High

692285

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

692298

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

692310

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

692323

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.458

High

692325

EFM5
Protein-lysine N-methyltransferase EFM5

1

0

High-throughput

0.458

High

692333

FYV6
Protein FYV6

1

0

High-throughput

0.458

High

692373

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

692295

YHS2
MIP18 family protein YHR122W

1

2

High-throughput

0.457

High

334902

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

Small-scale

0.445

High

343569

PMG1
Phosphoglycerate mutase 1

1

1

Small-scale

0.445

High

365990

HSP82
ATP-dependent molecular chaperone HSP82

1

15

High-throughput

0.445

High

406891

RS3
Small ribosomal subunit protein uS3

1

5

Small-scale

0.445

High

407491

RS9B
Small ribosomal subunit protein uS4B

1

4

Small-scale

0.445

High

407803

RS13
Small ribosomal subunit protein uS15

1

4

Small-scale

0.445

High

413383

RS14A
Small ribosomal subunit protein uS11A

1

4

Small-scale

0.445

High

415921

DED1
ATP-dependent RNA helicase DED1

1

9

Small-scale

0.445

High

426273

RS19B
Small ribosomal subunit protein eS19B

1

3

Small-scale

0.445

High

457004

SWI6
Regulatory protein SWI6

1

12

Small-scale

0.445

High

479708

RS4A
Small ribosomal subunit protein eS4A

1

5

Small-scale

0.445

High

481751

RS16B
Small ribosomal subunit protein uS9B

1

8

Small-scale

0.445

High

482150

RS18A
Small ribosomal subunit protein uS13A

1

3

Small-scale

0.445

High

493472

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.445

High

586378

PRP6
Pre-mRNA-splicing factor 6

1

18

Small-scale

0.445

High

604957

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.445

High

627827

SIS1
Protein SIS1

1

3

Small-scale

0.445

High

628846

SWI4
Regulatory protein SWI4

1

12

Small-scale

0.445

High

631745

RS2
Small ribosomal subunit protein uS5

1

4

Small-scale

0.445

High

635821

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

2

Small-scale

0.445

High

644851

RS5
Small ribosomal subunit protein uS7

1

6

Small-scale

0.445

High

645327

RS7A
Small ribosomal subunit protein eS7A

1

4

Small-scale

0.445

High

692273

RSSA1
Small ribosomal subunit protein uS2A

1

3

Small-scale

0.445

High

692276

PRP40
Pre-mRNA-processing protein PRP40

1

2

Small-scale

0.445

High

692280

RS3A1
Small ribosomal subunit protein eS1A

1

2

Small-scale

0.445

High

692286

GBLP
Small ribosomal subunit protein RACK1

1

18

Small-scale

0.445

High

692287

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

17

Small-scale

0.445

High

692293

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

5

Small-scale

0.445

High

692294

RS20
Small ribosomal subunit protein uS10

1

2

Small-scale

0.445

High

692297

DHH1
ATP-dependent RNA helicase DHH1

1

18

Small-scale

0.445

High

692299

MBP1
Transcription factor MBP1

1

15

Small-scale

0.445

High

692300

PRP39
Pre-mRNA-processing factor 39

1

17

Small-scale

0.445

High

692301

SNU13
13 kDa ribonucleoprotein-associated protein

1

8

Small-scale

0.445

High

692303

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

8

Small-scale

0.445

High

692304

SSB2
Ribosome-associated molecular chaperone SSB2

1

16

High-throughput

0.445

High

692311

SAD1
Pre-mRNA-splicing factor SAD1

1

12

Small-scale

0.445

High

692313

LSM1
Sm-like protein LSm1

1

15

Small-scale

0.445

High

692314

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.445

High

692315

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

14

Small-scale

0.445

High

692316

RS12
Small ribosomal subunit protein eS12

1

2

Small-scale

0.445

High

692317

PRP31
Pre-mRNA-processing factor 31

1

6

Small-scale

0.445

High

692319

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

5

Small-scale

0.445

High

692320

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

5

Small-scale

0.445

High

692321

PFD6
Prefoldin subunit 6

1

5

High-throughput

0.445

High

692330

CUS2
Cold sensitive U2 snRNA suppressor 2

1

14

Small-scale

0.445

High

692332

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

15

Small-scale

0.445

High

692334

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.445

High

692336

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

17

Small-scale

0.445

High

692337

NAM8
Protein NAM8

1

4

Small-scale

0.445

High

692339

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

16

Small-scale

0.445

High

692346

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

1

3

Small-scale

0.445

High

692350

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

19

Small-scale

0.445

High

692360

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

6

Small-scale

0.445

High

692366

LUC7
Protein LUC7

1

4

Small-scale

0.445

High

692378

RUXE
Small nuclear ribonucleoprotein E

1

3

Small-scale

0.445

High

692289

SP381
Pre-mRNA-splicing factor SPP381

1

0

Small-scale

0.426

High

692326

SNU71
U1 small nuclear ribonucleoprotein component SNU71

1

0

Small-scale

0.426

High

692338

PRP38
Pre-mRNA-splicing factor 38

1

0

Small-scale

0.426

High

692351

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

1

0

Small-scale

0.426

High

692356

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.426

High

692357

RU1C
U1 small nuclear ribonucleoprotein C

1

0

Small-scale

0.426

High

692377

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

692379

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

Small-scale

0.426

High

549355

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

Small-scale

0.407

High

692296

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.407

High

692345

SLU7
Pre-mRNA-splicing factor SLU7

2

0

High-throughput

0.318

High

692371

YP257
Uncharacterized membrane protein YPL257W

1

0

High-throughput

0.265

Low

692382

YO314
Uncharacterized protein YOR314W

1

0

High-throughput

0.238

Low

692353

KFA
Kynurenine formamidase

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024