Protein: CRKL
Crk-like protein

Gene: CRKL
Organism: Homo sapiens
Interactions: 215
UniProt ID: P46109

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0001568 - blood vessel development
GO:0001655 - urogenital system development
GO:0001764 - neuron migration
GO:0001783 - B cell apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362204

ABL1
Tyrosine-protein kinase ABL1

13

20

Small-scale

0.982

High

362946

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.942

High

699643

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

6

20

Small-scale

0.931

High

855926

DOK1
Docking protein 1

5

20

Small-scale

0.928

High

855840

BCAR1
Breast cancer anti-estrogen resistance protein 1

5

20

Small-scale

0.915

High

855872

CASL
Enhancer of filamentation 1

4

20

Small-scale

0.893

High

855866

GAB1
GRB2-associated-binding protein 1

4

20

Small-scale

0.886

High

855855

SOS1
Son of sevenless homolog 1

4

20

High-throughput

0.881

High

855883

TENS2
Tensin-2

4

8

High-throughput

0.870

High

838343

STA5A
Signal transducer and activator of transcription 5A

3

4

Small-scale

0.870

High

539970

BCR
Breakpoint cluster region protein

3

20

Small-scale

0.864

High

619213

EPOR
Erythropoietin receptor

3

20

Small-scale

0.857

High

855955

GAB2
GRB2-associated-binding protein 2

3

20

Small-scale

0.854

High

193229

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.834

High

855954

ALK
ALK tyrosine kinase receptor

3

20

Small-scale

0.827

High

855858

ARHG5
Rho guanine nucleotide exchange factor 5

3

20

High-throughput

0.821

High

855832

CRKL
Crk-like protein

2

20

Small-scale

0.812

High

855871

DOCK1
Dedicator of cytokinesis protein 1

2

20

High-throughput

0.811

High

855897

PRAG1
Inactive tyrosine-protein kinase PRAG1

2

12

High-throughput

0.811

High

855940

DOCK5
Dedicator of cytokinesis protein 5

2

18

High-throughput

0.811

High

136330

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.806

High

855852

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.806

High

463015

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.783

High

855837

BLK
Tyrosine-protein kinase Blk

2

20

High-throughput

0.783

High

410704

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

651214

CBL
E3 ubiquitin-protein ligase CBL

38

20

Small-scale

0.770

High

532062

KIT
Mast/stem cell growth factor receptor Kit

2

20

Small-scale

0.768

High

855869

RPGF1
Rap guanine nucleotide exchange factor 1

16

20

Small-scale

0.762

High

708836

PTN4
Tyrosine-protein phosphatase non-receptor type 4

2

20

High-throughput

0.754

High

855880

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

10

High-throughput

0.737

High

855918

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

High-throughput

0.737

High

67633

RHG32
Rho GTPase-activating protein 32

1

20

Small-scale

0.724

High

849121

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.724

High

855915

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.724

High

593307

PGFRA
Platelet-derived growth factor receptor alpha

1

20

Small-scale

0.715

High

320385

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.713

High

855916

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

4

20

Small-scale

0.702

High

65904

RHG42
Rho GTPase-activating protein 42

1

20

High-throughput

0.691

High

839137

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

17

High-throughput

0.691

High

840933

ABL2
Tyrosine-protein kinase ABL2

1

20

High-throughput

0.691

High

855856

SOS2
Son of sevenless homolog 2

1

20

High-throughput

0.691

High

855908

ASAP3
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

1

20

High-throughput

0.691

High

855953

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.691

High

609961

VGFR1
Vascular endothelial growth factor receptor 1

1

20

Small-scale

0.665

High

855959

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

3

20

Small-scale

0.664

High

855865

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

3

6

High-throughput

0.662

High

855863

CBLB
E3 ubiquitin-protein ligase CBL-B

3

20

Small-scale

0.660

High

855851

NOTC2
Neurogenic locus notch homolog protein 2

1

5

High-throughput

0.656

High

855941

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.656

High

855931

UBL5
Ubiquitin-like protein 5

1

0

High-throughput

0.656

High

855906

RIN3
Ras and Rab interactor 3

3

20

High-throughput

0.654

High

786983

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.647

High

855902

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

855952

KDIS
Kinase D-interacting substrate of 220 kDa

1

4

Small-scale

0.647

High

855835

PAXI
Paxillin

2

20

Small-scale

0.629

High

855888

EDC4
Enhancer of mRNA-decapping protein 4

2

7

High-throughput

0.628

High

855920

EDC3
Enhancer of mRNA-decapping protein 3

2

1

High-throughput

0.628

High

855939

PEAK1
Inactive tyrosine-protein kinase PEAK1

2

20

High-throughput

0.628

High

855929

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

16

High-throughput

0.621

High

157066

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.618

High

241013

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.618

High

411542

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

541387

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.618

High

648455

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

710114

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

710679

EPHA8
Ephrin type-A receptor 8

1

20

High-throughput

0.618

High

711275

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

714588

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

855838

STA5B
Signal transducer and activator of transcription 5B

1

4

Small-scale

0.618

High

855839

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

855847

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

855857

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.618

High

855876

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

Small-scale

0.618

High

855893

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

855909

BLNK
B-cell linker protein

1

20

Small-scale

0.618

High

855910

ASB11
Ankyrin repeat and SOCS box protein 11

1

9

High-throughput

0.618

High

855914

DOCK2
Dedicator of cytokinesis protein 2

1

17

Small-scale

0.618

High

855927

RHG09
Rho GTPase-activating protein 9

1

20

High-throughput

0.618

High

855936

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

855950

UBQL2
Ubiquilin-2

1

8

High-throughput

0.618

High

839710

EPS15
Epidermal growth factor receptor substrate 15

2

14

High-throughput

0.611

High

855923

ELMO2
Engulfment and cell motility protein 2

2

10

High-throughput

0.611

High

855958

MARF1
Meiosis regulator and mRNA stability factor 1

2

1

High-throughput

0.611

High

58709

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

2

10

High-throughput

0.606

High

855844

PRS10
26S proteasome regulatory subunit 10B

2

4

High-throughput

0.606

High

175463

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

2

6

High-throughput

0.594

High

249728

DOK2
Docking protein 2

2

20

High-throughput

0.594

High

705270

GRN
Progranulin

2

2

High-throughput

0.594

High

439677

INSR
Insulin receptor

1

20

Small-scale

0.590

High

371415

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

641521

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.579

High

109541

G5E9C8
SOS Ras/Rac guanine nucleotide exchange factor 1

1

20

High-throughput

0.575

High

178080

FYB1
FYN-binding protein 1

1

16

Small-scale

0.575

High

855886

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.575

High

855947

SPN90
NCK-interacting protein with SH3 domain

1

7

High-throughput

0.575

High

286348

DAB1
Disabled homolog 1

1

20

Small-scale

0.561

High

842621

WASP
Actin nucleation-promoting factor WAS

1

20

Small-scale

0.561

High

855895

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

2

2

High-throughput

0.553

High

463921

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.553

High

855921

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

675403

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.541

High

855846

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.541

High

705900

CD34
Hematopoietic progenitor cell antigen CD34

1

0

Small-scale

0.537

High

659179

SP100
Nuclear autoantigen Sp-100

1

4

High-throughput

0.536

High

684116

DDX6
Probable ATP-dependent RNA helicase DDX6

1

9

High-throughput

0.536

High

855834

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.536

High

855898

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.536

High

855913

ELMO1
Engulfment and cell motility protein 1

1

10

High-throughput

0.536

High

855917

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

8

High-throughput

0.536

High

855943

DCP1A
mRNA-decapping enzyme 1A

1

7

High-throughput

0.536

High

855864

BIK
Bcl-2-interacting killer

1

0

High-throughput

0.518

High

403144

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

855848

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

855860

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.513

High

855882

GORAB
RAB6-interacting golgin

1

0

High-throughput

0.513

High

855890

GDPP1
GDP-D-glucose phosphorylase 1

1

0

High-throughput

0.513

High

855948

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

855960

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.513

High

180490

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.508

High

183230

LAMA5
Laminin subunit alpha-5

1

6

High-throughput

0.508

High

160440

IRS4
Insulin receptor substrate 4

1

15

Small-scale

0.501

High

333449

MPZL1
Myelin protein zero-like protein 1

1

5

High-throughput

0.489

High

855859

PNRC1
Proline-rich nuclear receptor coactivator 1

1

1

High-throughput

0.489

High

855885

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.486

High

855854

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

18

High-throughput

0.481

High

855900

PHC2
Polyhomeotic-like protein 2

1

12

High-throughput

0.481

High

855903

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

6

High-throughput

0.481

High

855905

LIPB2
Liprin-beta-2

1

9

High-throughput

0.481

High

855928

WAC
WW domain-containing adapter protein with coiled-coil

1

8

High-throughput

0.481

High

855938

GARE1
GRB2-associated and regulator of MAPK protein 1

1

9

High-throughput

0.481

High

176037

KDM6B
Lysine-specific demethylase 6B

1

9

Small-scale

0.479

High

855874

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

855875

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

246467

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.479

High

315248

RECQ4
ATP-dependent DNA helicase Q4

1

7

High-throughput

0.479

High

330741

KI20A
Kinesin-like protein KIF20A

1

11

High-throughput

0.479

High

341535

EYA4
Protein phosphatase EYA4

1

3

High-throughput

0.479

High

345492

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

347567

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

348077

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.479

High

352354

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.479

High

385538

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

431744

ITB1
Integrin beta-1

1

7

Small-scale

0.479

High

536700

HSP7C
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.479

High

555940

CADH1
Cadherin-1

1

18

High-throughput

0.479

High

557933

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

560323

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

588136

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

694858

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

767634

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

832958

ETV6
Transcription factor ETV6

1

5

Small-scale

0.479

High

853618

MK08
Mitogen-activated protein kinase 8

1

4

Small-scale

0.479

High

855833

YAP1
Transcriptional coactivator YAP1

1

13

High-throughput

0.479

High

855836

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

855841

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

855842

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

855843

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

855845

RB11A
Ras-related protein Rab-11A

1

9

High-throughput

0.479

High

855849

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.479

High

855850

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

855861

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.479

High

855862

RFA4
Replication protein A 30 kDa subunit

1

7

High-throughput

0.479

High

855867

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

855868

HDAC1
Histone deacetylase 1

1

2

High-throughput

0.479

High

855870

TRI14
Tripartite motif-containing protein 14

1

14

High-throughput

0.479

High

855873

CUL7
Cullin-7

1

1

High-throughput

0.479

High

855878

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.479

High

855881

CE170
Centrosomal protein of 170 kDa

1

16

High-throughput

0.479

High

855896

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

855899

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

20

High-throughput

0.479

High

855901

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.479

High

855911

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

855912

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

High-throughput

0.479

High

855919

PF21A
PHD finger protein 21A

1

8

High-throughput

0.479

High

855922

BICD1
Protein bicaudal D homolog 1

1

7

High-throughput

0.479

High

855932

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

855935

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

855937

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

855942

GPVI
Platelet glycoprotein VI

1

4

Small-scale

0.479

High

855944

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

Small-scale

0.479

High

855946

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

855949

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

855951

RCOR1
REST corepressor 1

1

5

High-throughput

0.479

High

855956

NINL
Ninein-like protein

1

11

High-throughput

0.479

High

642697

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

6

High-throughput

0.470

High

270521

MEGF6
Multiple epidermal growth factor-like domains protein 6

1

10

High-throughput

0.464

High

855853

AOXA
Aldehyde oxidase

1

0

High-throughput

0.460

High

96631

E9PAV9
G patch domain-containing protein 4

1

0

High-throughput

0.458

High

176451

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

855877

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

855889

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

855925

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

4

Small-scale

0.457

High

404718

PRIO
Major prion protein

1

4

High-throughput

0.445

High

429484

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

529295

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.445

High

619588

VCAM1
Vascular cell adhesion protein 1

1

16

High-throughput

0.445

High

855879

Q5JVZ5
Engulfment and cell motility 2

1

10

High-throughput

0.445

High

855884

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.445

High

855933

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

105525

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

553345

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

20

Small-scale

0.437

High

628349

CD33
Myeloid cell surface antigen CD33

1

8

Small-scale

0.437

High

855891

PEAK3
Protein PEAK3

1

15

Small-scale

0.437

High

855930

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.437

High

855945

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

855957

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

516824

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.417

High

855887

Q6NSK7
RIN3 protein

1

20

High-throughput

0.417

High

855894

NEK10
Serine/threonine-protein kinase Nek10

1

10

High-throughput

0.407

High

855924

MF14A
Hippocampus abundant transcript 1 protein

1

1

High-throughput

0.407

High

855934

TM168
Transmembrane protein 168

2

0

High-throughput

0.310

High

855904

CO054
Putative uncharacterized protein encoded by LINC02915

1

0

High-throughput

0.279

Low

855907

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.249

Low

855892

MFSD6
Major facilitator superfamily domain-containing protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025