Protein: GYRA
DNA gyrase subunit A (EC 5.6.2.2)

Gene: GYRA
Organism: Escherichia coli K-12
Interactions: 60
UniProt ID: P0AES4

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 - ATP binding
GO:0005694 - chromosome
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

468464

GYRA
DNA gyrase subunit A

4

6

Small-scale

0.894

High

468465

GYRB
DNA gyrase subunit B

2

12

Small-scale

0.759

High

468488

CCDB
Toxin CcdB

1

0

Small-scale

0.687

High

468467

PARC
DNA topoisomerase 4 subunit A

1

6

High-throughput

0.625

High

461794

RS2
Small ribosomal subunit protein uS2

2

1

High-throughput

0.612

High

462839

SSRP
SsrA-binding protein

2

1

High-throughput

0.601

High

442690

DNAJ
Chaperone protein DnaJ

2

1

High-throughput

0.588

High

465376

MREB
Cell shape-determining protein MreB

2

6

High-throughput

0.588

High

466418

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

2

2

High-throughput

0.588

High

468472

EFTU1
Elongation factor Tu 1

2

1

High-throughput

0.588

High

468471

SSB
Single-stranded DNA-binding protein

2

1

High-throughput

0.571

High

459592

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

2

0

High-throughput

0.563

High

460339

RECA
Protein RecA

2

0

High-throughput

0.563

High

462784

METK
S-adenosylmethionine synthase

2

0

High-throughput

0.563

High

468466

MOG
Molybdopterin adenylyltransferase

2

0

High-throughput

0.563

High

468469

RHO
Transcription termination factor Rho

2

0

High-throughput

0.563

High

468477

ADD
Adenosine deaminase

2

0

High-throughput

0.563

High

468493

HSCC
Chaperone protein HscC

1

3

High-throughput

0.536

High

463464

YACG
DNA gyrase inhibitor YacG

1

0

High-throughput

0.523

High

337276

AAT
Aspartate aminotransferase

1

0

High-throughput

0.513

High

468474

SYR
Arginine--tRNA ligase

1

0

High-throughput

0.513

High

468475

FDHE
Protein FdhE

1

0

High-throughput

0.513

High

468478

ACRD
Probable aminoglycoside efflux pump

1

0

High-throughput

0.513

High

468483

CAS3
CRISPR-associated endonuclease/helicase Cas3

1

0

High-throughput

0.513

High

468494

LSRK
Autoinducer-2 kinase

1

0

High-throughput

0.513

High

420933

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

1

3

High-throughput

0.484

High

459138

DNAK
Chaperone protein DnaK

1

3

High-throughput

0.484

High

462325

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.484

High

465055

DLDH
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.484

High

465833

PSTB
Phosphate import ATP-binding protein PstB

1

1

High-throughput

0.484

High

468470

SRP54
Signal recognition particle protein

1

1

High-throughput

0.484

High

468489

MALK
Maltose/maltodextrin import ATP-binding protein MalK

1

1

High-throughput

0.484

High

459543

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

1

High-throughput

0.479

High

343908

SYGB
Glycine--tRNA ligase beta subunit

1

0

High-throughput

0.464

High

458302

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

464473

FTSZ
Cell division protein FtsZ

1

0

High-throughput

0.464

High

468476

ZRAS
Sensor protein ZraS

1

0

High-throughput

0.464

High

468485

YJFZ
Uncharacterized protein YjfZ

1

0

High-throughput

0.464

High

468468

GCH1L
GTP cyclohydrolase 1 type 2 homolog

1

0

High-throughput

0.458

High

468481

SBMC
DNA gyrase inhibitor

1

0

Small-scale

0.458

High

468487

CCDA
Antitoxin CcdA

1

0

Small-scale

0.458

High

468490

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.458

High

468492

YFFS
Uncharacterized protein YffS

1

0

High-throughput

0.458

High

460915

RL27
Large ribosomal subunit protein bL27

1

1

High-throughput

0.457

High

468473

EFTU2
Elongation factor Tu 2

1

1

High-throughput

0.445

High

458823

RSMG
Ribosomal RNA small subunit methyltransferase G

1

0

High-throughput

0.438

High

461172

RL36
Large ribosomal subunit protein bL36A

1

0

High-throughput

0.438

High

461621

RS19
Small ribosomal subunit protein uS19

1

0

High-throughput

0.438

High

468113

CHEY
Chemotaxis protein CheY

1

0

High-throughput

0.438

High

468480

FLIS
Flagellar secretion chaperone FliS

1

0

High-throughput

0.438

High

468482

DHAM
PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM

1

0

High-throughput

0.426

High

459943

NRDI
Protein NrdI

1

0

High-throughput

0.279

Low

465178

IDNO
5-keto-D-gluconate 5-reductase

1

0

High-throughput

0.279

Low

468479

LPXM
Lipid A biosynthesis myristoyltransferase

1

0

High-throughput

0.279

Low

468484

YJEJ
Uncharacterized protein YjeJ

1

0

High-throughput

0.279

Low

468486

RTCB
RNA-splicing ligase RtcB

1

0

High-throughput

0.279

Low

466771

FLIG
Flagellar motor switch protein FliG

1

0

High-throughput

0.238

Low

468393

FLGM
Negative regulator of flagellin synthesis

1

0

High-throughput

0.238

Low

468491

A2MGH
Putative alpha-2-macroglobulin homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024