Protein: SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5 (EC 2.3.2.27) (Hexose metabolism-related protein HEX3) (RING-type E3 ubiquitin transferase SLX5) (Synthetic lethal of unknown function protein 5)

Gene: SLX5
Organism: Saccharomyces cerevisiae S288C
Interactions: 80
UniProt ID: P32828

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

698549

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

13

0

Small-scale

0.726

High

698582

SMT3
Ubiquitin-like protein SMT3

9

0

Small-scale

0.714

High

549799

UBC4
Ubiquitin-conjugating enzyme E2 4

4

1

Small-scale

0.686

High

698536

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

4

0

Small-scale

0.649

High

698571

EUC1
Transcription factor-like protein EUC1

3

0

Small-scale

0.644

High

698538

CENPA
Histone H3-like centromeric protein CSE4

3

0

Small-scale

0.613

High

691887

CBF3A
Centromere DNA-binding protein complex CBF3 subunit A

3

0

Small-scale

0.612

High

483019

HMAL2
Silenced mating-type protein ALPHA2

2

0

Small-scale

0.603

High

549853

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

2

1

Small-scale

0.602

High

698567

NSE5
Non-structural maintenance of chromosome element 5

2

0

Small-scale

0.587

High

698570

SIZ1
E3 SUMO-protein ligase SIZ1

1

1

Small-scale

0.586

High

698579

ELG1
Telomere length regulation protein ELG1

2

0

Small-scale

0.583

High

523360

SRS2
ATP-dependent DNA helicase SRS2

2

0

Small-scale

0.569

High

698548

YEN1
Holliday junction resolvase YEN1

1

0

Small-scale

0.558

High

698577

ULS1
ATP-dependent helicase ULS1

1

0

Small-scale

0.529

High

419608

RAD52
DNA repair and recombination protein RAD52

1

0

Small-scale

0.513

High

667358

PTP2
Tyrosine-protein phosphatase 2

1

0

High-throughput

0.513

High

698552

LSM1
Sm-like protein LSm1

1

1

High-throughput

0.508

High

698562

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

1

High-throughput

0.508

High

416212

SIR2
NAD-dependent histone deacetylase SIR2

1

0

Small-scale

0.504

High

692453

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.504

High

614590

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

614912

KC12
Casein kinase I homolog 2

1

1

High-throughput

0.501

High

698580

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

Small-scale

0.501

High

698578

THP3
Protein THP3

1

0

High-throughput

0.493

High

586475

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.486

High

698543

LIN1
Protein LIN1

1

0

Small-scale

0.486

High

698564

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.486

High

698557

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.481

High

477192

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.480

High

659860

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.480

High

698537

HSL1
Probable serine/threonine-protein kinase HSL1

1

0

High-throughput

0.480

High

698541

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.480

High

698566

SKY1
Serine/threonine-protein kinase SKY1

1

0

High-throughput

0.480

High

698573

ESC2
Protein ESC2

1

0

Small-scale

0.480

High

698585

NCB2
Negative cofactor 2 complex subunit beta

1

0

Small-scale

0.480

High

366021

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.479

High

454256

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.479

High

604965

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

698563

ACT
Actin

1

0

High-throughput

0.479

High

631655

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

Small-scale

0.460

High

660039

KIP1
Kinesin-like protein KIP1

1

0

High-throughput

0.460

High

687526

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.460

High

687675

BTAF1
TATA-binding protein-associated factor MOT1

1

0

Small-scale

0.460

High

698539

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

698542

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.460

High

698544

IPL1
Spindle assembly checkpoint kinase

1

0

High-throughput

0.460

High

698547

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

698550

NDC80
Kinetochore protein NDC80

1

0

Small-scale

0.460

High

698554

BIR1
Protein BIR1

1

0

High-throughput

0.460

High

698565

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.460

High

661726

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

341974

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.457

High

423807

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

698568

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

698583

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.445

High

698545

MET30
F-box protein MET30

1

0

High-throughput

0.438

High

698574

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.438

High

356356

H4
Histone H4

1

0

High-throughput

0.426

High

510705

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

698558

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

698555

JSN1
Protein JSN1

1

0

High-throughput

0.282

High

698560

SSK2
MAP kinase kinase kinase SSK2

1

0

High-throughput

0.279

Low

698576

SSK1
Osmolarity two-component system protein SSK1

1

0

High-throughput

0.279

Low

698540

YRO2
Protein YRO2

1

0

High-throughput

0.269

Low

698581

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.269

Low

698551

PRK1
Actin-regulating kinase PRK1

1

0

High-throughput

0.261

Low

698559

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

421603

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

424420

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.261

Low

604373

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

698569

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.249

Low

698572

ECM7
Protein ECM7

1

0

High-throughput

0.238

Low

698584

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.238

Low

698546

IMDH1
Putative inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.232

Low

698553

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low

698556

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.232

Low

698561

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

698575

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024