Protein: MED5
Mediator of RNA polymerase II transcription subunit 5 (Mediator complex subunit 5) (Negative regulator of URS2 protein 1)

Gene: MED5, NUT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P53114

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006366 - transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686857

MED16
Mediator of RNA polymerase II transcription subunit 16

6

0

Small-scale

0.896

High

693935

MED18
Mediator of RNA polymerase II transcription subunit 18

10

0

Small-scale

0.722

High

859242

MED7
Mediator of RNA polymerase II transcription subunit 7

7

0

Small-scale

0.713

High

693555

MED17
Mediator of RNA polymerase II transcription subunit 17

7

0

Small-scale

0.710

High

748110

MED8
Mediator of RNA polymerase II transcription subunit 8

6

0

Small-scale

0.697

High

859247

MED1
Mediator of RNA polymerase II transcription subunit 1

5

0

Small-scale

0.686

High

693601

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.679

High

859244

MED2
Mediator of RNA polymerase II transcription subunit 2

5

0

Small-scale

0.676

High

586325

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.661

High

704159

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.661

High

814164

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.661

High

859249

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

Small-scale

0.661

High

581374

MED14
Mediator of RNA polymerase II transcription subunit 14

4

0

Small-scale

0.657

High

710271

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

Small-scale

0.657

High

754283

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.657

High

626040

MED19
Mediator of RNA polymerase II transcription subunit 19

4

0

Small-scale

0.649

High

772513

MED3
Mediator of RNA polymerase II transcription subunit 3

4

0

Small-scale

0.649

High

635998

SRB8
Mediator of RNA polymerase II transcription subunit 12

3

0

Small-scale

0.628

High

758005

SSN2
Mediator of RNA polymerase II transcription subunit 13

3

0

Small-scale

0.628

High

859251

MED11
Mediator of RNA polymerase II transcription subunit 11

3

0

Small-scale

0.628

High

859241

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

Small-scale

0.622

High

814143

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

3

0

High-throughput

0.616

High

662815

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.559

High

512058

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

751470

MED31
Mediator of RNA polymerase II transcription subunit 31

2

0

High-throughput

0.547

High

859246

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

412577

CDC7
Cell division control protein 7

1

0

High-throughput

0.513

High

587871

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

859243

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.513

High

375449

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

407193

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

425550

RAD2
DNA repair protein RAD2

1

0

Small-scale

0.458

High

482360

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

544110

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

558164

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

715710

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

728284

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

751056

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

754370

RPP1
Ribonuclease P/MRP protein subunit RPP1

1

0

High-throughput

0.458

High

760580

SSN3
Meiotic mRNA stability protein kinase SSN3

1

0

High-throughput

0.458

High

858492

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.458

High

859239

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

859240

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

859245

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

859250

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

491881

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

494492

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

695129

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

768974

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

743606

HMT1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.438

High

355555

H2B1
Histone H2B.1

1

0

High-throughput

0.426

High

560738

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

705442

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

733274

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

854642

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

859238

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.426

High

413614

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

480211

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480780

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

700524

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

700995

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

706381

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

820068

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

859237

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

629006

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.232

Low

859248

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024