Protein: HOA
4-hydroxy-2-oxovalerate aldolase (HOA) (EC 4.1.3.39) (4-hydroxy-2-keto-pentanoic acid aldolase) (4-hydroxy-2-oxopentanoate aldolase)

Gene: HOA, mhpE
Organism: Escherichia coli K-12
Interactions: 11
UniProt ID: P51020

Gene Ontology (top 5):
GO:0003852 - 2-isopropylmalate synthase activity
GO:0008701 - 4-hydroxy-2-oxovalerate aldolase activity
GO:0009098 - L-leucine biosynthetic process
GO:0019380 - 3-phenylpropionate catabolic process
GO:0030145 - manganese ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

899774

ACDH
Acetaldehyde dehydrogenase

2

0

Small-scale

0.716

High

367453

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.282

High

489893

CH60
Chaperonin GroEL

1

0

High-throughput

0.279

Low

491676

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.279

Low

497669

RSUA
Ribosomal small subunit pseudouridine synthase A

1

0

High-throughput

0.279

Low

497866

FDNH
Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit

1

0

High-throughput

0.279

Low

499877

RL14
Large ribosomal subunit protein uL14

1

0

High-throughput

0.279

Low

501431

SUBI
Sulfate-binding protein

1

0

High-throughput

0.279

Low

559638

GLPD
Aerobic glycerol-3-phosphate dehydrogenase

1

0

High-throughput

0.279

Low

811703

USPG
Universal stress protein UP12

1

0

High-throughput

0.279

Low

895685

MLC
DNA-binding transcriptional repressor Mlc

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025