Protein: KPRS
Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate synthase) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase)

Gene: KPRS, prs
Organism: Escherichia coli K-12
Interactions: 165
UniProt ID: P0A717

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

489479

CH60
Chaperonin GroEL

2

1

High-throughput

0.624

High

473244

DNAJ
Chaperone protein DnaJ

2

5

High-throughput

0.594

High

491638

EFTU1
Elongation factor Tu 1

2

3

High-throughput

0.594

High

491665

CBPA
Curved DNA-binding protein

2

3

High-throughput

0.594

High

491669

RLUB
Ribosomal large subunit pseudouridine synthase B

2

1

High-throughput

0.594

High

491703

YDGJ
Uncharacterized oxidoreductase YdgJ

2

1

High-throughput

0.594

High

491640

LPXB
Lipid-A-disaccharide synthase

2

0

High-throughput

0.585

High

491710

YDJI
Uncharacterized protein YdjI

2

0

High-throughput

0.569

High

491584

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.547

High

491585

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.547

High

491622

RL16
Large ribosomal subunit protein uL16

2

0

High-throughput

0.547

High

491629

NUSA
Transcription termination/antitermination protein NusA

2

0

High-throughput

0.547

High

491683

RL2
Large ribosomal subunit protein uL2

2

0

High-throughput

0.547

High

421034

FUMC
Fumarate hydratase class II

1

1

High-throughput

0.536

High

490231

CLPP
ATP-dependent Clp protease proteolytic subunit

1

2

High-throughput

0.536

High

491588

METK
S-adenosylmethionine synthase

1

1

High-throughput

0.536

High

491595

XERC
Tyrosine recombinase XerC

1

1

High-throughput

0.536

High

491596

XERD
Tyrosine recombinase XerD

1

1

High-throughput

0.536

High

491598

FNR
Fumarate and nitrate reduction regulatory protein

1

1

High-throughput

0.536

High

491607

OMPR
DNA-binding dual transcriptional regulator OmpR

1

3

High-throughput

0.536

High

491611

ACCA
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

1

1

High-throughput

0.536

High

491614

HNS
DNA-binding protein H-NS

1

1

High-throughput

0.536

High

491615

STPA
DNA-binding protein StpA

1

1

High-throughput

0.536

High

491624

DPIA
Transcriptional regulatory protein DpiA

1

3

High-throughput

0.536

High

491660

BASR
Transcriptional regulatory protein BasR

1

3

High-throughput

0.536

High

491661

MODF
ABC transporter ATP-binding protein ModF

1

2

High-throughput

0.536

High

491664

RLUD
Ribosomal large subunit pseudouridine synthase D

1

1

High-throughput

0.536

High

491677

RSTA
Transcriptional regulatory protein RstA

1

3

High-throughput

0.536

High

491700

DDPD
Probable D,D-dipeptide transport ATP-binding protein DdpD

1

1

High-throughput

0.536

High

491708

DDPF
Probable D,D-dipeptide transport ATP-binding protein DdpF

1

1

High-throughput

0.536

High

491693

NPD
NAD-dependent protein deacylase

1

2

High-throughput

0.527

High

491601

ARCA
Aerobic respiration control protein ArcA

1

3

High-throughput

0.515

High

491644

SBCC
Nuclease SbcCD subunit C

1

3

High-throughput

0.515

High

491682

RSMH
Ribosomal RNA small subunit methyltransferase H

1

1

High-throughput

0.515

High

368510

MANA
Mannose-6-phosphate isomerase

1

0

High-throughput

0.513

High

421028

PABB
Aminodeoxychorismate synthase component 1

1

0

High-throughput

0.513

High

457823

THGA
Galactoside O-acetyltransferase

1

0

High-throughput

0.513

High

469919

RECB
RecBCD enzyme subunit RecB

1

0

High-throughput

0.513

High

490796

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.513

High

491570

PROB
Glutamate 5-kinase

1

0

High-throughput

0.513

High

491571

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.513

High

491589

SUCC
Succinate--CoA ligase [ADP-forming] subunit beta

1

0

High-throughput

0.513

High

491590

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.513

High

491591

TUSA
Sulfur carrier protein TusA

1

0

High-throughput

0.513

High

491592

YEBC
Probable transcriptional regulatory protein YebC

1

0

High-throughput

0.513

High

491593

PSRP
Phosphoenolpyruvate synthase regulatory protein

1

0

High-throughput

0.513

High

491594

YQGF
Putative pre-16S rRNA nuclease

1

0

High-throughput

0.513

High

491597

CSPE
Cold shock-like protein CspE

1

0

High-throughput

0.513

High

491599

MNTR
Transcriptional regulator MntR

1

0

High-throughput

0.513

High

491602

FTSE
Cell division ATP-binding protein FtsE

1

0

High-throughput

0.513

High

491603

LIVG
High-affinity branched-chain amino acid transport ATP-binding protein LivG

1

0

High-throughput

0.513

High

491610

YCII
Protein YciI

1

0

High-throughput

0.513

High

491618

KPYK1
Pyruvate kinase I

1

0

High-throughput

0.513

High

491625

MIAB
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase

1

0

High-throughput

0.513

High

491635

THIO2
Thioredoxin 2

1

0

High-throughput

0.513

High

491641

UNG
Uracil-DNA glycosylase

1

0

High-throughput

0.513

High

491642

BIOA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

1

0

High-throughput

0.513

High

491648

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

High-throughput

0.513

High

491653

DBPA
ATP-dependent RNA helicase DbpA

1

0

High-throughput

0.513

High

491654

MRAZ
Transcriptional regulator MraZ

1

0

High-throughput

0.513

High

491655

MUKB
Chromosome partition protein MukB

1

0

High-throughput

0.513

High

491656

MUKE
Chromosome partition protein MukE

1

0

High-throughput

0.513

High

491668

RMLD
dTDP-4-dehydrorhamnose reductase

1

0

High-throughput

0.513

High

491671

SPRT
Protein SprT

1

0

High-throughput

0.513

High

491672

YHAK
Pirin-like protein YhaK

1

0

High-throughput

0.513

High

491673

XAPA
Purine nucleoside phosphorylase 2

1

0

High-throughput

0.513

High

491678

ABPB
Anti-bacteriophage protein B

1

0

High-throughput

0.513

High

491680

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.513

High

491681

PRP2
Serine/threonine-protein phosphatase 2

1

0

High-throughput

0.513

High

491689

PROXY
Multifunctional Ser/Thr-tRNA deacylase ProXp-y

1

0

High-throughput

0.513

High

491699

YAHF
Uncharacterized protein YahF

1

0

High-throughput

0.513

High

491583

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.500

High

491639

EFTU2
Elongation factor Tu 2

1

3

High-throughput

0.500

High

491684

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.500

High

491572

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.493

High

491628

NSRR
HTH-type transcriptional repressor NsrR

1

0

High-throughput

0.493

High

491666

RDGC
Recombination-associated protein RdgC

1

0

High-throughput

0.493

High

491616

MELR
Melibiose operon regulatory protein

1

2

High-throughput

0.489

High

491617

ALLS
HTH-type transcriptional activator AllS

1

6

High-throughput

0.489

High

491663

YFIE
Uncharacterized HTH-type transcriptional regulator YfiE

1

6

High-throughput

0.489

High

491690

AAER
HTH-type transcriptional activator AaeR

1

6

High-throughput

0.489

High

491701

YNEJ
Uncharacterized HTH-type transcriptional regulator YneJ

1

6

High-throughput

0.489

High

491702

PGRR
HTH-type transcriptional regulator PgrR

1

6

High-throughput

0.489

High

491704

WCAA
Putative colanic acid biosynthesis glycosyl transferase WcaA

1

1

High-throughput

0.489

High

491709

YAHB
Uncharacterized HTH-type transcriptional regulator YahB

1

6

High-throughput

0.489

High

491712

YAHD
Putative ankyrin repeat protein YahD

1

3

High-throughput

0.489

High

382633

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.479

High

383988

RL15
Large ribosomal subunit protein uL15

1

0

High-throughput

0.479

High

491586

RS5
Small ribosomal subunit protein uS5

1

0

High-throughput

0.479

High

490118

CH10
Co-chaperonin GroES

1

1

High-throughput

0.479

High

491600

RBSK
Ribokinase

1

1

High-throughput

0.479

High

491612

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

6

High-throughput

0.479

High

491647

DNLJ
DNA ligase

1

1

High-throughput

0.479

High

491652

SRMB
ATP-dependent RNA helicase SrmB

1

1

High-throughput

0.479

High

491667

PGM
Phosphoglucomutase

1

1

High-throughput

0.479

High

491715

NAC
Nitrogen assimilation regulatory protein nac

1

6

High-throughput

0.470

High

460389

SYL
Leucine--tRNA ligase

1

0

High-throughput

0.458

High

491569

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.458

High

491609

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.458

High

491691

HDA
DnaA regulatory inactivator Hda

1

0

High-throughput

0.458

High

490990

DNAK
Chaperone protein DnaK

1

3

High-throughput

0.445

High

491605

MREB
Cell shape-determining protein MreB

1

13

High-throughput

0.445

High

491626

GYRB
DNA gyrase subunit B

1

1

High-throughput

0.445

High

491632

RHO
Transcription termination factor Rho

1

2

High-throughput

0.445

High

491568

MURA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

1

0

High-throughput

0.426

High

491574

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.426

High

491575

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.426

High

491576

RL7
Large ribosomal subunit protein bL12

1

0

High-throughput

0.426

High

491577

RL19
Large ribosomal subunit protein bL19

1

0

High-throughput

0.426

High

491578

RL28
Large ribosomal subunit protein bL28

1

0

High-throughput

0.426

High

491579

RL9
Large ribosomal subunit protein bL9

1

0

High-throughput

0.426

High

491580

RS10
Small ribosomal subunit protein uS10

1

0

High-throughput

0.426

High

491581

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.426

High

491582

RS20
Small ribosomal subunit protein bS20

1

0

High-throughput

0.426

High

491587

RS8
Small ribosomal subunit protein uS8

1

0

High-throughput

0.426

High

491606

RL13
Large ribosomal subunit protein uL13

1

0

High-throughput

0.426

High

491621

RL14
Large ribosomal subunit protein uL14

1

0

High-throughput

0.426

High

491623

RL23
Large ribosomal subunit protein uL23

1

0

High-throughput

0.426

High

491630

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.426

High

491633

RL21
Large ribosomal subunit protein bL21

1

0

High-throughput

0.426

High

491636

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

0

High-throughput

0.426

High

491685

RL24
Large ribosomal subunit protein uL24

1

0

High-throughput

0.426

High

491686

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.426

High

491687

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.426

High

491688

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.426

High

491674

HOFM
DNA utilization protein HofM

2

0

High-throughput

0.310

High

491692

SXY
Protein Sxy

2

0

High-throughput

0.310

High

366737

CYNS
Cyanate hydratase

1

0

High-throughput

0.279

Low

432385

MCP3
Methyl-accepting chemotaxis protein III

1

0

High-throughput

0.279

Low

491573

RECR
Recombination protein RecR

1

0

High-throughput

0.279

Low

491608

CLSB
Cardiolipin synthase B

1

0

High-throughput

0.279

Low

491613

CYOA
Cytochrome bo(3) ubiquinol oxidase subunit 2

1

0

High-throughput

0.279

Low

491620

YQIB
Uncharacterized protein YqiB

1

0

High-throughput

0.279

Low

491627

HYCH
Formate hydrogenlyase maturation protein HycH

1

0

High-throughput

0.279

Low

491631

RNK
Regulator of nucleoside diphosphate kinase

1

0

High-throughput

0.279

Low

491637

SIRB1
UPF0162 protein YchA

1

0

High-throughput

0.279

Low

491643

BIOC
Malonyl-[acyl-carrier protein] O-methyltransferase

1

0

High-throughput

0.279

Low

491645

MNGR
Mannosyl-D-glycerate transport/metabolism system repressor MngR

1

0

High-throughput

0.279

Low

491649

PHND
Phosphonates-binding periplasmic protein

1

0

High-throughput

0.279

Low

491650

BETI
HTH-type transcriptional regulator BetI

1

0

High-throughput

0.279

Low

491651

NARY
Respiratory nitrate reductase 2 beta chain

1

0

High-throughput

0.279

Low

491657

FLID
Flagellar hook-associated protein 2

1

0

High-throughput

0.279

Low

491658

ROXA
Ribosomal protein uL16 3-hydroxylase

1

0

High-throughput

0.279

Low

491659

MLTG
Endolytic murein transglycosylase

1

0

High-throughput

0.279

Low

491662

YIDL
Uncharacterized HTH-type transcriptional regulator YidL

1

0

High-throughput

0.279

Low

491675

END8
Endonuclease 8

1

0

High-throughput

0.279

Low

491676

HOA
4-hydroxy-2-oxovalerate aldolase

1

0

High-throughput

0.279

Low

491679

YFJR
Uncharacterized HTH-type transcriptional regulator YfjR

1

0

High-throughput

0.279

Low

491694

YDAT
Transcriptional regulator YdaT

1

0

High-throughput

0.279

Low

491695

YDCS
Bifunctional polyhydroxybutyrate synthase / ABC transporter periplasmic binding protein

1

0

High-throughput

0.279

Low

491696

YDIV
Putative anti-FlhC(2)FlhD(4) factor YdiV

1

0

High-throughput

0.279

Low

491697

NIMR
HTH-type transcriptional regulator NimR

1

0

High-throughput

0.279

Low

491698

YPJB
Protein YpjB

1

0

High-throughput

0.279

Low

491705

STFQ
Prophage side tail fiber protein homolog StfQ

1

0

High-throughput

0.279

Low

491706

YFHR
Uncharacterized protein YfhR

1

0

High-throughput

0.279

Low

491707

YDHW
Uncharacterized protein YdhW

1

0

High-throughput

0.279

Low

491711

YDJF
Uncharacterized HTH-type transcriptional regulator YdjF

1

0

High-throughput

0.279

Low

491713

YFES
Uncharacterized protein YfeS

1

0

High-throughput

0.279

Low

491714

LTND
L-threonate dehydrogenase

1

0

High-throughput

0.279

Low

491604

YBAQ
Uncharacterized HTH-type transcriptional regulator YbaQ

1

0

High-throughput

0.269

Low

491670

ERFK
Probable L,D-transpeptidase ErfK/SrfK

1

0

High-throughput

0.269

Low

491716

YAFN
Antitoxin YafN

1

0

High-throughput

0.269

Low

491634

CSDE
Sulfur acceptor protein CsdE

1

0

Small-scale

0.249

Low

491646

RECE
Exodeoxyribonuclease 8

1

0

High-throughput

0.249

Low

491619

YIBA
Protein YibA

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025