Protein: HEL2
E3 ubiquitin-protein ligase HEL2 (EC 2.3.2.27) (Histone E3 ligase 2) (RING-type E3 ubiquitin transferase HEL2)

Gene: HEL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 51
UniProt ID: Q05580

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0010629 - negative regulation of gene expression
GO:0016567 - protein ubiquitination
GO:0022626 - cytosolic ribosome
GO:0036205 - histone catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549835

UBC4
Ubiquitin-conjugating enzyme E2 4

5

3

Small-scale

0.927

High

407321

RS3
Small ribosomal subunit protein uS3

4

1

Small-scale

0.683

High

752669

RS20
Small ribosomal subunit protein uS10

3

1

Small-scale

0.667

High

861513

SLH1
RQC trigger complex helicase SLH1

2

2

Small-scale

0.601

High

742996

GBLP
Small ribosomal subunit protein RACK1

2

5

Small-scale

0.586

High

606142

RAD53
Serine/threonine-protein kinase RAD53

2

0

Small-scale

0.569

High

645652

RS7A
Small ribosomal subunit protein eS7A

2

1

Small-scale

0.543

High

977167

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.536

High

984238

HEL2
E3 ubiquitin-protein ligase HEL2

1

1

Small-scale

0.527

High

356725

H4
Histone H4

1

1

Small-scale

0.512

High

551391

ABP1
Actin-binding protein

1

1

High-throughput

0.501

High

688822

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.501

High

562761

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.480

High

615061

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

752212

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.480

High

485587

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.479

High

498596

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

605155

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

785215

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.479

High

482462

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

663321

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

733116

RQT4
RQC trigger complex subunit RQT4

1

0

Small-scale

0.458

High

756716

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

758097

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.458

High

767084

ARB1
ABC transporter ATP-binding protein ARB1

1

0

High-throughput

0.458

High

774151

TM108
Protein TMA108

1

0

High-throughput

0.458

High

859540

CUE3
RQC trigger complex subunit CUE3

1

0

Small-scale

0.458

High

984240

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

984242

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

984243

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

816542

RS7B
Small ribosomal subunit protein eS7B

1

1

Small-scale

0.457

High

366892

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

478527

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

492437

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

494959

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

512725

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

769470

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

866473

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

984241

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

773757

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

750727

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.279

Low

984239

YP114
Uncharacterized TLC domain-containing protein YPR114W

1

0

High-throughput

0.269

Low

772736

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

426153

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

480884

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

650389

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low

775862

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

902066

H3
Histone H3

1

0

Small-scale

0.249

Low

978284

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

866153

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024