Protein: PBPA
Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.99.28) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)]

Gene: PBPA, mrcA
Organism: Escherichia coli K-12
Interactions: 81
UniProt ID: P02918

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006508 - proteolysis
GO:0008360 - regulation of cell shape
GO:0008658 - penicillin binding
GO:0008955 - peptidoglycan glycosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

393879

MRDA
Peptidoglycan D,D-transpeptidase MrdA

2

16

Small-scale

0.786

High

393900

LPOA
Penicillin-binding protein activator LpoA

2

0

Small-scale

0.576

High

393838

PBPB
Penicillin-binding protein 1B

1

16

Small-scale

0.575

High

393872

FTSH
ATP-dependent zinc metalloprotease FtsH

1

0

High-throughput

0.513

High

393882

ELAB
Protein ElaB

1

2

High-throughput

0.479

High

393909

YQJD
Uncharacterized protein YqjD

1

2

High-throughput

0.479

High

366614

ASPG2
L-asparaginase 2

1

0

High-throughput

0.458

High

393860

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

393884

HDEB
Acid stress chaperone HdeB

1

0

High-throughput

0.458

High

393888

UGPB
sn-glycerol-3-phosphate-binding periplasmic protein UgpB

1

0

High-throughput

0.458

High

393889

PSTS
Phosphate-binding protein PstS

1

0

High-throughput

0.458

High

393892

EFTU1
Elongation factor Tu 1

1

0

High-throughput

0.458

High

393901

FKBA
FKBP-type peptidyl-prolyl cis-trans isomerase FkpA

1

0

High-throughput

0.458

High

393896

FTSN
Cell division protein FtsN

1

3

Small-scale

0.445

High

393839

PFLB
Formate acetyltransferase 1

1

1

High-throughput

0.437

High

393847

IHFA
Integration host factor subunit alpha

1

2

High-throughput

0.437

High

393863

TALB
Transaldolase B

1

1

High-throughput

0.437

High

393875

DBHA
DNA-binding protein HU-alpha

1

2

High-throughput

0.437

High

393895

SYD
Aspartate--tRNA ligase

1

1

High-throughput

0.437

High

393898

DHAM
PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM

1

1

High-throughput

0.437

High

393904

RL2
Large ribosomal subunit protein uL2

1

1

High-throughput

0.437

High

393908

CLPB
Chaperone protein ClpB

1

1

High-throughput

0.437

High

393910

GRCA
Autonomous glycyl radical cofactor

1

1

High-throughput

0.437

High

368816

SYA
Alanine--tRNA ligase

1

0

High-throughput

0.279

Low

393869

GATD
Galactitol 1-phosphate 5-dehydrogenase

1

0

High-throughput

0.279

Low

393877

YECA
Uncharacterized protein YecA

1

0

High-throughput

0.279

Low

393903

ABPB
Anti-bacteriophage protein B

1

0

High-throughput

0.279

Low

358850

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.249

Low

368507

MANA
Mannose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

383979

RL15
Large ribosomal subunit protein uL15

1

0

High-throughput

0.249

Low

393840

CH10
Co-chaperonin GroES

1

0

High-throughput

0.249

Low

393841

DEOB
Phosphopentomutase

1

0

High-throughput

0.249

Low

393842

EFG
Elongation factor G

1

0

High-throughput

0.249

Low

393843

EFP
Elongation factor P

1

0

High-throughput

0.249

Low

393844

EFTS
Elongation factor Ts

1

0

High-throughput

0.249

Low

393845

ENO
Enolase

1

0

High-throughput

0.249

Low

393846

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.249

Low

393848

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.249

Low

393849

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

393850

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

393851

RL19
Large ribosomal subunit protein bL19

1

0

High-throughput

0.249

Low

393852

RL1
Large ribosomal subunit protein uL1

1

0

High-throughput

0.249

Low

393853

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.249

Low

393854

RL9
Large ribosomal subunit protein bL9

1

0

High-throughput

0.249

Low

393855

RS10
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

393856

RS11
Small ribosomal subunit protein uS11

1

0

High-throughput

0.249

Low

393857

RS13
Small ribosomal subunit protein uS13

1

0

High-throughput

0.249

Low

393858

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.249

Low

393859

RS19
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

393861

GLYA
Serine hydroxymethyltransferase

1

0

High-throughput

0.249

Low

393862

TIG
Trigger factor

1

0

High-throughput

0.249

Low

393864

YBAB
Nucleoid-associated protein YbaB

1

0

High-throughput

0.249

Low

393865

NQOR
NAD(P)H dehydrogenase

1

0

High-throughput

0.249

Low

393866

SYK2
Lysine--tRNA ligase, heat inducible

1

0

High-throughput

0.249

Low

393867

FUR
Ferric uptake regulation protein

1

0

High-throughput

0.249

Low

393868

G3P1
Glyceraldehyde-3-phosphate dehydrogenase A

1

0

High-throughput

0.249

Low

393870

CSPC
Cold shock-like protein CspC

1

0

High-throughput

0.249

Low

393871

USPD
Universal stress protein D

1

0

High-throughput

0.249

Low

393873

YCCJ
Uncharacterized protein YccJ

1

0

High-throughput

0.249

Low

393874

DPS
DNA protection during starvation protein

1

0

High-throughput

0.249

Low

393876

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.249

Low

393878

YFCZ
UPF0381 protein YfcZ

1

0

High-throughput

0.249

Low

393880

RL16
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

393881

AHPC
Alkyl hydroperoxide reductase C

1

0

High-throughput

0.249

Low

393883

FABG
3-oxoacyl-[acyl-carrier-protein] reductase FabG

1

0

High-throughput

0.249

Low

393885

RISA
Riboflavin synthase

1

0

High-throughput

0.249

Low

393886

RS14
Small ribosomal subunit protein uS14

1

0

High-throughput

0.249

Low

393887

RS1
Small ribosomal subunit protein bS1

1

0

High-throughput

0.249

Low

393890

RL18
Large ribosomal subunit protein uL18

1

0

High-throughput

0.249

Low

393891

OSMC
Peroxiredoxin OsmC

1

0

High-throughput

0.249

Low

393893

KATG
Catalase-peroxidase

1

0

High-throughput

0.249

Low

393894

GLMS
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

393897

PGM
Phosphoglucomutase

1

0

High-throughput

0.249

Low

393899

RMLB1
dTDP-glucose 4,6-dehydratase 1

1

0

High-throughput

0.249

Low

393902

LUXS
S-ribosylhomocysteine lyase

1

0

High-throughput

0.249

Low

393905

RL24
Large ribosomal subunit protein uL24

1

0

High-throughput

0.249

Low

393906

MDH
Malate dehydrogenase

1

0

High-throughput

0.249

Low

393907

RL5
Large ribosomal subunit protein uL5

1

0

High-throughput

0.249

Low

393911

RL25
Large ribosomal subunit protein bL25

1

0

High-throughput

0.249

Low

393912

KAD
Adenylate kinase

1

0

High-throughput

0.249

Low

393913

DCEB
Glutamate decarboxylase beta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025