Protein: ERG1
Squalene epoxidase ERG1 (SE) (EC 1.14.14.17) (Ergosterol biosynthetic protein 1) (Squalene monooxygenase ERG1)

Gene: ERG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 71
UniProt ID: P32476

Gene Ontology (top 5):
GO:0004506 - squalene monooxygenase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005811 - lipid droplet
GO:0006696 - ergosterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690787

ERG25
C-4 methylsterol oxidase ERG25

2

1

Small-scale

0.632

High

629456

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

690377

ERG24
Delta(14)-sterol reductase ERG24

1

1

Small-scale

0.541

High

690778

ERG28
Ergosterol biosynthetic protein 28

1

0

Small-scale

0.529

High

690779

IMB4
Importin subunit beta-4

2

2

High-throughput

0.521

High

688566

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.518

High

690769

SC61G
Protein transport protein SSS1

1

0

High-throughput

0.518

High

690789

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

0

Small-scale

0.518

High

690792

ERG5
C-22 sterol desaturase ERG5

1

0

Small-scale

0.518

High

493455

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.504

High

510614

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.504

High

688588

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

High-throughput

0.479

High

690786

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.460

High

495810

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.458

High

690767

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.458

High

690770

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

690773

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

690797

RTN1
Reticulon-like protein 1

1

0

Small-scale

0.458

High

690802

GET3
ATPase GET3

1

0

Small-scale

0.458

High

690803

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

687905

IMB3
Importin subunit beta-3

1

3

High-throughput

0.437

High

690772

IMB2
Importin subunit beta-2

1

2

High-throughput

0.437

High

690798

IMB1
Importin subunit beta-1

1

2

High-throughput

0.437

High

490644

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.407

High

605722

NPR1
Nitrogen permease reactivator protein

1

1

High-throughput

0.407

High

690765

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

690780

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.407

High

543389

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.318

High

477181

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

0

Small-scale

0.310

High

690783

BUD27
Bud site selection protein 27

1

0

Small-scale

0.282

High

690788

MAL11
General alpha-glucoside permease

1

0

High-throughput

0.282

High

367852

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.279

Low

563939

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.279

Low

690774

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.279

Low

690781

SKP2
F-box protein SKP2

1

0

High-throughput

0.279

Low

383014

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

406884

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

413376

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

479985

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480548

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

599432

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.249

Low

602644

MCK1
Protein kinase MCK1

1

0

High-throughput

0.249

Low

604954

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.249

Low

606583

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

619430

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

619545

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.249

Low

627816

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

631739

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

661634

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

675886

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

680527

HS104
Heat shock protein 104

1

0

High-throughput

0.249

Low

688028

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.249

Low

690764

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

690766

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

690768

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

690771

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

690775

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

690776

FHP
Flavohemoprotein

1

0

High-throughput

0.249

Low

690777

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

High-throughput

0.249

Low

690782

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

690784

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.249

Low

690785

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

690790

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

690791

BRE5
UBP3-associated protein BRE5

1

0

Small-scale

0.249

Low

690793

UFD2
E4 ubiquitin-protein ligase UFD2

1

0

High-throughput

0.249

Low

690794

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.249

Low

690795

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.249

Low

690796

ESP1
Separin

1

0

High-throughput

0.249

Low

690799

SUB2
ATP-dependent RNA helicase SUB2

1

0

High-throughput

0.249

Low

690800

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

690801

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024